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Human TLR3 Protein expressed in Escherichia coli (E. coli) - ABIN2667591
Bell, Botos, Hall, Askins, Shiloach, Segal, Davies: The molecular structure of the Toll-like receptor 3 ligand-binding domain. in Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 5 references for ABIN2667591
Mouse (Murine) TLR3 Protein expressed in Human Cells - ABIN2007431
Lafon, Megret, Lafage, Prehaud: The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA. in Journal of molecular neuroscience : MN 2006
Show all 4 references for ABIN2007431
Mouse (Murine) TLR3 Protein expressed in Baculovirus infected Insect Cells - ABIN2007429
Johnsen, Nguyen, Ringdal, Tryggestad, Bakke, Lien, Espevik, Anthonsen: Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. in The EMBO journal 2006
Show all 4 references for ABIN2007429
TLR3 activation induces myofibroblastic differentiation of PROM1+ epithelial-mesenchymal hepatic progenitor cells in part via TGFbeta (show TGFB1 Proteins) pathway activation to promote biliary atresia-associated biliary fibrosis.
Tim-3 (show HAVCR2 Proteins) blockade in combination with TLR activation induces the expression of antiviral molecules without a significant increase in TNF-alpha (show TNF Proteins) or SOCS1 (show SOCS1 Proteins).
We found lower expression levels of TLR1 (show TLR1 Proteins), TLR3, TLR4 (show TLR4 Proteins), TLR7 (show TLR7 Proteins) and TLR9 (show TLR9 Proteins) in PBMCs from patients with ALL compared with those from control patients. We also observed that the PBMCs from patients with Pre-B and B ALL had lower TLR4 (show TLR4 Proteins) expression than controls
Activation of TLR3 by poly IC induces the IFI35 (show IFI35 Proteins) expression in Mesangial Cells
this study shows that TLR3 gene polymorphism is associated with hepatitis C virus infection and related cirrhosis and hepatocellular carcinoma in Saudi Arabia
The results showed that the genetic variants in TLR3 were associated with asthma-related phenotypes, including eosinophil counts, serum immunoglobulin E levels and lung function. However, there was no obvious association between the TLR3 SNPs and asthma
These data suggest a likely effect on the risk to infect HEPATITIS C, HEPATITIS B and develop HBV-related diseases WITH THE TLR3 gene
a possible association between chronic hepatitis B and TLR 3 gene (1377C/T) polymorphism
Data show that the toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly(I:C)) or toll-like receptor 4 (TLR4 (show TLR4 Proteins)) agonist lipopolysaccharide (LPS (show IRF6 Proteins)) increased the mRNA expression of TLR3, TLR4 (show TLR4 Proteins) and cytokines in mesenchymal stem cells (hMSCs).
This meta-analysis has thus revealed suggestive evidence for TLR3 rs3775291 as an associated marker for age-related macular degeneration in Caucasians but not in Asians.
identify iNOS (show NOS2 Proteins)/NO as an integral component of IFN-beta (show IFNB1 Proteins) production in response to dsRNA in hepatocytes in a pathway that involves the coordinated activities of TLR3/Trif (show RNF138 Proteins) and PKR (show EIF2AK2 Proteins)
we found that Aire (show AIRE Proteins) up-regulated TLR3 expression and modulated the downstream cytokine expression and nuclear factor-kappaB (NF-kappaB (show NFKB1 Proteins)) of the TLR3 signaling pathway.
synergy of TLR3 and 7 ligands could significantly enhance the function of DCs to present inactivated PRRSV antigen through TRIF (show RNF138 Proteins)/MyD88 (show MYD88 Proteins)-NF-kappaB (show NFKB1 Proteins) signaling pathway and be used as adjuvant candidate for the development of novel PRRS inactivated vaccine
Our findings support a potential regulatory role of TLR3 in alcohol consumption.
The results imply that recognition of resident viruses by TLR3 and TLR7 (show TLR7 Proteins) is required for protective immunity during gut (show GUSB Proteins) inflammation.
TRIF (show RNF138 Proteins)-independent pathways can be involved in the downregulation of drug metabolizing enzymes and transporters through TLR4 (show TLR4 Proteins) and 3. JNK (show MAPK8 Proteins)-dependent mechanisms likely mediate this downregulation.
Results show that toll (show TLR4 Proteins)/IL-1 (show IL1A Proteins) domain-containing adaptor inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins)) is essential for Toll (show TLR4 Proteins)-like receptors TLR3- and TLR4 (show TLR4 Proteins)-mediated innate immune responses in peritoneal mesothelial cells (PMCs).
during Respiratory syncytial virus infection, respiratory macrophages and dendritic cells mediate the production of IL-33 (show IL33 Proteins) in a TLR-dependent manner
TNFalpha (show TNF Proteins)-blockade stabilizes local airway hyperresponsiveness during TLR3/4-induced exacerbations in murine model of asthma.
Shock wave treatment protects from neuronal degeneration via TLR3 signaling and subsequent TLR4 (show TLR4 Proteins) downregulation in model of ischemic spinal cord injury.
These data demonstrated that TLR2, TLR3 and TLR9 (show TLR9 Proteins) contribute to NF-kappaB (show NFKB1 Proteins) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Proteins).
TLR3 is regulated differentially by different genotype 1 PRRSV strains and this seems to be related apparently to the replication levels of each strain, as well as, to the TNF-alpha (show TNF Proteins) inducing capability.
5 known non-synonymous single nucleotide polymorphisms (SNPs) were characterized in the coding sequences of the porcine TLR3 gene.
Activation of porcine TLR3 signaling is important in stimulating effective responses to PRRSV infection.
The results from this study demonstrate that expression of at least TLR3, TLR7 (show TLR7 Proteins) and TLR8 (show TLR8 Proteins) is stimulated upon bovine alpha-herpesvirus infection of the brain.
18 SNPs of TLR3 were observed and only 4 polymorphic positions were detected in the domestic breeds and 14 non-synonymous substitutions were observed, most of them in the LRR molecules.
Binding energy (BE) calculation using MM/PBSA method from the TLR3- and TLR22-ligand complexes revealed an adequate binding affinity between TLR22-monomer and dsRNA as like as TLR3-dimer-dsRNA complex.
Full-length tlr3 was functionally characterized.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
toll-like receptor 3
, toll-like receptor 3-like
, toll-like receptor 3 variant 1