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anti-Human TERT Antibodies:
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Human Monoclonal TERT Primary Antibody for ICC, FACS - ABIN151783
Masutomi, Yu, Khurts, Ben-Porath, Currier, Metz, Brooks, Kaneko, Murakami, DeCaprio, Weinberg, Stewart, Hahn: Telomerase maintains telomere structure in normal human cells. in Cell 2003
Show all 15 Pubmed References
Human Monoclonal TERT Primary Antibody for FACS, ICC - ABIN151763
Zhang, Eguchi, Kruse, Gomez, Fakhrai, Schroter, Ma, Hoa, Minev, Delgado, Wepsic, Okada, Jadus: Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Show all 10 Pubmed References
Dog (Canine) Polyclonal TERT Primary Antibody for ICC, IF - ABIN265626
Walshe, Harkin: Serial explant culture provides novel insights into the potential location and phenotype of corneal endothelial progenitor cells. in Experimental eye research 2014
Show all 3 Pubmed References
Human Polyclonal TERT Primary Antibody for DB, IF - ABIN390002
Radan, Hughes, Teichroeb, Vieira Zamora, Jewer, Postovit, Betts: Microenvironmental regulation of telomerase isoforms in human embryonic stem cells. in Stem cells and development 2014
Show all 2 Pubmed References
Mouse (Murine) Polyclonal TERT Primary Antibody for WB - ABIN3043095
Qiu, Li, Sui, Sun, Huang, Si, Ge: Immunization with truncated sequence of Telomerase Reverse Transcriptase induces a specific antitumor response in vivo. in Acta oncologica (Stockholm, Sweden) 2007
Show all 2 Pubmed References
Human Polyclonal TERT Primary Antibody for IF (cc), IF (p) - ABIN686167
Gao, Zhao, Song, Yang: Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs. in Molecular biology reports 2012
Show all 2 Pubmed References
Human Polyclonal TERT Primary Antibody for FACS, IF - ABIN388165
Sekaric, Cherry, Androphy: Binding of human papillomavirus type 16 E6 to E6AP is not required for activation of hTERT. in Journal of virology 2007
Show all 3 Pubmed References
trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated
Telomerase-deficient zebrafish show p53 (show TP53 Antibodies)-dependent premature aging and reduced lifespan in the first generation.
These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.
Telomerase regulatory subunit Est3 in Candida species physically interacts with the TEN domain of TERT and telomeric DNA
Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.
The Japanese medaka is a new vertebrate model for studying tert biology.
significant association only between the TERT minisatellite MNS16A and Alzheimer's disease but only in males
E6 upregulation of hTERT by downregulated LKB1 (show STK11 Antibodies) and upregulated SP1 (show PSG1 Antibodies) in lung cancer cells. These results indicated that E6 played a predominant role in the regulation of telomerase activation and may be a valuable therapeutic targets for HPV-related cancer.
Age at diagnosis of follicular thyroid cancer (FTC (show FUT2 Antibodies)) and frequency of extrathyroidal extension have changed over four decades; prevalence of RAS mutations has decreased; HRAS/NRAS (codon 61) and TERT (promoter) mutations may be associated with poor clinical outcomes in FTC (show FUT2 Antibodies), especially when two mutations coexist; this retrospective study was conducted in Seoul.
TERT promoter mutations in predicting distant metastasis.
Variant in TERT gene is associated with lung cancer susceptibility.
TERT inhibition impairs cell cycle progression and enhances the pro-apoptotic effects of chemotherapeutic agents in TERT-positive cells.
Our results show that combined exogenous expression of hTERT and mutant CDK4 is an effective method to generate single-cell-derived Cancer-associated fibroblasts (CAFs) clones. This provides an innovative and suitable approach to investigate the heterogeneous function and phenotype of CAFs
Data suggest that NME2 participates in epigenetic repression of TERT expression via a mechanism that is dependent on interactions with G-quadruplex DNA; NME2 appears to interact with TERT promoter as NME2/REST/LSD1 (show KDM1A Antibodies) complex. (NME2 = metastasis suppressor protein 2; TERT = telomerase reverse transcriptase; REST = RE1-silencing transcription factor (show REST Antibodies); LSD1 (show KDM1A Antibodies) = lysine specific demethylase (show MBD2 Antibodies) 1)
the depleted beta-Arrestin1 (show ARRB1 Antibodies) reduced the interaction of P300 (show EP300 Antibodies) with Sp1 (show PSG1 Antibodies), thus to reduce Sp1 (show PSG1 Antibodies) binding to hTERT promoter, downregulate hTERT transcription, decrease telomerase activity, shorten telomere length, and promote Reh (show CES1 Antibodies) cell senescence.
We found that G allele of rs2736100 and G allele of rs2853669 in TERT gene, interaction between rs2736100 and smoking, and haplotype containing the rs2736100- G and rs2736109- A alleles were all associated with increased gastric cancer risk.
TERT has a role in neointima formation through epigenetic regulation of proliferative E2F1 (show E2F1 Antibodies) target gene expression in smooth muscle cells.
these findings support a model in which gain of TERT function modulates mTORC1 activity and induces autophagy.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (show MYC Antibodies), Cyc (show CYCS Antibodies)-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment
Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress
Wnt10a (show WNT10A Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.
This study reports the characterisation of two novel mouse TERT splice variants, Ins (show INS Antibodies)-i1[1-102] (Insi1 for short) and Del-e12 (show ELSPBP1 Antibodies)[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.
TERT may promote gastric cancer metastasis through the TERT-miR (show MLXIP Antibodies)-29a-ITGB1 (show ITGB1 Antibodies) regulatory pathway.
TERT switches macrophages towards M1 phenotype by regulating NF-kappaB (show NFKB1 Antibodies) signaling, but has limited effect on M2 macrophages polarization in vitro.
miR (show MLXIP Antibodies)-195 overexpressed in old mesenchymal stem cells (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR (show MLXIP Antibodies)-195 can reverse stem cell aging.
findings identified a key role for TERT in fibroblast proliferation and survival essential for pulmonary fibrosis
Telomere shortening is more rapid in fas (show FASN Antibodies) tert double mutants than in fas1 (show FAS Antibodies), fas2 or tert single mutant plants.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
study reports the physical interaction of an Arabidopsis POT1 (show POT1 Antibodies) protein, POT1A (show POT1 Antibodies) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (show DKC1 Antibodies) associates with active telomerase RNP (show RNPC3 Antibodies) particles in an RNA-dependent manner.
Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Telomerase Reverse Transcriptase family member (trt-1)
, telomerase reverse transcriptase
, hypothetical protein
, Telomerase catalytic subunit
, telomerase catalytic subunit
, telomerase-associated protein 2
, telomerase reverse transcriptase beta