TERT antibody (pTyr707)

Catalog No. ABIN3029107

This Rabbit Polyclonal antibody specifically detects TERT in ELISA, IF and DB. It exhibits reactivity toward Human.

Quick Overview for TERT antibody (pTyr707) (ABIN3029107)

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TERT antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Dot Blot (DB)

Product Details anti-TERT Antibody

Binding Specificity: pTyr707

Purpose: Phospho-TERT Antibody (pY707)

Purification: Antigen affinity

Immunogen: This phospho-TERT antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY707 of human TERT.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the phospho-TERT antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the phospho-TERT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Alternative Name: TERT

Background: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

UniProt: O14746

Pathways: Telomere Maintenance