GRP78 Protein (AA 20-650) (His tag)

Catalog No. ABIN667728

Product Details

Target: GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))

Protein Type: Recombinant

Protein Characteristics: AA 20-650

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This GRP78 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: BIP, 20-650aa, Human, His-Tagged, Recombinant, E.coli

Purity: > 90 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid in 20mM Tris pH 8.0, 10% glycerol

Storage: 4 °C

Target Details

Target: GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))

Alternative Name: BIP (HSPA5 Products)

Synonyms: GRP78 Protein, BiP Protein, GRP-78 Protein, grp78 Protein, hspa5a Protein, BIP Protein, MIF2 Protein, AL022860 Protein, AU019543 Protein, Bip Protein, D2Wsu141e Protein, D2Wsu17e Protein, Grp78 Protein, Hsce70 Protein, SEZ-7 Protein, Sez7 Protein, baffled Protein, mBiP Protein, cb865 Protein, fb60h09 Protein, fi36d04 Protein, wu:fb60h09 Protein, wu:fi36d04 Protein, zgc:55994 Protein, zgc:77606 Protein, 78 kDa glucose-regulated protein Protein, heat shock protein family A (Hsp70) member 5 Protein, BiP/GRP78 Protein, glucose-regulated protein 78 Protein, putative glucose-regulated protein 78 Protein, Hsp70 family ATPase KAR2 Protein, heat shock protein family A (Hsp70) member 5 S homeolog Protein, heat shock 70 kDa protein 5a Protein, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Protein, heat shock protein 5 Protein, heat shock protein family A member 5 Protein, CpipJ_CPIJ003550 Protein, HSPA5 Protein, grp78 Protein, LOC100533358 Protein, BiP/grp78 Protein, Tc00.1047053506585.40 Protein, Tb11.02.5450 Protein, Tb11.02.5500 Protein, LMJF_28_1200 Protein, KAR2 Protein, LOC100135840 Protein, hspa5.S Protein, hspa5 Protein, Hspa5 Protein

Background: Binding immunoglobulin protein (BiP) belongs to the family of ~70 kDa heat shock proteins (HSP 70). It is a stress response protein which is induced by agents or conditions that adversely affect endoplasmic reticulum (ER) function. This protein is essential for the proper glycosylation, folding as well as for the maintenance of cell homeostasis and the prevention of apoptosis. Recombinant human BIP protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: HSPA5, heat shock 70kDa protein 5, GRP78, glucose-regulated protein 78kD, MIF2, Binding immunoglobulin protein, BIP, Binding immunoglobulin protein 78 kDa glucose regulated protein, Endoplasmic reticulum lumenal Ca2+ binding protein grp78, FLJ26106, Glucose Regulated Protein 78kDa, GRP 78, GRP78, Heat Shock 70kDa Protein 5, HSPA 5, Immunoglobulin Heavy Chain Binding Protein. NCBI no.: NP_005338.1

Molecular Weight: 71 kDa (640 aa)

Pathways: Thyroid Hormone Synthesis, ER-Nucleus Signaling