Browse our Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Proteins (SLC40A1)

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Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Proteins (SLC40A1)
On are 5 Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) Proteins from 4 different suppliers available. Additionally we are shipping Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Antibodies (84) and Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Kits (43) and many more products for this protein. A total of 138 Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 products are currently listed.
A. THALIANA CATION DIFFUSION FACILITATOR 1, ARABIDOPSIS IRON-REGULATED TRANSPORTER 1, ARABIDOPSIS THALIANA IRON-REGULATED PROTEIN 1, ATCDF1, ATIREG1, ATIRT1, ATMTP1, Dusg, F19D11.8, FERROPORTIN 1, Fpn1, HFE4, IREG1, iron-regulated transporter 1, iron regulated 1, MGC82700, MST079, MTP, MTP1, Ol5, Pcm, Slc11a3, Slc39a1, SLC40A1, T16H5.50, T16H5_50, T19C21.5, T19C21_5, weh, ZAT1, zinc transporter of Arabidopsis thaliana, ZINC TRANSPORTER OF ARABIDOPSIS THALIANA 1, ZINC TRANSPORTER ZAT
list all proteins Gene Name GeneID UniProt
SLC40A1 30061 Q9NP59
SLC40A1 53945 Q9JHI9
Rat SLC40A1 SLC40A1 170840 Q923U9

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Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Proteins (SLC40A1) by Origin

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More Proteins for Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 Interaction Partners

Zebrafish Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

  1. Functional impact of mammalian ferroportin mutations studied in zebrafish.

Arabidopsis thaliana Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

  1. role of ABCG37, IRT1 and FRO2 in root Fe2+ transport systems

  2. role of IRT1 (show PARP3 Proteins) in iron uptake

  3. these results suggest that the His-loop of MTP1 acts as a sensor of cytosolic zinc to maintain an essential level in the cytosol and that the dysfunction of the loop results in an uncontrolled accumulation of zinc in the vacuoles of root cells.

  4. Our results reveal a role of SNX1 (show SNX1 Proteins) for the correct trafficking of IRT1 (show PARP3 Proteins) and, thus, for modulating the activity of the iron uptake machinery

  5. This work establishes a functional link between the dynamics and the lateral polarity of IRT1 (show PARP3 Proteins) and the transport of its substrates, and identifies a molecular mechanism driving polar localization of a cell surface protein (show CD28 Proteins) in plants.

  6. IDF1 directly regulates IRT1 (show PARP3 Proteins) degradation through its RING-type E3 ligase activity.

  7. Data indicate that steady-state mRNA abundance for three representative Fe homeostasis genes, IRT1 (show PARP3 Proteins), bHLH39, and FER1 (show FTH1 Proteins), oscillated in light/dark (LD) cycles or warm/cold environmental cycles.

  8. AtIRT1 transports nicekl (Ni(2 (show VMP1 Proteins)+)) in roots, and strongly suggest that Ni accumulation is further accelerated by AtIRT1 that is expressed in response to excess Ni.

  9. These data suggest a model in which monoubiquitin-dependent internalization/sorting and turnover keep the plasma membrane pool of IRT1 (show PARP3 Proteins) low to ensure proper iron uptake and to prevent metal toxicity.

  10. IRT1 and FRO2 genes are upregulated under iron starvation.

Human Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

  1. Reduced expression of ferroportin mRNA identifies a subset of infertile women and may constitute a target for therapy.

  2. FPN1 cycles as a monomer within the endocytic/plasma membrane compartment and responds to its physiological inhibitor, Hepc (show HAMP Proteins), in both control and ferroportin disease (FD) cells. However, in FD, FPN1 fails to reach the cell surface when cells undergo high iron turnover.

  3. These results suggest that FPN1 exports iron received from the iron chaperone PCBP2 (show PCBP2 Proteins). Therefore, it was found that PCBP2 (show PCBP2 Proteins) modulates cellular iron export, which is an important physiological process.

  4. All these findings suggest that in erythroid cells FPN1 could be part of the signaling pathway through which the erythron communicates iron needs to expand the erythroid compartment regardless of systemic iron level.

  5. Mir (show MLXIP Proteins)-20a controls expression of the iron exporter ferroportin (FPN1) by binding to highly conserved target sites in its 3'-untranslated region. Expression of miR (show MLXIP Proteins)-20a is inversely correlated to FPN1 in lung cancer.

  6. The concentration of functional membrane-associated ferroportin is controlled by its ligand, the iron-regulatory hormone hepcidin (show HAMP Proteins), and fine-tuned by regulatory mechanisms serving iron homeostasis, oxygen utilization, host defense, and erythropoiesis.

  7. Low hepcidin (show HAMP Proteins) and high ferroportin expression by erythroblasts and macrophages were seen in iron deficiency anemia, while the opposite was true in anemia of chronic disorders.

