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Browse our anti-GRHL2 (GRHL2) Antibodies

Full name:
anti-Grainyhead-Like 2 (Drosophila) Antibodies (GRHL2)
On are 36 Grainyhead-Like 2 (Drosophila) (GRHL2) Antibodies from 10 different suppliers available. Additionally we are shipping GRHL2 Proteins (5) and many more products for this protein. A total of 46 GRHL2 products are currently listed.
0610015A08Rik, BOM, DFNA28, grhl2, RGD1561191, si:dkey-21k18.2, Tcfcp2l3, TFCP2L3
list all antibodies Gene Name GeneID UniProt
GRHL2 79977 Q6ISB3
GRHL2 252973 Q8K5C0
GRHL2 299979  

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anti-Human GRHL2 Antibodies:

anti-Mouse (Murine) GRHL2 Antibodies:

anti-Rat (Rattus) GRHL2 Antibodies:

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Top referenced anti-GRHL2 Antibodies

  1. Human Polyclonal GRHL2 Primary Antibody for ICC, IF - ABIN4316153 : Varma, Cao, Tagne, Lakshminarayanan, Li, Friedman, Morell, Warburton, Kotton, Ramirez: The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. in The Journal of biological chemistry 2012 (PubMed)
    Show all 8 references for ABIN4316153

  2. Human Polyclonal GRHL2 Primary Antibody for ELISA, WB - ABIN566411 : Kang, Chen, Kim, Kang, Park: Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells. in Oncogene 2009 (PubMed)
    Show all 4 references for ABIN566411

  3. Human Polyclonal GRHL2 Primary Antibody for IF, WB - ABIN529152 : Dompe, Rivers, Li, Cordes, Schwickart, Punnoose, Amler, Seshagiri, Tang, Modrusan, Davis: A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 2 references for ABIN529152

  4. Chicken Polyclonal GRHL2 Primary Antibody for IHC, WB - ABIN2778358 : Van Laer, Van Eyken, Fransen, Huyghe, Topsakal, Hendrickx, Hannula, Mäki-Torkko, Jensen, Demeester, Baur, Bonaconsa, Mazzoli, Espeso, Verbruggen, Huyghe, Huygen, Kunst, Manninen, Konings, Diaz-Lacava, Steffens, Wienker, Pyykkö, Cremers, Kremer, Dhooge, St: The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment. in Human molecular genetics 2008 (PubMed)

More Antibodies against GRHL2 Interaction Partners

Human Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

  1. A loss or strong reduction in GRHL2 expression appears to be a characteristic of cervical cancer, suggesting that GRHL2 down-regulation is a necessary step during cervical carcinogenesis.

  2. In skin from psoriasis patients, the effect of miR (show MLXIP Antibodies)-194 on cell proliferation and differentiation was significantly reversed by overexpression of GRHL2. Moreover, the expression of miR (show MLXIP Antibodies)-194 and GRHL2 was inversely correlated in psoriasis lesional skin. Taken together, our results suggest that miR (show MLXIP Antibodies)-194 inhibits the proliferation and promotes the differentiation of keratinocytes through targeting GRHL2.

  3. A novel connection between GRHL2 and miR (show MLXIP Antibodies)-200 in oral cancer.Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells.

  4. GRHL2 genetic polymorphisms, rs611419 and rs10955255, have a protective role against sudden sensorineural hearing loss (SSHL) and reduce the risk of SSHL. However, rs6989650 is not associated with SSHL.

  5. This study showed that Mendelian sensorineural hearing loss exhibits vestibular dysfunction, including DFNA9 (show COCH Antibodies), DFNA11 (show MYO7A Antibodies), DFNA15 (show POU4F3 Antibodies) and DFNA28.

  6. study demonstrates that loss of GRHL2 increases the levels of histone mark H3K27me3 on promoters and GRHL2-binding sites at miR (show MLXIP Antibodies)-200b/a and E-cadherin (show CDH1 Antibodies) genes. These findings support GRHL2 as a pivotal gatekeeper of EMT (show ITK Antibodies) in EOC via miR (show MLXIP Antibodies)-200-ZEB1 (show ZEB1 Antibodies).

