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In this study, a novel naturally occurring spliceosome of human MD2, termed as MD2-T3, has been identified.
Results show that cigarette smoke may alter innate immune responses reducing the expression of the MD2, a molecule with an important role in TLR4 (show TLR4 Proteins) signaling.
Predominantly hydrophobic interactions between MD-2 and TLR4 (show TLR4 Proteins) contribute to the stabilization of the TLR4 (show TLR4 Proteins)/MD-2/metal ion complex in a conformation that enables activation.
The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 (show TLR4 Proteins) ligands may be facilitated through synthesis and release of sMD2 (show SNRPD2 Proteins) by the amniochorion.
Three genes (LY96, IL8 (show IL8 Proteins) DPR (show DACT1 Proteins)) were significantly downregulated over time. This finding was confirmed in a validation cohort of stroke patients (n=8).
The study revealed the impact of specific residues and regions of MD-2 on the binding of lipolysaccharides and TLR4 (show TLR4 Proteins).
Gene polymorphisms of MD2 and GM2A (show GM2A Proteins) were associated with the occurrence or severity of neonatal necrotizing enterocolitis.
In patients undergoing CABG surgery, we found genetic polymorphisms in LY96 associated with decreased risk of postoperative AF.
Aminoarabinose residues in lipid A contribute to Burkholderia lipid A binding to the TLR4 (show TLR4 Proteins).Myeloid Differentiation Factor 2 complex.
TLR4 (show TLR4 Proteins) along with its accessory protein MD-2 builds a heterodimeric complex that specifically recognizes lipopolysaccharides, which are present on the cell wall of gram-negative bacteria, activating the immune response. (Review)
Neoseptin-3 and lipid A form dissimilar molecular contacts to achieve receptor activation; hence strong TLR4 (show TLR4 Proteins)/MD-2 agonists need not mimic LPS (show TLR4 Proteins)
Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 (show TLR4 Proteins) ancillary molecule.
MD-2 is a critical regulator of the establishment of allergic airway sensitization to HDM (show HDAC3 Proteins) in mice. Serum MD-2 may represent a potential biomarker for the amplification of allergic sensitization and allergic inflammation.
Data show that myeloid differentiation factor 2 (MD-2) binds specifically to disulfide isoform of box protein 1, high mobility group (show SSRP1 Proteins) (HMGB1 (show HMGB1 Proteins)) to facilitate toll-like receptor 4 (TLR4 (show TLR4 Proteins))-dependent signaling.
Carbon monoxide treatment reduces the expression of the TLR4 (show TLR4 Proteins)/MD2 complex on the surface of myeloid cells, which renders them resistant to lipopolysaccharide priming in vitro, as well as in vivo in a model of endotoxic shock.
Mechanistically, engagement of MD-2 by PTX3 (show PITX3 Proteins)-opsonized Aspergillus conidia activated the TLR4/Toll (show TLR4 Proteins)/IL-1R domain-containing adapter inducing IFN-beta (show IFNB1 Proteins)-dependent signaling pathway converging on IL-10 (show IL10 Proteins).
SAA3 (show SAA3 Proteins) directly binds MD-2 and activates the MyD88 (show MYD88 Proteins)-dependent TLR4 (show TLR4 Proteins)/MD-2 pathway.
Monophosphoryl lipid A is unable to efficiently form TLR4 (show TLR4 Proteins)/MD-2 heterotetramers, but it still needs heterotetramer formation for the full extent of signaling it is able to achieve.
Data show that rifampin binds to myeloid differentiation protein 2 (MD-2), the key coreceptor for innate immune TLR4 (show TLR4 Proteins).
Gb4 is an endogenous ligand for TLR4 (show TLR4 Proteins)-MD-2 and is capable of attenuating LPS (show TLR4 Proteins) toxicity, indicating the possibility for its therapeutic application in endotoxin shock.
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms.
myeloid differentiation protein-2
, protein MD-2
, myeloid differentiation factor-2
, LPS co-receptor MD-2
, lymphocyte antigen 96
, Protein MD-2