HNF1B antibody (N-Term)

Catalog No. ABIN2777700

Product Details anti-HNF1B Antibody

Target: HNF1B (HNF1 Homeobox B (HNF1B))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Cow, Horse, Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HNF1B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NFGVKLETLP LSPGSGAEPD TKPVFHTLTN GHAKGRLSGD EGSEDGDDYD

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rat: 92%, Zebrafish: 91%

Characteristics: This is a rabbit polyclonal antibody against HNF1B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HNF1B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 557 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HNF1B antibody (ABIN2777700)

Hakonarson, Qu, Bradfield, Marchand, Kim, Glessner, Grabs, Casalunovo, Taback, Frackelton, Eckert, Annaiah, Lawson, Otieno, Santa, Shaner, Smith, Onyiah, Skraban, Chiavacci, Robinson, Stanley, Kirsch et al.: "A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. ..." in: Diabetes, Vol. 57, Issue 4, pp. 1143-6, (2008) (PubMed).

Target Details for HNF1B

Target: HNF1B (HNF1 Homeobox B (HNF1B))

Alternative Name: HNF1B (HNF1B Products)

Synonyms: FJHN antibody, HNF-1B antibody, HNF1beta antibody, HNF2 antibody, HPC11 antibody, LF-B3 antibody, LFB3 antibody, MODY5 antibody, TCF-2 antibody, TCF2 antibody, VHNF1 antibody, HNF-1b antibody, HNF1B antibody, AI385728 antibody, AI987804 antibody, HNF-1Beta antibody, Hnf1beta antibody, Tcf-2 antibody, Tcf2 antibody, vHNF1 antibody, vHNF-1 antibody, chunp6877 antibody, hnf1b antibody, mst antibody, tcf2 antibody, vhnf1 antibody, lfb3 antibody, hnf-1beta antibody, hnf1-beta antibody, hnf1beta antibody, HNF1g antibody, wu:fc23f06 antibody, HNF1 homeobox B antibody, HNF1 homeobox Ba antibody, HNF1 homeobox B S homeolog antibody, HNF1 homeobox B L homeolog antibody, HNF1 homeobox Bb antibody, HNF1B antibody, Hnf1b antibody, hnf1ba antibody, hnf1b.S antibody, hnf1b.L antibody, hnf1bb antibody

Background: HNF1B is a member of the transcription factor superfamily. It forms heterodimers with another member of this transcription factor family, HNF1A. Multiple alternatively spliced transcript variants have been described, however the biological validity all of these variants needs to be determined.This gene encodes a member of the transcription factor superfamily. The encoded protein forms heterodimers with another member of this transcription factor family, HNF1A. Multiple alternatively spliced transcript variants have been described, however the biological validity all of these variants needs to be determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-473 DC340648.1 1-473 474-1994 BC017714.1 441-1961 1995-2544 AC091199.6 29528-30077 2545-2842 AI797324.1 1-298 c
Alias Symbols: FJHN, HNF1beta, HNF2, LFB3, MODY5, TCF2, VHNF1, HPC11, LF-B3
Protein Interaction Partner: HIST1H3A, PCBD1, CREBBP, HNF1A, ATF1, CREB1,
Protein Size: 557

Molecular Weight: 61 kDa

Gene ID: 6928

NCBI Accession: NM_000458, NP_000449

UniProt: P35680

Pathways: Hormone Transport, Stem Cell Maintenance, Tube Formation