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Browse our TLR3 Proteins (TLR3)

Full name:
Toll-Like Receptor 3 Proteins (TLR3)
On are 26 Toll-Like Receptor 3 (TLR3) Proteins from 10 different suppliers available. Additionally we are shipping TLR3 Antibodies (346) and TLR3 Kits (36) and many more products for this protein. A total of 418 TLR3 products are currently listed.
AI957183, CD283, IIAE2, zgc:123006
list all proteins Gene Name GeneID UniProt
TLR3 7098 O15455
TLR3 142980 Q99MB1
TLR3 364594  

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TLR3 Proteins (TLR3) by Origin

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Top referenced TLR3 Proteins

  1. Human TLR3 Protein expressed in Escherichia coli (E. coli) - ABIN2667591 : Bell, Botos, Hall, Askins, Shiloach, Segal, Davies: The molecular structure of the Toll-like receptor 3 ligand-binding domain. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 5 references for ABIN2667591

  2. Mouse (Murine) TLR3 Protein expressed in Human Cells - ABIN2007431 : Lafon, Megret, Lafage, Prehaud: The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA. in Journal of molecular neuroscience : MN 2006 (PubMed)
    Show all 4 references for ABIN2007431

  3. Mouse (Murine) TLR3 Protein expressed in Baculovirus infected Insect Cells - ABIN2007429 : Johnsen, Nguyen, Ringdal, Tryggestad, Bakke, Lien, Espevik, Anthonsen: Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. in The EMBO journal 2006 (PubMed)
    Show all 4 references for ABIN2007429

More Proteins for TLR3 Interaction Partners

Human Toll-Like Receptor 3 (TLR3) interaction partners

  1. TLR2 priming (via Pam3Csk4) would inhibit TLR4 (show TLR4 Proteins)-mediated responses while TLR3 priming (via Poly I:C) would enhance subsequent TLR4 (show TLR4 Proteins)-inflammatory signaling.

  2. this study shows that TLR3 signaling is regulated by miniMAVS, a 50 kDa isoform of MAVS (show MAVS Proteins)

  3. IFNgamma promotes double strabded RNA-induced TLR3-dependent apoptosis via upregulation of transcription factor Runx3 (show RUNX3 Proteins) in airway epithelial cells.

  4. In Japanese individuals, combined genotyping for the associated variants thus far identified; that is, HLA-A*02:06, TLR3 rs3775296 T/T and Rec114 rs16957893 CG, may help to predict the risk for cold medicine-related Stevens-Johnson syndrome /TEN with severe ocular complications

  5. c-Myc (show MYC Proteins) overexpression may increase sensitivity to poly(I:C)-induced tumor growth arrest and ROS (show ROS1 Proteins)-mediated apoptosis in neuroblastoma (show ARHGEF16 Proteins). This study demonstrates that c-Myc (show MYC Proteins) protein expression has an important role in TLR3-induced innate immune responses.

  6. The NF-kappaB (show NFKB1 Proteins) activated by dsRNA appears not to be the canonical p65 (show GORASP1 Proteins)/p50 (show CD40 Proteins) heterodimers.

  7. Leading to a STAT1 (show STAT1 Proteins)-IRF1 (show IRF1 Proteins) controlled upregulation of TLR3 expression in macrophages.

  8. This study showed that LR3 (show LRP5 Proteins) mRNA expression was correlated with good functional outcome at acute and subacute phases, and TLR3 was an independent predictor of clinical outcome in 90 days.

  9. In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1 (show GBP1 Proteins), TLR3, OAS1 (show OAS1 Proteins), EIF2AK2 (show EIF2AK2 Proteins), HLA-E (show HLAE Proteins), IFI6 (show IFI6 Proteins), and STAT1 (show STAT1 Proteins), showed higher expression in the islet core compared with the peri (show PLIN1 Proteins)-islet area containing the surrounding immune cells

  10. The results of the study suggest that TLR3 and TLR9 (show TLR9 Proteins) play a role in the pathogenesis of SLE, and have an impact on organ involvement in this disease.

Mouse (Murine) Toll-Like Receptor 3 (TLR3) interaction partners

  1. results reveal a novel CD40 (show CD40 Proteins)-dependent regulation of PD-L1 (show CD274 Proteins) trafficking induced upon TLR3 signaling that dictates its inhibitory activity.

  2. This study reveals novel insights into the pathophysiology of epilepsy and the contribution of TLR3 to disease progression.

