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Human LY96 Protein expressed in HEK-293 Cells - ABIN2725664
Dulay, Buhimschi, Zhao, Oliver, Abdel-Razeq, Shook, Bahtiyar, Buhimschi: Amniotic Fluid Soluble Myeloid Differentiation-2 (sMD-2) as Regulator of Intra-amniotic Inflammation in Infection-induced Preterm Birth. in American journal of reproductive immunology (New York, N.Y. : 1989) 2015
The observations suggest that MD-2 helps to regulate lipopolysaccharide-induced NLRP3 (show NLRP3 Proteins) inflammasome activation and the inflammatory response in NR8383 cells, and likely does so by affecting MyD88 (show MYD88 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling.
MD2 plays an important role in induction of allergic sensitization to cat dander and common pollens relevant to human allergic diseases.
we report that exogenous CnB (show PPP3R1 Proteins) is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4 (show TLR4 Proteins)/MD2 complex together with the co-receptor CD14 (show NDUFA2 Proteins)
In this study, a novel naturally occurring spliceosome of human MD2, termed as MD2-T3, has been identified.
Results show that cigarette smoke may alter innate immune responses reducing the expression of the MD2, a molecule with an important role in TLR4 (show TLR4 Proteins) signaling.
Predominantly hydrophobic interactions between MD-2 and TLR4 (show TLR4 Proteins) contribute to the stabilization of the TLR4 (show TLR4 Proteins)/MD-2/metal ion complex in a conformation that enables activation.
The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 (show TLR4 Proteins) ligands may be facilitated through synthesis and release of sMD2 (show SNRPD2 Proteins) by the amniochorion.
Three genes (LY96, IL8 (show IL8 Proteins) DPR (show DACT1 Proteins)) were significantly downregulated over time. This finding was confirmed in a validation cohort of stroke patients (n=8).
The study revealed the impact of specific residues and regions of MD-2 on the binding of lipolysaccharides and TLR4 (show TLR4 Proteins).
Gene polymorphisms of MD2 and GM2A (show GM2A Proteins) were associated with the occurrence or severity of neonatal necrotizing enterocolitis.
This study provides evidence that MD2 plays a key role in the pathogenesis of retinal I/R damage.
Data suggest that C4bp prevents interaction between Tlr4 (show TLR4 Proteins)/MD-2 and its ligand; C4bp does not appear to interact with Tlr3 (show TLR3 Proteins); C4bp binds to macrophage surface Tlr4 (show TLR4 Proteins) and inhibits Tlr/Tlr ligand interaction, thereby inhibiting Tlr4 (show TLR4 Proteins) activation. (C4bp = complement component 4 binding protein; Tlr = toll (show TLR4 Proteins)-like receptor; MD-2 = myeloid differentiation protein-2)
Oxidative stress in retinal ischemia-reperfusion injury activates TLR4 (show TLR4 Proteins) signaling via MD2.
Neoseptin-3 and lipid A form dissimilar molecular contacts to achieve receptor activation; hence strong TLR4 (show TLR4 Proteins)/MD-2 agonists need not mimic LPS (show TLR4 Proteins)
Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 (show TLR4 Proteins) ancillary molecule.
MD-2 is a critical regulator of the establishment of allergic airway sensitization to HDM (show HDAC3 Proteins) in mice. Serum MD-2 may represent a potential biomarker for the amplification of allergic sensitization and allergic inflammation.
Data show that myeloid differentiation factor 2 (MD-2) binds specifically to disulfide isoform of box protein 1, high mobility group (show SSRP1 Proteins) (HMGB1 (show HMGB1 Proteins)) to facilitate toll-like receptor 4 (TLR4 (show TLR4 Proteins))-dependent signaling.
Carbon monoxide treatment reduces the expression of the TLR4 (show TLR4 Proteins)/MD2 complex on the surface of myeloid cells, which renders them resistant to lipopolysaccharide priming in vitro, as well as in vivo in a model of endotoxic shock.
Mechanistically, engagement of MD-2 by PTX3 (show PITX3 Proteins)-opsonized Aspergillus conidia activated the TLR4/Toll (show TLR4 Proteins)/IL-1R domain-containing adapter inducing IFN-beta (show IFNB1 Proteins)-dependent signaling pathway converging on IL-10 (show IL10 Proteins).
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms.
myeloid differentiation protein-2
, protein MD-2
, myeloid differentiation factor-2
, LPS co-receptor MD-2
, lymphocyte antigen 96
, Protein MD-2