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Browse our PAX8 Proteins (PAX8)

Full name:
Paired Box 8 Proteins (PAX8)
On www.antibodies-online.com are 15 Paired Box 8 (PAX8) Proteins from 6 different suppliers available. Additionally we are shipping PAX8 Antibodies (199) and PAX8 Kits (4) and many more products for this protein. A total of 231 PAX8 products are currently listed.
Synonyms:
Pax-8, PAX8, XPax-8, XPax8
list all proteins Gene Name GeneID UniProt
PAX8 7849 Q06710
PAX8 81819 P51974
PAX8 18510 Q00288

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PAX8 Proteins (PAX8) by Origin

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Top referenced PAX8 Proteins

  1. Human PAX8 Protein expressed in Escherichia coli (E. coli) - ABIN2006212 : Poleev, Wendler, Fickenscher, Zannini, Yaginuma, Abbott, Plachov: Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors. in European journal of biochemistry / FEBS 1995 (PubMed)

More Proteins for PAX8 Interaction Partners

Human Paired Box 8 (PAX8) interaction partners

  1. we replicated one known signal in PAX8 (2.6 minutes per allele, 95% CI [1.9, 3.2], P = 5.7x10-16) and identified and replicated two novel associations at VRK2 (show VRK2 Proteins) (2.0 minutes per allele, 95% CI [1.3, 2.7], P = 1.2x10-9; and 1.6 minutes per allele, 95% CI [1.1, 2.2], P = 7.6x10-9)

  2. Putative PAX8 target genes are enriched for common serous epithelial ovarian cancer risk variants.

  3. We conclude that PAX8 immunostain is negative in most cervical cell carcinomas and is less frequently expressed in endocervical adenocarcinomas as compared with the previously reported high sensitivity for ovarian and endometrial adenocarcinomas

  4. Study postulated that both TTF-1 (show NKX2-1 Proteins) and PAX-8 when co-expressed and have anti-proliferative and anti-tumorigenic properties up to a threshold expression level and beyond that, are able to induce pro-tumorigenic effects in thyroid carcinomas.

  5. Direct sequencing of the PAX8 gene revealed a novel single nucleotide substitution (c.162 A>T) in exon 2 that resulted in the substitution of the normal serine 54 with a cysteine (S54C), which segregated with elevated serum TSH levels.

  6. This is the first report of PAX8 aberrant transcript production in cervical cancer. Reported PAX8 isoforms possess differential transactivation properties; therefore, besides being a helpful marker for detection of cancer, PAX8 isoforms can plausibly exert differential regulation properties during carcinogenesis

  7. PAX2 (show PAX2 Proteins), PAX8, CDX2 (show CDX2 Proteins) immunostains was preformed to the TMA slides.

  8. Pax8 gene Rearrangement is associated with Breast Cancer.

  9. PAX8 was negative in all cases of pulmonary neuroendocrine carcinoma (PNEC) while positive in 86.4% of thymic cases (TNEC). TTF-1 (show NKX2-1 Proteins) positivity was associated with high sensitivity but low specificity for PNEC, and adding PAX8 negativity significantly increased the specificity. PAX8 positivity alone showed essentially 100% specificity and 86.4% sensitivity for TNEC.

  10. Study suggested that PAX8 eQTLs SNPs (rs4848320 and rs1110839) located in lncRNA PAX8-AS1 might predict decreased risk of cervical cancer.

Xenopus laevis Paired Box 8 (PAX8) interaction partners

  1. Pax8 is required for cell proliferation of pronephric precursors and regulates the expression of hnf1b (show HNF1B Proteins) and wnt (show WNT2 Proteins) pathway genes in the kidney field.

  2. nephrogenic transcription factors (osr1 (show OSR1 Proteins), osr2, hnf1b (show HNF1B Proteins), lhx1 (show LHX1 Proteins), pax8)play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (show INHBA Proteins), retinoic acid

Mouse (Murine) Paired Box 8 (PAX8) interaction partners

  1. These results suggest that Pax8 maybe the downstream molecule of ALK3 (show BMPR1A Proteins), it mediates the murine heart development via cellular senescence, which may serve as a mechanism that compensates for the cell loss via apoptosis in heart development.

  2. Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure

  3. PAX8 protein expression was associated with germinal layers in human and murine forebrain and hindbrain development.

  4. Pax8 is essential for function and survival of adult thyroid cells.

  5. a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.

  6. The Pax8 promoter appears to be autoregulated, a feature that might be responsible for the haploinsufficiency displayed by this gene.

  7. Inducible, Pax8-rtTA-based deletion of VHL (show VHL Proteins) leads to organ-specific expression of epithelial HIF and erythropoietin (show EPO Proteins) in liver and kidney without causing pathological changes.

  8. study concludes that Cadherin-16 is a novel downstream target of the transcription factor Pax8, likely since the early steps of thyroid development, and that its expression is associated with the fully differentiated state of the thyroid cell

  9. a thyroid-specific regulatory element in the 5' upstream region of the Pax8 gene

  10. these data identify Pax2 (show PAX2 Proteins) and Pax8 as critical regulators that specify the nephric lineage.

Zebrafish Paired Box 8 (PAX8) interaction partners

  1. Pax2a and Pax8 regulate cell differentiation during sensory placode formation

  2. pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1 (show FOXI1 Proteins), a necessary step for further otic development

  3. evolutionary links between jaw and ear formation can be traced to Fgf-Foxi1 (show FOXI1 Proteins)-Pax8 pathways

  4. Pax2a and Pax8 are the main effectors downstream of Fgf signals in ear formation

  5. pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate

PAX8 Protein Profile

Protein Summary

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternative names and synonyms associated with PAX8

  • paired box 8 (PAX8)
  • paired box 8 (pax8)
  • paired box 8 (Pax8)
  • paired box gene 8 (Pax8)
  • paired box gene 8 (pax8)
  • Pax-8 protein
  • PAX8 protein
  • XPax-8 protein
  • XPax8 protein

Protein level used designations for Paired Box 8 Proteins (PAX8)

paired box 8 , paired box gene 8 , paired box protein Pax-8 , paired domain gene 8 , Pax-8 protein , Pax-8 DNA-binding transcription factor , XPax-8

GENE ID SPECIES
701906 Macaca mulatta
780226 Xenopus (Silurana) tropicalis
100189903 Pongo abelii
7849 Homo sapiens
81819 Rattus norvegicus
403927 Canis lupus familiaris
534661 Bos taurus
398132 Xenopus laevis
18510 Mus musculus
60637 Danio rerio
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