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anti-Human GRHL2 Antibodies:
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Human Polyclonal GRHL2 Primary Antibody for ICC, IF - ABIN4316153
Varma, Cao, Tagne, Lakshminarayanan, Li, Friedman, Morell, Warburton, Kotton, Ramirez: The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. in The Journal of biological chemistry 2012
Show all 8 Pubmed References
Human Polyclonal GRHL2 Primary Antibody for ELISA, WB - ABIN566411
Kang, Chen, Kim, Kang, Park: Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells. in Oncogene 2009
Show all 4 Pubmed References
Human Polyclonal GRHL2 Primary Antibody for IF, WB - ABIN529152
Dompe, Rivers, Li, Cordes, Schwickart, Punnoose, Amler, Seshagiri, Tang, Modrusan, Davis: A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2011
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Silencing of GRHL2 expression in non-tumorigenic kidney cell line results in increased cell proliferation, increased resistance to apoptosis, as well as changes in the levels of selected proteins involved in the pathogenesis of clear cell renal cell carcinoma (show MOK Antibodies) (ccRCC). These changes support the potential role for GRHL2 as a suppressor of ccRCC.
Results demonstrate a mechanistic role for GRHL2 in promoting anoikis through metabolic alterations.
GRHL2 maintained AR expression in multiple prostate cancer model systems, was required for cell proliferation, enhanced AR's transcriptional activity, and colocated with AR at specific sites on chromatin to regulate genes relevant to disease progression.
Studies indicate that Grainyhead-like transcription factor 2 (show HNF1B Antibodies) (GRHL2) controls the expression of E-cadherin (CDH1 (show CDH1 Antibodies)) required for adherens junctions and possibly regulates the expression of claudin-4 (CLDN4 (show CLDN4 Antibodies)) in tight junctions.
results indicated GRHL2 might be a noise-induced hearing loss (NIHL) susceptibility gene, but the effect of POU4F3 (show POU4F3 Antibodies) on NIHL could only be detected when taking noise exposure into account and their effects were enhanced by higher levels of noise exposure
These data are indicative for a strong oncogenic potential of the GRHL2 gene in epithelial ovarian cancer cells displaying either epithelial (A2780s) or mesenchymal (SKOV3) phenotypes.
marked overlap of dyskeratosis congenita with four other genetic syndromes, confounding accurate diagnosis and subsequent management. Patients with clinical features of dyskeratosis congenita need to have genetic analysis of USB1 (show USB1 Antibodies), LIG4 (show LIG4 Antibodies) and GRHL2 in addition to the classical dyskeratosis congenita genes and telomere length measurements.
In this review, we summarized recent progress on grainyhead-like 2 in development and cancer in order to get an insight into the regulation network of grainyhead-like 2 and understand the roles of grainyhead-like 2 in various cancers.
A loss or strong reduction in GRHL2 expression appears to be a characteristic of cervical cancer, suggesting that GRHL2 down-regulation is a necessary step during cervical carcinogenesis.
In skin from psoriasis patients, the effect of miR (show MLXIP Antibodies)-194 on cell proliferation and differentiation was significantly reversed by overexpression of GRHL2. Moreover, the expression of miR (show MLXIP Antibodies)-194 and GRHL2 was inversely correlated in psoriasis lesional skin. Taken together, our results suggest that miR (show MLXIP Antibodies)-194 inhibits the proliferation and promotes the differentiation of keratinocytes through targeting GRHL2.
GRHL2 promotes the epithelial nature of non-neural ectoderm during dynamic events of neural tube formation by both activating key epithelial genes and actively suppressing epithelial-mesenchymal (EMT (show ITK Antibodies)) transition through novel downstream EMT (show ITK Antibodies) suppressors.
a Grhl2/Ovol2 (show OVOL2 Antibodies) network controls Cldn4 (show CLDN4 Antibodies) and Rab25 (show RAB25 Antibodies) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity.
expression of GRHL2 is directly suppressed by the ZEB1 (show ZEB1 Antibodies), which in turn is a direct target for repression by GRHL2, suggesting that the EMT (show ITK Antibodies) transcription factors GRHL2 and ZEB1 (show ZEB1 Antibodies) form a double negative regulatory feedback loop
Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT (show ITK Antibodies) and tumor progression
the results indicate that Grhl2 regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 Antibodies) and Cldn4 (show CLDN4 Antibodies), as well as of Rab25 (show RAB25 Antibodies), which increases the Cldn4 (show CLDN4 Antibodies) protein and its localization at TJs
Grhl2 and Nkx2-1 (show NKX2-1 Antibodies) bind to each other's promoter in vivo, forming a positive feedback regulatory loop.
Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse
tissue closure defects in Grhl2 mutants are similar to that of AP-2alpha (show TFAP2A Antibodies) null mutants and AP-2alpha (show TFAP2A Antibodies) has been shown to bind to the promoter of E-cadherin (show CDH1 Antibodies)
Both GRHL2 and GRHL3 (show GRHL3 Antibodies) bind to and regulate expression of the wound repair gene Rho GEF (show ARHGEF2 Antibodies) 19, but regulation of the barrier forming gene, Transglutaminase 1 (TGase1 (show TGM1 Antibodies)), is unique to GRHL3 (show GRHL3 Antibodies).
The data showed that midbrain-hindbrain boundary maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets.
This work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss.
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).
grainyhead-like 2 (Drosophila)
, transcription factor CP2-like 3
, brother of mammalian grainyhead
, grainyhead-like protein 2 homolog
, grainyhead like 2
, grainyhead-like 2
, grainyhead-like 2b protein