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the DNA fragment containing the associated SNPs interacts through chromatin looping not only with TNFAIP3, but also with IL20RA (show IL20RA Proteins), located 680 kb upstream.
The findings suggest that TNFAIP3 protein may be an independent prognostic marker for poor survival, and a promising target for esophageal squamous cell carcinoma therapy.
Study demonstrates that the rs7749323 in the TNFAIP3 gene is strongly associated with the late onset myasthenia gravis(with positive AChR Ab but without thymoma).
Influenza a virus NS1 (show PTPN11 Proteins) has a role in inducing A20 contributes to viral replication by suppressing interferon (show IFNA Proteins)-induced antiviral response
Inductive regulation of A20 by glucocorticoid receptor (show NR3C1 Proteins) and NF-kappaB (show NFKB1 Proteins) contributes to cytokine repression in human airway smooth muscle.
Our study confirms the involvement of the TNFAIP3 tumor suppressor gene in classic Hodgkin lymphoma.
A20 may be a potential therapeutic target for DLBCL.
There is a significantly higher occurrence of the A20 rs143002189 polymorphism in diffuse large B cell lymphoma (DLBCL) compared to non-neoplastic controls and other types of B cell malignancies.
HMBA was able to increase prostratin-induced phosphorylation and degradation of NF-kappaB (show NFKB1 Proteins) inhibitor IkappaBalpha (show NFKBIA Proteins), thereby enhancing and prolonging prostratin-induced nuclear translocation of NF-kappaB (show NFKB1 Proteins), a prerequisite for stimulation of transcription initiation
A Japanese family case with juvenile onset Behcet's disease caused by TNFAIP3 mutation.
these data reveal a crucial role of A20 in regulating the immunomodulatory activities of mesenchymal stem cells.
Therefore, A20 acts as a novel endogenous regulator of STAT1 (show STAT1 Proteins) that prevents onset of enthesitis.
This study demonstrated that miR (show MLXIP Proteins)-136-5p affected the expression of A20 in IL-17 (show IL17A Proteins)-stimulated astrocytes.
Our data suggest that NAOs have a beneficial preventive effect in septic shock correlated with the enhancement of IL-10 (show IL10 Proteins) via the induction of A20 and COX-2.
Forced expression of A20 resulted in decreased expression of key markers of lipogenesis and adipogenesis, such as sterol regulatory element binding protein (show CNBP Proteins) 1c (SREBP-1c (show SREBF1 Proteins)) and adipogenesis (aP2 (show TFAP2A Proteins)), leading to less lipids accumulation in differentiated 3T3-L1 cells
these results suggest that Mycobacterium fortuitum-induced activation of host proinflammatory responses is negatively regulated through TLR2-dependent A20 expression.
knockdown of A20 in tumor site inhibited tumor growth at least through inducing the apoptosis of MDSCs. A20 might be a potential target in anticancer therapy.
MiR (show MLXIP Proteins)-221 directly targets A20, a master regulator of NF-kappaB (show NFKB1 Proteins) and MAPK (show MAPK1 Proteins) signaling, and thus represses inflammatory signaling. Restoration of A20 in macrophages abolished the stimulatory effect of miR (show MLXIP Proteins)-221 on production of proinflammatory cytokines.
A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.
Our results show that miR (show MLXIP Proteins)-873 elevates A20 levels and inhibits morphine-induced macrophage apoptosis.
Data show the characterization and deduced amino acid sequence analysis for A20 gene which expression increases in MDBK cells infected by BVDV-1. Also, regulatory regions for NF-kappaB (show NFKB1 Proteins) and Sp-1 (show SP1 Proteins) additionally to an ARE element for mRNA stability were detected
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
tumor necrosis factor, alpha-induced protein 3
, OTU domain-containing protein 7C
, TNF alpha-induced protein 3
, putative DNA-binding protein A20
, tumor necrosis factor alpha-induced protein 3
, tumor necrosis factor inducible protein A20
, zinc finger protein A20
, tumor necrosis factor induced protein 3