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Browse our GRP78 Proteins (HSPA5)

Full name:
Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) Proteins (HSPA5)
On www.antibodies-online.com are 25 Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) Proteins from 9 different suppliers available. Additionally we are shipping GRP78 Antibodies (466) and GRP78 Kits (41) and many more products for this protein. A total of 541 GRP78 products are currently listed.
Synonyms:
AL022860, AU019543, baffled, Bip, cb865, D2Wsu17e, D2Wsu141e, fb60h09, fi36d04, GRP-78, Grp78, Hsce70, hspa5a, mBiP, MIF2, SEZ-7, Sez7, wu:fb60h09, wu:fi36d04, zgc:55994, zgc:77606
list all proteins Gene Name GeneID UniProt
HSPA5 3309 P11021
HSPA5 14828 P20029
HSPA5 25617 P06761

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GRP78 Proteins (HSPA5) by Origin

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Top referenced GRP78 Proteins

  1. Human GRP78 Protein expressed in Escherichia coli (E. coli) - ABIN1686700 : Yang, Turner, Gaut: The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion. in The Journal of biological chemistry 1998 (PubMed)
    Show all 10 references for ABIN1686700

  2. Human GRP78 Protein expressed in Escherichia coli (E. coli) - ABIN1686682 : Rechthand, Smith, Latker, Rapoport: Altered blood-nerve barrier permeability to small molecules in experimental diabetes mellitus. in Journal of neuropathology and experimental neurology 1987 (PubMed)
    Show all 9 references for ABIN1686682

  3. Human GRP78 Protein expressed in Wheat germ - ABIN1307202 : Taylor, Gercel-Taylor, Parker: Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer. in Gynecologic oncology 2009 (PubMed)

More Proteins for GRP78 Interaction Partners

Xenopus laevis Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. In amphibians, the association of BiP with unfolded protein and its possible role in aggresome function may be vital in the maintenance of cellular proteostasis.

  2. Hspa5 is essential for pronephros formation by mediating retinoic acid signaling.

Human Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. this study discovered a novel effect of free fatty acids or high-concentration glucose on hepatitis A virus replication in association with a reduction in the expression of glucose-regulated protein 78 (GRP78).

  2. Increased GRP78 expression in complex atypical endometrial hyperplasia was associated with occult endometrial carcinoma.

  3. Our results suggest that physical exercise alleviates endoplasmic reticulum stress in human obese through attenuation of GRP78 signaling network

  4. BiP (show GDF10 Proteins) expression is modulated upon Francisella infection and is required to support its intracellular multiplication.

  5. Forced expression of GRP78 in tumor cells promoted autophagy. GRP78 knockdown suppressed tumor cell autophagy.

  6. GRP78 overexpression abolished the inhibitory effect of SCNN1B (show SCNN1B Proteins) on cell growth and migration, whereas GRP78 silencing aggravated growth inhibition by SCNN1B (show SCNN1B Proteins) in gastric cancer.

  7. Genetic or pharmacologic inhibition of the HSPA5-GPX4 (show GPX4 Proteins) pathway enhanced gemcitabine sensitivity by disinhibiting ferroptosis in vitro and in both subcutaneous and orthotopic animal models of PDAC.

  8. Conclusively, GRP78 plays a vital role in gemcitabine resistance and clinical strategy to improve gemcitabine efficacy in breast cancer by manipulating GRP78 should be explored.

  9. GRP78 mainly demonstrates anti-hepatitis B virus effects, reducing hepatitis B virus production and HBeAg secretion.

  10. The increased BiP/GRP78 expression was clarified as an independent prognostic marker for predicting worse outcome.

Cow (Bovine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. This paper reports the localization of both GRP78 and HSP60 (show HSPD1 Proteins) on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 (show HSPD1 Proteins) in the sperm midpiece.

  2. BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death

Pig (Porcine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Over-expression of GRP78 enhances replication of Porcine Circovirus 2.

Mouse (Murine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. These results indicate that GRP78, an endoplasmic reticulum chaperon of the HSP70 (show HSP70 Proteins) family, is a novel host factor involved at multiple steps of the Japanese encephalitis virus life cycle and could be a potential therapeutic target.

  2. Genetic or pharmacologic inhibition of the HSPA5-GPX4 (show GPX4 Proteins) pathway enhanced gemcitabine sensitivity by disinhibiting ferroptosis in vitro and in both subcutaneous and orthotopic animal models of PDAC.

