MTTP antibody (N-Term)

Catalog No. ABIN2781495

There are 3+ publications for this product available. The Rabbit Polyclonal anti-MTTP antibody is suitable to detect MTTP in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Rabbit. It has been validated for WB.

Quick Overview for MTTP antibody (N-Term) (ABIN2781495)

Target: MTTP (Microsomal Triglyceride Transfer Protein (MTTP))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTTP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MTTP Antibody

Binding Specificity: N-Term

Purpose: MTTP Antibody - N-terminal region

Sequence: MILLAVLFLC FISSYSASVK GHTTGLSLNN DRLYKLTYST EVLLDRGKGK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MTTP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MTTP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8105385

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-MTTP antibody (ABIN2781495)

Lee, Bao, Ishikawa, Wang, Lim: "Cardiomyocyte Regulation of Systemic Lipid Metabolism by the Apolipoprotein B-Containing Lipoproteins in Drosophila." in: PLoS genetics, Vol. 13, Issue 1, pp. e1006555, (2017) (PubMed).

Ward, Dail, Chambers: "In Vitro effect of DDE exposure on the regulation of lipid metabolism and secretion in McA-RH7777 hepatocytes: A potential role in dyslipidemia which may increase the risk of type 2 diabetes mellitus." in: Toxicology in vitro : an international journal published in association with BIBRA, Vol. 37, pp. 9-14, (2016) (PubMed).

Lundahl, Skoglund-Andersson, Caslake, Bedford, Stewart, Hamsten, Packard, Karpe: "Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles." in: American journal of physiology. Endocrinology and metabolism, Vol. 290, Issue 4, pp. E739-45, (2006) (PubMed).

Target Details for MTTP

Target: MTTP (Microsomal Triglyceride Transfer Protein (MTTP))

Alternative Name: MTTP

Background:

Background Information: MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.

Gene Name: Microsomal triglyceride transfer protein

Alternative Symbols: ABL, MTP

Protein Name: Microsomal triglyceride transfer protein large subunit

Molecular Weight: 99 kDa

Gene ID: 4547

NCBI Accession: NP_000244

UniProt: P55157

Pathways: Transition Metal Ion Homeostasis