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anti-Mouse (Murine) MTTP Antibodies:
anti-Rat (Rattus) MTTP Antibodies:
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Mouse (Murine) Monoclonal MTTP Primary Antibody for IF, WB - ABIN968716
Chen, Newberry, Norris, Xie, Luo, Kennedy, Davidson: ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice. in Journal of lipid research 2008
Show all 6 Pubmed References
Cow (Bovine) Polyclonal MTTP Primary Antibody for WB - ABIN2781495
Lundahl, Skoglund-Andersson, Caslake, Bedford, Stewart, Hamsten, Packard, Karpe: Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles. in American journal of physiology. Endocrinology and metabolism 2006
Show all 3 Pubmed References
promotes assembly and secretion of human apolipoprotein B (show APOB Antibodies)
the phospholipid transfer activity of MTP is sufficient for the assembly and secretion of primordial apoB (show APOB Antibodies) lipoproteins
analysis of developmental expression and nutritional regulation of zebrafish homolog to mammalian microsomal triglyceride transfer protein large subunit
In a genetic study of lipid transport and metabolism, larval levels of microsomal triglyceride transfer protein (Mtp), the protein responsible for packaging triacylglycerol and beta-lipoproteins into lipoprotein particles, are unchanged by feeding.
MTTP is regulated by apo A-IV in manner to promote increased packaging of triglyceride into chylomicron core, which may be important in neonatal fat absorption.
There appears to be an interaction between the porcine MTTP genotype and the type of fat source in the pig diet, which would agree with the previous results on the biology of MTTP biology.
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Antibodies), ApoE (show APOE Antibodies), MTP, and LDLR (show LDLR Antibodies), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
after calving the apolipoprotein B(100 (show APOB Antibodies)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E (show APOE Antibodies) messenger RNA abundance were higher in the liver
measurements of the transfer of phospholipids (PLs (show CTSC Antibodies)) and cholesteryl esters (CEs)to acceptor vesicles by purified MTP showed TAG transfer activity was the most robust, and CE and PL transfer activities were 60-71% and 5-13% of the TAG transfer activity
Fasting upregulates Fpn1 (show SLC40A1 Antibodies) expression in spleen and peritoneal macrophages, probably via a ghrelin (show GHRL Antibodies)/GHSR1a/MAPK (show MAPK1 Antibodies) signaling pathway.
Microsomal triglyceride transfer protein protein plays a critical role in lipid droplet maturation, but does not regulate total body fat accumulation.
Expression of Hepcidin (show HAMP Antibodies) and Ferroportin (show SLC40A1 Antibodies) in the Placenta, and Ferritin (show FTL Antibodies) and Transferrin Receptor 1 (show TFR Antibodies) Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes
findings show that ferroportin (show SLC40A1 Antibodies) expression by macrophages at the site of injury represents a requirement for appropriate activation of myogenic precursors and eventual healing of injured skeletal muscle
data provide the first in vivo evidence of the transcriptional regulatory activity of beta-apocarotenoids and identify microsomal triglyceride transfer protein and its transcription factors as the targets of their action. This study demonstrates that beta-carotene induces a feed-forward mechanism in the placenta to enhance the assimilation of beta-carotene for proper embryogenesis.
The results suggest that physiologic hepcidin (show HAMP Antibodies) levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.
PHARMACOLOGICAL STUDY OF NEW COMPOUNDS ACTING AS REGULATORS OF 18-KDA TRANSLOCATOR PROTEIN (show TSPO Antibodies) LIGANDS
In Angiotensin II treated mice, duodenal divalent metal transporter-1 (show SLC11A2 Antibodies) and ferroportin (show SLC40A1 Antibodies) expression levels were increased and hepatic hepcidin (show HAMP Antibodies) mRNA expression and serum hepcidin (show HAMP Antibodies) concentration were reduced.
Intestine-specific MTP (show LAPTM4A Antibodies) and global ACAT2 (show SOAT2 Antibodies) deficiency lowers acute cholesterol absorption with chylomicrons and HDLs (show CSF1R Antibodies)
Mice infected with Salmonella typhimurium have increased duodenal expression of the iron exporter ferroportin-1 (show SLC40A1 Antibodies), consistent with increased uptake of dietary iron.
two new hypolipidemic patients with very low plasma triglyceride and apolipoprotein B (apoB (show APOB Antibodies)) levels with plasma lipid profiles similar to abetalipoproteinemia (ABL (show ABL1 Antibodies)) patients, are reported.
results of this study, examining a cohort of obese children, suggest that the genetic variation at MTTP rs2306986 was associated with higher susceptibility to NAFLD (show TSC2 Antibodies)
Data suggest that amphipathic beta-strands in 200 N-terminal residues of beta1 domain of APOB (show APOB Antibodies) are required for secretion of lipid-rich or lipid-poor particles; residues 300-700 or 1050-1500 of beta1 domain appear to be required for secretion of lipid-rich particles; MTTP is required for secretion of intact APOB (show APOB Antibodies) but not of truncated APOB (show APOB Antibodies). (APOB (show APOB Antibodies) = apolipoprotein B (show APOB Antibodies); MTTP = microsomal triglyceride transfer protein)
In chronic hepatitis C patients infected with HCV genotype 3 and with the TT/GT genotype of the MTTP -493G/T SNP, a significant increase in hepatic steatosis was observed, which may indicate that this SNP has a significant influence on the accumulation of triglycerides in hepatocytes.
High expression of MTTP is associated with high carotid intima-media thickness.
MTP Gene Variants are associated with Homozygous Familial Hypercholesterolemia.
the N-terminal domain of MTP is important for its lipid transfer activity
These studies indicated that SAP18 (show SAP18 Antibodies) expression enhanced the recruitment of mSin3A in coordination with TRIB1 (show TRIB1 Antibodies) to MTTP regulatory elements and increased MTTP expression.
Results present evidence that MTTP polymorphisms could modulate the lipid homeostasis to determine the serum lipids and increase risk of non-alcoholic fatty liver disease.
Findings from meta-analysis indicate that the MTP -493G/T polymorphism may contribute to the development of non-alcoholic fatty liver disease. Thus, the MTP -493G/T polymorphism may be a biomarker for the early detection of the disease.
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
microsomal triacylglycerol transfer protein
, microsomal triglyceride transfer protein
, microsomal triglyceride transfer protein large subunit
, microsomal triglyceride transfer protein (large polypeptide, 88kDa)
, microsomal triglyceride transfer protein B
, microsomal triglyceride transfer protein, large subunit
, SLC11A3 iron transporter
, ferroportin 1
, iron-regulated transporter 1
, metal transporter protein 1
, metal transporting protein 1
, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
, solute carrier family 39 (iron-regulated transporter), member 1
, solute carrier family 40 member 1