  3. The data presented indicate that the unfolded protein response is activated in fibrotic lung tissue and strongly localized to macrophages. GRP78- and CHOP (show DDIT3 Proteins)-mediated macrophage apoptosis was found to protect against bleomycin-induced fibrosis.

  4. Endoplasmic reticulum stress gene GRP78 is involved in signaling pathway during hepatitis B virus-mediated hepatocarcinogenesis.

  5. data show that Med inhibits ER stress-induced apoptosis and promotes osteoblast cell survival by targeting GRP78.

  6. These results suggested the important roles of endoplasmic reticulum-related chaperons, Bip and SIL1 (show SIL1 Proteins), in Alzheimer's disease-like tau hyperphosphorylation.

  7. We show that chronic VPA treatment did not modify the ATXN3 (show ATXN3 Proteins) inclusion load and astrogliosis in affected brain regions However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects

  8. these findings reveal a novel critical role of GRP78 in regulating ER stress-mediated apoptosis in cartilage development and the molecular mechanisms involved.

  9. ISM is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src (show SRC Proteins) activation as well as induction of apoptosis

  10. BIP increased surface CD19 molecule (show CD19 Proteins) expression intensity and IL-10 (show IL10 Proteins)(+), PD-L1 (show CD274 Proteins)(hi) and FasL (show FASL Proteins)(hi) B cells induced by BIP share the CD19 (show CD19 Proteins)(hi) phenotype

Zebrafish Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.

GRP78 (HSPA5) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.

Alternative names and synonyms associated with GRP78 (HSPA5)

  • 78 kDa glucose-regulated protein (CpipJ_CPIJ003550)
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HSPA5)
  • 78 kDa glucose-regulated protein (grp78)
  • BiP/GRP78 (LOC100533358)
  • glucose-regulated protein 78 (BiP/grp78)
  • glucose-regulated protein 78 (Tc00.1047053506585.40)
  • glucose-regulated protein 78 (Tb11.02.5450)
  • glucose-regulated protein 78 (Tb11.02.5500)
  • glucose-regulated protein 78 (LmjF28.1200)
  • Hsp70 family ATPase KAR2 (KAR2)
  • glucose-regulated protein 78kDa (grp78)
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (hspa5)
  • heat shock 70 kDa protein 5a (hspa5)
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (Hspa5)
  • heat shock protein 5 (Hspa5)
  • heat shock protein 5 (hspa5)
  • AL022860 protein
  • AU019543 protein
  • baffled protein
  • Bip protein
  • cb865 protein
  • D2Wsu17e protein
  • D2Wsu141e protein
  • fb60h09 protein
  • fi36d04 protein
  • GRP-78 protein
  • Grp78 protein
  • Hsce70 protein
  • hspa5a protein
  • mBiP protein
  • MIF2 protein
  • SEZ-7 protein
  • Sez7 protein
  • wu:fb60h09 protein
  • wu:fi36d04 protein
  • zgc:55994 protein
  • zgc:77606 protein

Protein level used designations for HSPA5

78 kDa glucose-regulated protein , GRP-78 , heat shock 70 kDa protein 5 , Protein 1603 , 78 kDa glucose-regulated protein homolog , luminal-binding protein , glucose-regulated protein 78 , glucose-regulated protein 78kDa , heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) , GRP 78 , biP , heavy-chain binding protein BiP , immunoglobulin heavy chain-binding protein , endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 , glucose-regulated protein, 78kDa , XAP-1 antigen , glucose regulated protein, 78 kDa , heat shock 70kD protein 5 (glucose-regulated protein, 78kD) , heat shock 70kD protein 5 , heat shock 70kDa protein 5 (glucose-regulated protein) , steroidogenesis-activator polypeptide , bip

GENE ID SPECIES
6034961 Culex quinquefasciatus
100173944 Pongo abelii
100196613 Salmo salar
100533358 Aplysia californica
543957 Solanum lycopersicum
3540481 Trypanosoma cruzi strain CL Brener
3665880 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3665885 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5653331 Leishmania major strain Friedlin
853418 Saccharomyces cerevisiae S288c
100135840 Oncorhynchus mykiss
379756 Xenopus laevis
464733 Pan troglodytes
703193 Macaca mulatta
100015941 Monodelphis domestica
100599238 Nomascus leucogenys
397850 Xenopus laevis
3309 Homo sapiens
415113 Bos taurus
396487 Gallus gallus
100731108 Cavia porcellus
407060 Sus scrofa
480726 Canis lupus familiaris
780447 Ovis aries
14828 Mus musculus
25617 Rattus norvegicus
378848 Danio rerio
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