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These findings suggest that A-SAA is functionally linked to pulmonary inflammation in this O3 exposure model and that A-SAA could be an important systemic signal of O3 exposure to the CNS.-
study reports that truncated SAA1 proteins lacking N- and C-terminal sequences exhibit reduced proinflammatory activity and strongly suppress LPS (show TLR4 Proteins)-induced expression of IL-1beta (show IL1B Proteins), IL-6 (show IL6 Proteins), and TNF-alpha (show TNF Proteins) in macrophages
though the clearance rate of SAA was reduced in the absence of the HDL (show HSD11B1 Proteins) receptor, scavenger receptor class B type I (SR-BI), it remained significantly faster compared with that of apoA-I (show APOA1 Proteins) and apoA-II (show APOA2 Proteins), indicating a relatively minor role of SR-BI (show SCARB1 Proteins) in SAA's rapid clearance. These studies enhance our understanding of SAA metabolism and SAA's effects on AP-HDL (show HSD11B1 Proteins) composition and catabolism.
SAA and TLR4 (show TLR4 Proteins) have a role in skin inflammation
SAA is a potential new uremic toxin involved in uremia-related atherosclerosis through interaction with RAGE (show AGER Proteins).
Data indicate that SAA1 overexpressing mice (TG) show significant deficits in social behaviors, including impaired social recognition and reduced social interaction. Study detected exogenous SAA1 expression in the brain of TG mice, implying that liver-derived SAA1 migrates to the brain. Results show an increase in the accumulation of the 87kDa form of Abeta (show APP Proteins) in TG mice compared to wild type mice.
Mass spectrometry analysis of peptides derived from chemically crosslinked HDL (show HSD11B1 Proteins)-SAA particles detected multiple crosslinks between apoA1 (show APOA1 Proteins) and SAA, indicating close proximity (within 25 A) of these two proteins on the HDL (show HSD11B1 Proteins) surface, providing a molecular and structural mechanism for the simultaneous binding of heparin to apoA1 (show APOA1 Proteins) and SAA.
The findings identify SR-BII (show SCARB2 Proteins) as a functional SAA receptor that mediates SAA uptake and contributes to its proinflammatory signaling via the MAPK (show MAPK1 Proteins)-mediated signaling pathways.
Sustained, elevated levels of SAA1 were correlated with metabolic parameters and local cytokine expression in the liver following 16 weeks on the high-fat diet. We suggest that SAA1-derived amyloid deposition under long-term high-fat diet exposure may be associated with the complications of high-fat diet-induced obesity and metabolic disorders.
SAA inhibits osteoclast formation from mouse macrophages. SAA blocks RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis.
The Serum amyloid A (SAA)/formyl peptide receptor-like 1 (FPRL1 (show FPR2 Proteins)) contributed to pathogenesis of psoriasis by promoting keratinocyte proliferation and inflammation, thus providing a potential therapeutic target for disease therapy.
High SAA expression is associated with lung cancer.
SAA, PROZ (show PROZ Proteins), and C4BPB (show C4BPB Proteins) may serve as new potential biomarkers for TB
Novel truncated form of serum amyloid A is elevated in the plasma of Kawasaki disease (KD) when compared with Febrile control subjects. Future studies will evaluate its relevance as a diagnostic biomarker and its potential role in the pathophysiology of KD.
SR-A1 suppresses lung cancer metastasis by downregulating SAA1 production in tumor-associated macrophages (TAM (show CCNA1 Proteins)).
The SAA1.1 allele was found in four familial Mediterranean fever (show MEFV Proteins) patients, including two with AA amyloidosis.
genetic variants at the CRP (show CRP Proteins) and SAA1 loci independently affect both CRP (show CRP Proteins) and SAA levels, and their respective circulating levels act as suppressors.
Serum amyloid A could represent a novel marker of primary unexplained recurrent early pregnancy loss because affected women exhibited elevated levels of this protein.
The polymorphism of SAA1 is not associated with susceptibility and severity of Familial Mediterranean Fever (show MEFV Proteins) in Egyptian children
polymorphisms in the SAA2 gene are associated with milk production traits in Chinese Holstein cows
endometritis gives rise to a systemic acute phase response and an up-regulated endometrial gene expression of SAA and several pro-and anti-inflammatory cytokines
The levels of surfactant protein D and serum amyloid A protein in normal horses and those with bacterial pneumonia are reported.
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
serum amyloid A protein
, serum amyloid A1
, serum amyloid a protein
, serum amyloid A 2
, serum amyloid A-1 protein
, serum amyloid A
, serum amyloid A-3 protein
, tumor protein p53 inducible protein 4
, serum amyloid A2