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Browse our anti-OPA1 (OPA1) Antibodies

Full name:
anti-Optic Atrophy 1 (Autosomal Dominant) Antibodies (OPA1)
On www.antibodies-online.com are 63 Optic Atrophy 1 (Autosomal Dominant) (OPA1) Antibodies from 14 different suppliers available. Additionally we are shipping OPA1 Proteins (9) and many more products for this protein. A total of 75 OPA1 products are currently listed.
Synonyms:
1200011N24Rik, AI225888, AI847218, fk62d06, largeG, lilr3, MGM1, mKIAA0567, NPG, NTG, wu:fb77a10, wu:fk62d06, zgc:92092

Most Popular Reactivities for anti-OPA1 (OPA1) Antibodies

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anti-Mouse (Murine) OPA1 Antibodies:

anti-Rat (Rattus) OPA1 Antibodies:

anti-Human OPA1 Antibodies:

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Top referenced anti-OPA1 Antibodies

  1. Chicken Polyclonal OPA1 Primary Antibody for IHC, IHC (p) - ABIN258401 : Dai, Hsieh, Liu, Chen, Beyer, Chin, MacCoss, Rabinovitch: Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress. in Cardiovascular research 2011 (PubMed)
    Show all 14 references for ABIN258401

  2. Chicken Monoclonal OPA1 Primary Antibody for IF, WB - ABIN968891 : Alexander, Votruba, Pesch, Thiselton, Mayer, Moore, Rodriguez, Kellner, Leo-Kottler, Auburger, Bhattacharya, Wissinger: OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. in Nature genetics 2000 (PubMed)
    Show all 3 references for ABIN968891

  3. Chinese Hamster Monoclonal OPA1 Primary Antibody for ICC, IF - ABIN4341456 : Montaigne, Marechal, Coisne, Debry, Modine, Fayad, Potelle, El Arid, Mouton, Sebti, Duez, Preau, Remy-Jouet, Zerimech, Koussa, Richard, Neviere, Edme, Lefebvre, Staels: Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients. in Circulation 2014 (PubMed)
    Show all 2 references for ABIN4341456

  4. Human Polyclonal OPA1 Primary Antibody for ELISA - ABIN562069 : Yarosh, Monserrate, Tong, Tse, Le, Nguyen, Brachmann, Wallace, Huang: The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment. in PLoS genetics 2008 (PubMed)

  5. Human Polyclonal OPA1 Primary Antibody for IF (p), IHC (p) - ABIN1387244 : Ku, Ji, Zhang, Li, Sang: PM2.5, SO2 and NO2 co-exposure impairs neurobehavior and induces mitochondrial injuries in the mouse brain. in Chemosphere 2016 (PubMed)

More Antibodies against OPA1 Interaction Partners

Mouse (Murine) Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. OPA1 (show MED12 Antibodies) modulates cristae morphology but is dispensable for cristae junction formation. Endogenous OPA1 (show MED12 Antibodies) and MIC60 show a physical interaction.

  2. Opa1 (show MED12 Antibodies) deficiency was associated with increased sensitivity to Ischemia-Reperfusion Injuries, imbalance in dynamic mitochondrial Ca2 (show CA2 Antibodies)+ uptake, and subsequent increase in NCX (show SLC8A1 Antibodies) activity.

  3. Whereas Parkin (show PARK2 Antibodies) has been reported to positively regulate the expression of OPA1 (show MED12 Antibodies) through NEMO (show IKBKG Antibodies), herein we found that PARK2 (show PARK2 Antibodies) overexpression did not modify the expression of OPA1 (show MED12 Antibodies).

  4. stress-induced OMA1 (show OMA1 Antibodies) activation and guanosine triphosphatase OPA1 (show MED12 Antibodies) cleavage limit mitochondrial fusion and promote neuronal death

  5. Data suggest that in a mouse model of neonatal hypoxic-ischemic brain injury, the expression of mitochondrial shaping proteins, such as OPA1 (show MED12 Antibodies) and Yme1L (show YME1L1 Antibodies), are altered; in vitro and in vivo, OPA1 (show MED12 Antibodies) is cleaved to shorter forms and Yme1L (show YME1L1 Antibodies) expression is reduced.

  6. results indicate that the OPA1 (show MED12 Antibodies)-dependent cristae remodeling pathway is a fundamental, targetable determinant of tissue damage in vivo.

  7. cristae shape amelioration by controlled Opa1 (show MED12 Antibodies) overexpression improves two mouse models of mitochondrial disease.

