Browse our LY96 Proteins (LY96)

Full name:
Lymphocyte Antigen 96 Proteins (LY96)
On are 13 Lymphocyte Antigen 96 (LY96) Proteins from 8 different suppliers available. Additionally we are shipping LY96 Antibodies (105) and LY96 Kits (18) and many more products for this protein. A total of 144 LY96 products are currently listed.
ESOP-1, Ly-96, MD-2, Md2
list all proteins Gene Name GeneID UniProt
LY96 23643 Q9Y6Y9
LY96 17087 Q9JHF9
Rat LY96 LY96 448830  

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LY96 Proteins (LY96) by Origin

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Top referenced LY96 Proteins

  1. Human LY96 Protein expressed in HEK-293 Cells - ABIN2725664 : Dulay, Buhimschi, Zhao, Oliver, Abdel-Razeq, Shook, Bahtiyar, Buhimschi: Amniotic Fluid Soluble Myeloid Differentiation-2 (sMD-2) as Regulator of Intra-amniotic Inflammation in Infection-induced Preterm Birth. in American journal of reproductive immunology (New York, N.Y. : 1989) 2015 (PubMed)

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Human Lymphocyte Antigen 96 (LY96) interaction partners

  1. MD2 plays an important role in induction of allergic sensitization to cat dander and common pollens relevant to human allergic diseases.

  2. we report that exogenous CnB (show PPP3R1 Proteins) is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4 (show TLR4 Proteins)/MD2 complex together with the co-receptor CD14 (show NDUFA2 Proteins)

  3. In this study, a novel naturally occurring spliceosome of human MD2, termed as MD2-T3, has been identified.

  4. Results show that cigarette smoke may alter innate immune responses reducing the expression of the MD2, a molecule with an important role in TLR4 (show TLR4 Proteins) signaling.

  5. Predominantly hydrophobic interactions between MD-2 and TLR4 (show TLR4 Proteins) contribute to the stabilization of the TLR4 (show TLR4 Proteins)/MD-2/metal ion complex in a conformation that enables activation.

  6. The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 (show TLR4 Proteins) ligands may be facilitated through synthesis and release of sMD2 (show SNRPD2 Proteins) by the amniochorion.

  7. Three genes (LY96, IL8 (show IL8 Proteins) DPR (show DACT1 Proteins)) were significantly downregulated over time. This finding was confirmed in a validation cohort of stroke patients (n=8).

  8. The study revealed the impact of specific residues and regions of MD-2 on the binding of lipolysaccharides and TLR4 (show TLR4 Proteins).

  9. Gene polymorphisms of MD2 and GM2A (show GM2A Proteins) were associated with the occurrence or severity of neonatal necrotizing enterocolitis.

  10. In patients undergoing CABG surgery, we found genetic polymorphisms in LY96 associated with decreased risk of postoperative AF.

Mouse (Murine) Lymphocyte Antigen 96 (LY96) interaction partners

  1. MD2 plays an important role in induction of allergic sensitization to cat dander and common pollens relevant to human allergic diseases.

  2. Oxidative stress in retinal ischemia-reperfusion injury activates TLR4 (show TLR4 Proteins) signaling via MD2.

  3. Neoseptin-3 and lipid A form dissimilar molecular contacts to achieve receptor activation; hence strong TLR4 (show TLR4 Proteins)/MD-2 agonists need not mimic LPS (show TLR4 Proteins)

  4. Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 (show TLR4 Proteins) ancillary molecule.

  5. MD-2 is a critical regulator of the establishment of allergic airway sensitization to HDM (show HDAC3 Proteins) in mice. Serum MD-2 may represent a potential biomarker for the amplification of allergic sensitization and allergic inflammation.

  6. Data show that myeloid differentiation factor 2 (MD-2) binds specifically to disulfide isoform of box protein 1, high mobility group (show SSRP1 Proteins) (HMGB1 (show HMGB1 Proteins)) to facilitate toll-like receptor 4 (TLR4 (show TLR4 Proteins))-dependent signaling.

  7. Carbon monoxide treatment reduces the expression of the TLR4 (show TLR4 Proteins)/MD2 complex on the surface of myeloid cells, which renders them resistant to lipopolysaccharide priming in vitro, as well as in vivo in a model of endotoxic shock.

  8. Mechanistically, engagement of MD-2 by PTX3 (show PITX3 Proteins)-opsonized Aspergillus conidia activated the TLR4/Toll (show TLR4 Proteins)/IL-1R domain-containing adapter inducing IFN-beta (show IFNB1 Proteins)-dependent signaling pathway converging on IL-10 (show IL10 Proteins).

  9. SAA3 (show SAA3 Proteins) directly binds MD-2 and activates the MyD88 (show MYD88 Proteins)-dependent TLR4 (show TLR4 Proteins)/MD-2 pathway.

  10. Monophosphoryl lipid A is unable to efficiently form TLR4 (show TLR4 Proteins)/MD-2 heterotetramers, but it still needs heterotetramer formation for the full extent of signaling it is able to achieve.

LY96 Protein Profile

Protein Summary

This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with LY96

  • lymphocyte antigen 96 (LY96)
  • lymphocyte antigen 96 (Ly96)
  • ESOP-1 protein
  • Ly-96 protein
  • MD-2 protein
  • Md2 protein

Protein level used designations for Lymphocyte Antigen 96 Proteins (LY96)

myeloid differentiation protein-2 , protein MD-2 , ly-96 , myeloid differentiation factor-2 , LPS co-receptor MD-2 , lymphocyte antigen 96 , MD-2 , Protein MD-2

696778 Macaca mulatta
23643 Homo sapiens
17087 Mus musculus
448830 Rattus norvegicus
613753 Bos taurus
610524 Canis lupus familiaris
420189 Gallus gallus
100729146 Cavia porcellus
100125555 Sus scrofa
100009589 Oryctolagus cuniculus
101108235 Ovis aries
100689342 Cricetulus griseus
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