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the OVOL2 promoter variant c.-307T>C was herein identified in the original family that established the posterior polymorphous corneal dystrophy 1 locus.
OVOL2 maintains the transcriptional program of human corneal epithelium cells.
Ovol2 can suppress migration and invasion ability of A549 cells, and prevent EMT (show ITK Proteins) by inhibition of Twist1 (show TWIST1 Proteins) transcription directly.
congenital hereditary endothelial dystrophy 1 (CHED1) and CHED2 (show SLC4A11 Proteins) loci on chromosome 20 and the collagen, type VIII (show COX8A Proteins), alpha-2 (COL8A2 (show COL8a2 Proteins)) gene were excluded by linkage and haplotype analyses.
that the OVOL1 (show OVOL1 Proteins)-OVOL2 axis may actively contribute to cell differentiation and proliferation in the hair bulb
OVOL2 is a colorectal tumor suppressor (show DCC Proteins) that blocks WNT (show WNT2 Proteins) signaling by facilitating the recruitment of histone deacetylase 1 (show HDAC1 Proteins) to the TCF4 (show TCF4 Proteins)-beta-catenin (show CTNNB1 Proteins) complex.
data demonstrate that all four mutated OVOL2 promoters exhibited more transcriptional activity than the corresponding wild-type promoter
Molecular phylogeny of OVOL1 (show OVOL1 Proteins), OVOL2 and OVOL3 (show OVOL3 Proteins) genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions in humans and other species
Ovol2 directly represses two critical downstream targets, c-Myc (show MYC Proteins) and Notch1 (show NOTCH1 Proteins), thereby suppressing keratinocyte transient proliferation and terminal differentiation, respectively
Association of a chromosomal rearrangement event with mouse posterior polymorphous corneal dystrophy and alterations in Csrp2bp (show CSRP2BP Proteins), Dzank1 (show DZANK1 Proteins), and Ovol2 gene expression have been reported.
a Grhl2 (show GRHL2 Proteins)/Ovol2 network controls Cldn4 (show CLDN4 Proteins) and Rab25 (show RAB25 Proteins) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
We show that ER71 (show ETV2 Proteins) directly interacts with OVOL2 and that such interaction is critical for FLK1 (show KDR Proteins)(+) cell generation and their differentiation into downstream cell lineages.
Deletion of Ovol2 blocks mammary ductal morphogenesis, depletes stem and progenitor cell reservoirs, and leads epithelial cells to undergo EMT (show ITK Proteins) .
Ovol2 acts downstream of the BMP pathway in the cell fate decision between neuroectoderm and mesendoderm to ensure proper germ layer development.
Ovol2/MOVO may play an important role in the XY body during spermatogenesis, possibly in the processes of XY body formation and meiotic sex chromosome inactivation.
Ovol2 transcription was dramatically reduced in testes from blind-sterile mice, suggesting that Ovol2 is expressed in male germ cells
Ovol2 is a key regulator of neural development and reveal a previously unexplored role for Ovo genes in mammalian embryogenesis.
Expression of Ovol2 was up-regulated in Ovol1 (show OVOL1 Proteins)-deficient epidermis; Ovol1 (show OVOL1 Proteins) represses the activity of Ovol2 promoter in a DNA binding-dependent manner identifying Ovol2 as a downstream target of Ovol1 (show OVOL1 Proteins).
DNA-binding protein that binds to the 5'-GGGGGG-3' core sequence. Probably acts as a transcription regulator.
ovo-like 2 (Drosophila)
, ovo-like 2
, transcription factor Ovo-like 2
, zinc finger protein 339
, MOVO-B zinc finger protein
, MOVO-C zinc finger protein
, OVO homolog-like 2
, zinc finger OVO2
, zinc finger protein mOVO