  8. unprocessed OPA1 (show MED12 Antibodies) is sufficient to maintain heart function, OMA1 (show OMA1 Antibodies) is a critical regulator of cardiomyocyte survival, and mitochondrial morphology and cardiac metabolism are intimately linked.

  9. Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: OPA1 (show MED12 Antibodies), Drp1 (dynamin 1-like protein (show DNM1L Antibodies)), and Mfn1 (show MFN1 Antibodies)/2 (mitofusin 1 (show MFN1 Antibodies) and 2). [REVIEW]

  10. Photoresponsive RGCs are protected against cell death due to the Opa1 (show MED12 Antibodies) mutation, but not by melanopsin (show OPN4 Antibodies) expression itself.

Human Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. The gene signature of OPA1, CTSA (show CTSA Antibodies), NDUFA1 (show NDUFA1 Antibodies), STK10 (show STK10 Antibodies) and PRDX1 (show PRDX1 Antibodies) was able to identify patients post-implant with a sensitivity of 91% and a specificity of 86% in discrimination between post-implant group and healthy controls.

  2. The architecture of dendritic arborization in patients with OPA1 mutations is not known, but our data support the idea that loss of dendritic arborization may be involved in the pathogenesis of DOA rather than just population loss.

  3. OPA1 disclosed a de novo heterozygous deletion c.2012+4_2012+7delAGTA resulting in exon 18 and 19 skipping, which was not detected in healthy family members.

  4. This study demonstrated increased mitophagy and excessive mitochondrial fragmentation in primary human cultures associated with DOA plus due to biallelic OPA1 mutations.

  5. The present study identified novel compound heterozygous OPA1 mutations in a patient with recessive optic atrophy, sensorimotor neuropathy and congenital cataracts, indicating an expansion of the clinical spectrum of pathologies associated with OPA1 mutations.

  6. Optic atrophy type 1, caused by mutations in the OPA1 gene is believed to be the most common hereditary optic neuropathy, and most patients inherit a mutation from an affected parent. In this study we used whole-exome sequencing to investigate the genetic aetiology in a patient affected with isolated optic atrophy. Exome results identified a novel de novo OPA1 mutation.

  7. Findings show a new mode of regulation of the mitochondrial fusion proteins, Mfns degradation or OPA1 processing, in response to mitochondrial morphology.

  8. Loss of OPA1 protein function by pathogenic OPA1 gene mutation induces increased mitochondrial fragmentation that promotes instability of the mitochondrial respiratory chain complexes.

  9. Two heterozygous mutations, p.T414P (c.1240A>C) and p.T540P (c.1618A>C), located in the GTPase (show RACGAP1 Antibodies) and middle domains of OPA1, respectively, were identified in two patients.These two different conformational changes might result in decreased GTPase (show RACGAP1 Antibodies) activities that trigger autosomal dominant optic atrophy associated with auditory neuropathy spectrum disorder

  10. A causal link between a pathogenic homozygous OPA1 mutation and hypertrophic cardiomyopathy with optic atrophy was established.It emphasise the vital role played by OPA1 in mitochondrial biogenesis and mtDNA maintenance.

Zebrafish Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. Opa1 is required for proper mitochondrial metabolism in early development

OPA1 Antigen Profile

Antigen Summary

This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with OPA1

  • optic atrophy 1 (Opa1) antibody
  • optic atrophy 1 (autosomal dominant) (OPA1) antibody
  • optic atrophy 1 (human) (opa1) antibody
  • 1200011N24Rik antibody
  • AI225888 antibody
  • AI847218 antibody
  • fk62d06 antibody
  • largeG antibody
  • lilr3 antibody
  • MGM1 antibody
  • mKIAA0567 antibody
  • NPG antibody
  • NTG antibody
  • wu:fb77a10 antibody
  • wu:fk62d06 antibody
  • zgc:92092 antibody

Protein level used designations for OPA1

dynamin-like 120 kDa protein, mitochondrial , large GTP-binding protein , largeG , optic atrophy 1 homolog , optic atrophy protein 1 homolog , RN protein , optic atrophy 1 (autosomal dominant) , optic atrophy 1-like protein , dynamin-like guanosine triphosphatase , mitochondrial dynamin-like GTPase , optic atrophy protein 1

GENE ID SPECIES
74143 Mus musculus
171116 Rattus norvegicus
4976 Homo sapiens
424900 Gallus gallus
477129 Canis lupus familiaris
524142 Bos taurus
100172619 Pongo abelii
492332 Danio rerio
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