  8. Erythroblasts from Beta-thalassemia patients showed a significantly reduced expression of total MTP1 protein.

  9. Several family members had hemochromatosis (show HFE Proteins) and hyperferritinemia associated with a SLC40A1 deletion in exon 5(485_487delTTG) resulting in the deletion of a valine residue (p.V162del). This is the 1st Spanish family reported with this European mutation.

  10. TLR4 (show TLR4 Proteins) dependent macrophage signaling is controlled via hepcidin (show HAMP Proteins)-ferroportin1 axis by influencing TLR4 (show TLR4 Proteins)-lipid raft interactions

Mouse (Murine) Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) interaction partners

  1. findings show that ferroportin expression by macrophages at the site of injury represents a requirement for appropriate activation of myogenic precursors and eventual healing of injured skeletal muscle

  2. The results suggest that physiologic hepcidin (show HAMP Proteins) levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.

  3. In Angiotensin II treated mice, duodenal divalent metal transporter-1 (show SLC11A2 Proteins) and ferroportin expression levels were increased and hepatic hepcidin (show HAMP Proteins) mRNA expression and serum hepcidin (show HAMP Proteins) concentration were reduced.

  4. Mice infected with Salmonella typhimurium have increased duodenal expression of the iron exporter ferroportin-1, consistent with increased uptake of dietary iron.

  5. Results suggest that reduction in ferroportin levels in Alzheimer's disease brains are likely associated with cerebral ischaemia, inflammation, loss of neurons due to protein misfolding, senile plaque formation and possibly ageing process itself

  6. Oral iron failed to be utilized by Fpn-KO mice and was retained in enterocytes, irrespective of the iron source. Ferroportin-dependent efflux from enterocytes controls duodenal iron absorption.

  7. Genetic interactions between Cp, Mon1a (show MON1A Proteins), and the Slc40a1 locus are involved in iron metabolism.

  8. Hypoxia signal, stimulated erythropoietin (show EPO Proteins), which affected iron absorption by stabilizing duodenal ferroportin.

  9. A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin (show HAMP Proteins) remains labile and available to down-regulate Fpn1.

  10. Nitric oxide up-regulated the expression of ferroportin-1 (Fpn1), the major cellular iron exporter, in mouse and human cells.

Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) Protein Profile

Protein Summary

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).

Alternative names and synonyms associated with Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1)

  • solute carrier family 40 (iron-regulated transporter), member 1 (slc40a1)
  • solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1)
  • Fe(2+) transport protein 1 (IRT1)
  • metal tolerance protein 1 short form (ZAT)
  • solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)
  • solute carrier family 40 member 1 (IREG1)
  • ATCDF1 protein
  • ATIREG1 protein
  • ATIRT1 protein
  • ATMTP1 protein
  • Dusg protein
  • F19D11.8 protein
  • FERROPORTIN 1 protein
  • Fpn1 protein
  • HFE4 protein
  • IREG1 protein
  • iron-regulated transporter 1 protein
  • iron regulated 1 protein
  • MGC82700 protein
  • MST079 protein
  • MTP protein
  • MTP1 protein
  • Ol5 protein
  • Pcm protein
  • Slc11a3 protein
  • Slc39a1 protein
  • SLC40A1 protein
  • T16H5.50 protein
  • T16H5_50 protein
  • T19C21.5 protein
  • T19C21_5 protein
  • weh protein
  • ZAT1 protein
  • zinc transporter of Arabidopsis thaliana protein

Protein level used designations for SLC40A1

ferroportin-1 , ferroportin1 , iron-regulated transporter , solute carrier family 39 (iron-regulated transporter), member 1 , solute carrier family 40 member 1 , weissherbst , solute carrier family 40 (iron-regulated transporter), member 1 , ferroportin , solute carrier family 40 member 1-like , iron regulated gene 1 , putative ferroportin 1 variant IIIB , solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 , SLC11A3 iron transporter , duodenal-specific , ferroportin 1 , iron-regulated transporter 1 , metal transporter protein 1 , metal transporting protein 1 , polycythaemia , CAR1 , cell adhesion regulator

58153 Danio rerio
423984 Gallus gallus
446661 Xenopus laevis
459821 Pan troglodytes
527023 Bos taurus
713321 Macaca mulatta
785185 Bos taurus
100036732 Xenopus (Silurana) tropicalis
100172551 Pongo abelii
100028485 Monodelphis domestica
100069190 Equus caballus
100474381 Ailuropoda melanoleuca
100588979 Nomascus leucogenys
827713 Arabidopsis thaliana
819293 Arabidopsis thaliana
30061 Homo sapiens
53945 Mus musculus
478837 Canis lupus familiaris
100512076 Sus scrofa
170840 Rattus norvegicus
818427 Arabidopsis thaliana
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