  7. Taken together, our results demonstrate a role for miR (show MLXIP Antibodies)-217 in the regulation of keratinocyte differentiation, partially through the regulation of GRHL2.

  8. Genetic variations in the EYA4 (show EYA4 Antibodies), GRHL2 and DFNA5 (show DFNA5 Antibodies) genes and their interactions with occupational noise exposure may play an important role in the incidence of noise-induced hearing loss (NIHL).

  9. GRHL1 (show GRHL1 Antibodies), GRHL2, and GRHL3 (show GRHL3 Antibodies) have roles in cellular proliferation, differentiation, adhesion, and polarity and may promote cancer or be tumor suppressors [review]

  10. The p63 (show RPE65 Antibodies) gene is regulated by GRHL2 through reciprocal feedback and determines the epithelial phenotype in human keratinocytes.

Mouse (Murine) Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

  1. GRHL2 promotes the epithelial nature of non-neural ectoderm during dynamic events of neural tube formation by both activating key epithelial genes and actively suppressing epithelial-mesenchymal (EMT (show ITK Antibodies)) transition through novel downstream EMT (show ITK Antibodies) suppressors.

  2. a Grhl2/Ovol2 (show OVOL2 Antibodies) network controls Cldn4 (show CLDN4 Antibodies) and Rab25 (show RAB25 Antibodies) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia

  3. Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity.

  4. expression of GRHL2 is directly suppressed by the ZEB1 (show ZEB1 Antibodies), which in turn is a direct target for repression by GRHL2, suggesting that the EMT (show ITK Antibodies) transcription factors GRHL2 and ZEB1 (show ZEB1 Antibodies) form a double negative regulatory feedback loop

  5. Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT (show ITK Antibodies) and tumor progression

  6. the results indicate that Grhl2 regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 Antibodies) and Cldn4 (show CLDN4 Antibodies), as well as of Rab25 (show RAB25 Antibodies), which increases the Cldn4 (show CLDN4 Antibodies) protein and its localization at TJs

  7. Grhl2 and Nkx2-1 (show NKX2-1 Antibodies) bind to each other's promoter in vivo, forming a positive feedback regulatory loop.

  8. Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse

  9. tissue closure defects in Grhl2 mutants are similar to that of AP-2alpha (show TFAP2A Antibodies) null mutants and AP-2alpha (show TFAP2A Antibodies) has been shown to bind to the promoter of E-cadherin (show CDH1 Antibodies)

  10. Both GRHL2 and GRHL3 (show GRHL3 Antibodies) bind to and regulate expression of the wound repair gene Rho GEF (show ARHGEF2 Antibodies) 19, but regulation of the barrier forming gene, Transglutaminase 1 (TGase1 (show TGM1 Antibodies)), is unique to GRHL3 (show GRHL3 Antibodies).

Zebrafish Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

  1. The data showed that midbrain-hindbrain boundary maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets.

  2. This work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss.

GRHL2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).

Alternative names and synonyms associated with GRHL2

  • grainyhead-like 2 (Drosophila) (GRHL2) antibody
  • grainyhead-like 2 (Drosophila) (Grhl2) antibody
  • grainyhead-like 2b (Drosophila) (grhl2b) antibody
  • 0610015A08Rik antibody
  • BOM antibody
  • DFNA28 antibody
  • grhl2 antibody
  • RGD1561191 antibody
  • si:dkey-21k18.2 antibody
  • Tcfcp2l3 antibody
  • TFCP2L3 antibody

Protein level used designations for GRHL2

grainyhead-like 2 (Drosophila) , transcription factor CP2-like 3 , brother of mammalian grainyhead , grainyhead-like protein 2 homolog , grainyhead like 2 , grainyhead-like 2 , grainyhead-like 2b protein

464320 Pan troglodytes
706549 Macaca mulatta
100056140 Equus caballus
429506 Gallus gallus
79977 Homo sapiens
481985 Canis lupus familiaris
519918 Bos taurus
252973 Mus musculus
299979 Rattus norvegicus
100034503 Danio rerio
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