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Data show that hnf1ba generates a permissive domain for Wnt (show WNT2 Antibodies) signaling activity in the foregut endoderm
Knockdown of pk1a led to decreased expression of vhnf1 (show HNF1B Antibodies), a homeodomain gene previously shown to be involved in biliary development and in kidney cyst formation; forced expression of vhnf1 (show HNF1B Antibodies) mRNA led to rescue of the pk1a morphant phenotype
Data show that vhnf1 (show HNF1B Antibodies) functions in two ways to subdivide the zebrafish caudal (show CAD Antibodies) hindbrain domain (r4-r7) into individual rhombomeres.
Zebrafish tcf2 (show HNF1B Antibodies) gene, composed of 9 exons, was mapped to linkage group LG15.
vhnf1 (show HNF1B Antibodies) acts largely independently of val to repress the rhombomere 4 'hox (show MSH2 Antibodies) code' posterior to the rhombomere 4-5 boundary
Vhnf1 (show HNF1B Antibodies) expression within the posterior neural tube (up to r5) promotes posterior and dorsal fates in the otic vesicle, at the expense of anterior and ventral fates.
investigated the signaling pathways that regulate vhnf1 (show HNF1B Antibodies) expression during pancreas development
Data show that zebrafish mutants for Tcf2 (show HNF1B Antibodies) fail to specify a single lumen in their gut (show GUSB Antibodies) tube and instead develop multiple lumens, and show that Tcf2 (show HNF1B Antibodies) controls single lumen formation by regulating claudin15 and Na+/K+-ATPase (show ATP1A1 Antibodies) expression.
vHNF1 (show HNF1B Antibodies) plays crucial role at the earliest steps of liver induction: the acquisition of endoderm competence and the hepatic specification.
It was concluded that hnf1b(hi2169) is hypomorphic to hnf1b(hi1843) and that, while hnf1b is required for r5/r6 gene expression in the hindbrain, r5/r6 gene expression can be experimentally induced independently of hnf1b anterior to the hindbrain.
Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain.
, HNF1 homeobox b
, hepatocyte nuclear factor 1-beta
, hepatocyte nuclear factor 1-beta-2
, hepatocyte nuclear factor 1-beta-A
, transcription factor 2, hepatic
, variant hepatic nuclear factor 1