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anti-Mouse (Murine) GRLF1 Antibodies:
anti-Human GRLF1 Antibodies:
anti-Rat (Rattus) GRLF1 Antibodies:
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Human Polyclonal GRLF1 Primary Antibody for IHC (p), IHC - ABIN408537
Eberwein, Laird, Schulz, Reinhard, Steinberg, Tomakidi: Modulation of focal adhesion constituents and their down-stream events by EGF: On the cross-talk of integrins and growth factor receptors. in Biochimica et biophysica acta 2015
Human Polyclonal GRLF1 Primary Antibody for IHC (p) - ABIN5579387
Li, Li, Zhou, Wang, Wang, Zhao, Cui, Ren, Dong, Chen: Abnormal expression of p190RhoGAP in colorectal cancer patients with poor survival. in American journal of translational research 2016
Novel mercaptoacetamide-based class II histone deacetylase (show HDAC1 Antibodies) inhibitor HDACIW2 treatment regulated the levels of RasGRF1 (show RASGRF1 Antibodies) and p-ERK (show EPHB2 Antibodies), and that W2 requires RasGRF1 (show RASGRF1 Antibodies) and ERK (show EPHB2 Antibodies) signaling to alter dendritic spine formation, suggesting that W2 regulates dendritic spine formation via a RasGRF1 (show RASGRF1 Antibodies)/ERK (show EPHB2 Antibodies)-dependent signaling pathway
p190A acts as a modulator of Rho GTPases in a localized area around the cilia to permit the dynamic actin rearrangement required for cilia elongation.
Data (including data from studies in knockout mice) suggest mechanisms involving RasGRF1 (show RASGRF1 Antibodies) exist to regulate hypothalamic-pituitary-adrenal axis in early-adolescent females; such mechanisms appear absent in younger/older female or adolescent male mice.
VLDLR (show VLDLR Antibodies) requires RasGRF1 (show RASGRF1 Antibodies)/CaMKII (show CAMK2G Antibodies) to alter dendritic spine formation.
Study suggests a complex role of ERK (show EPHB2 Antibodies)-dependent and Ras-GRF1 (show RASGRF1 Antibodies)-dependent signaling in corticostriatal plasticity, highlights differences between synaptic mechanisms in naive slices and dopamine-depleted preparations from L-DOPA-treated dyskinetic animals
RasGrf1 (show RASGRF1 Antibodies) is an important upstream component of signal transduction pathways regulating Pttg1 (show PTTG1 Antibodies) expression and controlling beta cell development and physiological responses.
CARD9 (show CARD9 Antibodies) regulates H-Ras (show HRAS Antibodies) activation by linking Ras-GRF1 (show RASGRF1 Antibodies) to H-Ras (show HRAS Antibodies), which mediates Dectin-1 (show CLEC7A Antibodies)-induced extracellular signal-regulated protein kinase (show CDK7 Antibodies) (ERK (show EPHB2 Antibodies)) activation and proinflammatory responses when stimulated by their ligands.
GRF1 is expressed in new neurons when GRF1 loss begins to effect neuronal function, promoting late stages of adult neurogenesis. GRF1 is an age-dependent regulator of adult hippocampal neurogenesis and the ability to distinguish closely related contexts.
Data indicate that contextual discrimination involves term potentiation (LTP (show SCP2 Antibodies)) promoted by calcium-permeable AMPA (show GRIA3 Antibodies)-type glutamate (show GRIN1 Antibodies) receptors, RAS-GRF1 (show RASGRF1 Antibodies) and p38 MAP kinase (show MAPK14 Antibodies).
The cellular RacGAP activity of p190RhoGAP requires an intact polybasic region adjacent to the GAP domain whereas the RhoGAP (show ARHGAP1 Antibodies) activity is inhibited by the same domain.
report association of APOE (show APOE Antibodies) and TOMM40 (show TOMM40 Antibodies) with behavioural variant frontotemporal dementia, and ARHGAP35 and SERPINA1 (show SERPINA1 Antibodies) with progressive non-fluent aphasia.
interaction involves the first FF motif of p190A and the winged helix/PCI (show SERPINA5 Antibodies) domain of eIF3A (show EIF6 Antibodies), is enhanced by serum stimulation and reduced by phosphatase treatment
these data demonstrate that a complex of p190RhoGAP-A and anillin (show ANLN Antibodies) modulates RhoA (show RHOA Antibodies)-GTP (show AK3 Antibodies) levels in the cytokinetic furrow to ensure progression of cytokinesis.
These results place Blk (show BLK Antibodies) upstream of the p190RhoGAP-RhoA (show RHOA Antibodies) pathway in Galpha13 (show GNA13 Antibodies)-activated cells, overall representing an opposing signaling module during CXCL12 (show CXCL12 Antibodies)-triggered invasion.
ARHGAP35 rs1052667 polymorphism was an independent prognostic factor influencing the survival of osteosarcoma.
GRF-1 expression may modify osteosarcoma prognosis and may be a potential tumor therapeutic target.
A ubiquitous binding partner of p190RhoGAP, p120RasGAP (RasGAP (show RASA1 Antibodies)), is expressed in much lower levels in DKO4 cells compared to DLD1, and this expression is regulated by KRAS.
Overexpression of p190 (show CNTNAP1 Antibodies) mRNA associated with lung adenocarcinoma.
These data suggest that the interaction of human papillomavirus E7 with p190 dysregulates this GTPase activating protein and alters the actin cytoskeleton.
RhoA (show RHOA Antibodies) is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis.
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.
glucocorticoid receptor DNA binding factor 1
, rho GTPase-activating protein 35
, P190 RhoGAP
, glucocorticoid receptor DNA-binding factor 1
, GRF beta
, Ras guanine release factor beta
, guanine nucleotide releasing factor 1
, guanine nucleotide-releasing protein
, ras-specific guanine nucleotide-releasing factor 1
, ras-specific nucleotide exchange factor CDC25
, glucocorticoid receptor repression factor 1
, rho GAP p190A
, GAP-associated protein p190