TERT antibody (pTyr707)

Catalog No. ABIN390002

There are 2+ publications for this product available. The Rabbit Polyclonal anti-TERT antibody is suitable to detect TERT in samples from Human. It has been validated for IF and DB.

Quick Overview for TERT antibody (pTyr707) (ABIN390002)

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TERT antibody is un-conjugated

Application: Immunofluorescence (IF), Dot Blot (DB)

Clone: RB16840

Product Details anti-TERT Antibody

Binding Specificity: pTyr707

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TERT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y707 of human TERT.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-TERT antibody (ABIN390002)

Radan, Hughes, Teichroeb, Vieira Zamora, Jewer, Postovit, Betts: "Microenvironmental regulation of telomerase isoforms in human embryonic stem cells." in: Stem cells and development, Vol. 23, Issue 17, pp. 2046-66, (2014) (PubMed).

Pecec, Voiculetz: "An antibody sandwich method for the radioimmunoassay of human alpha-fetoprotein." in: Immunochemistry, Vol. 11, Issue 12, pp. 771-5, (1975) (PubMed).

Target Details for TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Alternative Name: TERT

Background: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

Molecular Weight: 126997

Gene ID: 7015

NCBI Accession: NP_001180305, NP_937983

UniProt: O14746

Pathways: Telomere Maintenance