  3. the activation of TLR3 promotes the loss of RGCs and their axons by elevating Rtca (show RTCD1 Proteins) levels in the retina. Also, the results presented in this study show that Rtca (show RTCD1 Proteins) regulates JNK3 (show MAPK10 Proteins) expression in the retina.

  4. identify iNOS (show NOS2 Proteins)/NO as an integral component of IFN-beta (show IFNB1 Proteins) production in response to dsRNA in hepatocytes in a pathway that involves the coordinated activities of TLR3/Trif (show RNF138 Proteins) and PKR (show EIF2AK2 Proteins)

  5. we found that Aire (show AIRE Proteins) up-regulated TLR3 expression and modulated the downstream cytokine expression and nuclear factor-kappaB (NF-kappaB (show NFKB1 Proteins)) of the TLR3 signaling pathway.

  6. synergy of TLR3 and 7 ligands could significantly enhance the function of DCs to present inactivated PRRSV antigen through TRIF (show RNF138 Proteins)/MyD88 (show MYD88 Proteins)-NF-kappaB (show NFKB1 Proteins) signaling pathway and be used as adjuvant candidate for the development of novel PRRS inactivated vaccine

  7. Our findings support a potential regulatory role of TLR3 in alcohol consumption.

  8. The results imply that recognition of resident viruses by TLR3 and TLR7 (show TLR7 Proteins) is required for protective immunity during gut (show GUSB Proteins) inflammation.

  9. TRIF (show RNF138 Proteins)-independent pathways can be involved in the downregulation of drug metabolizing enzymes and transporters through TLR4 (show TLR4 Proteins) and 3. JNK (show MAPK8 Proteins)-dependent mechanisms likely mediate this downregulation.

  10. Results show that toll (show TLR4 Proteins)/IL-1 (show IL1A Proteins) domain-containing adaptor inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins)) is essential for Toll (show TLR4 Proteins)-like receptors TLR3- and TLR4 (show TLR4 Proteins)-mediated innate immune responses in peritoneal mesothelial cells (PMCs).

Pig (Porcine) Toll-Like Receptor 3 (TLR3) interaction partners

  1. These data demonstrated that TLR2, TLR3 and TLR9 (show TLR9 Proteins) contribute to NF-kappaB (show NFKB1 Proteins) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Proteins).

  2. TLR3 is regulated differentially by different genotype 1 PRRSV strains and this seems to be related apparently to the replication levels of each strain, as well as, to the TNF-alpha (show TNF Proteins) inducing capability.

  3. 5 known non-synonymous single nucleotide polymorphisms (SNPs) were characterized in the coding sequences of the porcine TLR3 gene.

  4. Activation of porcine TLR3 signaling is important in stimulating effective responses to PRRSV infection.

Cow (Bovine) Toll-Like Receptor 3 (TLR3) interaction partners

  1. The results from this study demonstrate that expression of at least TLR3, TLR7 (show TLR7 Proteins) and TLR8 (show TLR8 Proteins) is stimulated upon bovine alpha-herpesvirus infection of the brain.

Rabbit Toll-Like Receptor 3 (TLR3) interaction partners

  1. TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.

  2. 18 SNPs of TLR3 were observed and only 4 polymorphic positions were detected in the domestic breeds and 14 non-synonymous substitutions were observed, most of them in the LRR molecules.

Zebrafish Toll-Like Receptor 3 (TLR3) interaction partners

  1. Binding energy (BE) calculation using MM/PBSA method from the TLR3- and TLR22-ligand complexes revealed an adequate binding affinity between TLR22-monomer and dsRNA as like as TLR3-dimer-dsRNA complex.

  2. Full-length tlr3 was functionally characterized.

TLR3 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Alternative names and synonyms associated with TLR3

  • toll-like receptor 3 (TLR3)
  • toll-like receptor 3 (Tlr3)
  • toll-like receptor 3 (tlr3)
  • AI957183 protein
  • CD283 protein
  • IIAE2 protein
  • zgc:123006 protein

Protein level used designations for Toll-Like Receptor 3 Proteins (TLR3)

toll-like receptor 3 , toll-like receptor 3-like , toll-like receptor 3 variant 1

471374 Pan troglodytes
100409573 Callithrix jacchus
7098 Homo sapiens
142980 Mus musculus
364594 Rattus norvegicus
482905 Canis lupus familiaris
100037937 Sus scrofa
281535 Bos taurus
422720 Gallus gallus
100135634 Cavia porcellus
100009024 Oryctolagus cuniculus
554258 Ovis aries
403126 Danio rerio
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