Browse our Oxidative-Stress Responsive 1 Proteins (OXSR1)

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Synonyms:
2210022N24Rik, 2810422B09Rik, AI462649, AW209236, mKIAA1101, Osr1, OXSR1, zgc:55494, zgc:77321
list all proteins Gene Name GeneID UniProt
OXSR1 9943 O95747
Rat OXSR1 OXSR1 316064  
OXSR1 108737 Q6P9R2

Oxidative-Stress Responsive 1 Proteins (OXSR1) by Origin

More Proteins for Oxidative-Stress Responsive 1 Interaction Partners

Human Oxidative-Stress Responsive 1 (OXSR1) interaction partners

  1. the WNK-regulated SPAK (show STK39 Proteins)/OSR1 kinases directly phosphorylate the N[K]CCs (show CCS Proteins) and KCCs, promoting their stimulation and inhibition respectively.

  2. SPAK (show STK39 Proteins) and OSR1, which are often coexpressed in cells, can form functional heterodimers.

  3. Data show that intracellular association between WNK1 (show WNK1 Proteins) and oxidative stress-responsive 1 (OSR1) is required for stimulation of OSR1 and Na(+), K(+), Cl(-)-Cotransporter NKCC1 (show SLC12A2 Proteins) and NKCC2 (show SLC12A1 Proteins) activities by osmotic stress.

  4. OXSR1 and WNK3 transcripts were substantially overexpressed in subjects with schizophrenia relative to comparison subjects.

  5. isolation and characterization of OSR1 (oxidative stress-responsive 1), one of two human Fray homologs. OSR1 is a 58-kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines

  6. WNK1 (show WNK1 Proteins) and SPAK (show STK39 Proteins)/OSR1 mediate the hypotonic stress signaling pathway to cation-chloride-coupled cotransporters

  7. OXSR1 kinase is shown to interact with the three RELT (show RELT Proteins) family members RELT (show RELT Proteins), RELL1, and RELL2 by in vitro co-immunoprecipitation; additionally, OXSR1 phosphorylates RELT (show RELT Proteins) family members in an in vitro kinase assay.

  8. data establish that the CCT (show FLVCR2 Proteins) domain functions as a multipurpose docking site, enabling SPAK (show STK39 Proteins)/OSR1 to interact with substrates (NKCC1 (show SLC12A2 Proteins)) and activators (WNK1 (show WNK1 Proteins)/WNK4 (show WNK4 Proteins))

  9. OSR1 and sterile20-related, proline-, alanine-rich kinase are likely links between WNK lysine deficient protein kinase 1 (show WNK1 Proteins) and solute carrier (show SERTAD2 Proteins) family 12 in a pathway that contributes to volume regulation and blood pressure homeostasis in mammals

  10. These results provide the first molecular insight into the mechanism by which the SPAK (show STK39 Proteins) and OSR1 kinases specifically recognize their upstream activators and downstream substrates.

Mouse (Murine) Oxidative-Stress Responsive 1 (OXSR1) interaction partners

  1. increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase

  2. OSR1 (show OSR1 Proteins) is expressed in intestine and partial WNK insensitivity of OSR1 (show OSR1 Proteins) increases intestinal Na( )/H( ) exchanger activity and colonic epithelium Na( ) channel activity

  3. Data indicate that SPAK (show STK39 Proteins) and OSR1 (show OSR1 Proteins) function interdependently in the distal convoluted tubule (DCT (show DCT Proteins)) to positively regulate thiazide-sensitive sodium-chloride cotransporter (show SLC12A3 Proteins), NCC (show SLC12A3 Proteins).

  4. Partial OSR1 (show OSR1 Proteins) deficiency influences Na(+)/H(+) exchanger activity, ROS (show ROS1 Proteins) formation, and migration of dendritic cells.

  5. Results clearly establish that PHAII caused by the WNK4 (show WNK4 Proteins) D561A mutation is dependent on the activation of the WNK-OSR1 (show OSR1 Proteins)/SPAK (show STK39 Proteins)-NCC (show SLC12A3 Proteins) cascade.

  6. Two Ste20-like (show STK25 Proteins) kinases that bind and phosphorylate NKCC1 (show SLC12A2 Proteins): Ste20 (show STK24 Proteins)-related proline-alanine-rich kinase (SPAK (show STK39 Proteins)) and oxidative-stress response 1 (OSR1 (show OSR1 Proteins)), were identified.

  7. In the kidneys, NKCC2 (show SLC12A1 Proteins) but not NCC (show SLC12A3 Proteins) is the main target of OSR1 (show OSR1 Proteins) and the reduced p-NKCC2 (show SLC12A1 Proteins) in KSP-OSR1 (show OSR1 Proteins)(-/-) mice may lead to a Bartter-like syndrome.

  8. phosphorylation states of NCC (show SLC12A3 Proteins) and OSR1 (show OSR1 Proteins)/SPAK (show STK39 Proteins) (Gene: Oxsr1, GeneID: 108737) were increased by low-salt diets and decreased by high-salt diets

  9. OSR1 (show OSR1 Proteins), a kinase closely related to SPAK (show STK39 Proteins), exhibited similar kinase properties and similar functional activation of NKCC1 (show SLC12A2 Proteins) when coexpressed with WNK4 (show WNK4 Proteins).

  10. review: NCC (show SLC12A3 Proteins) in the distal convoluted tubule plays a critical role in NaCl and, indirectly, in K+ homeostasis; regulation by SPAK (show STK39 Proteins)/OSR1 (show OSR1 Proteins) kinases and WNKs.

Pig (Porcine) Oxidative-Stress Responsive 1 (OXSR1) interaction partners

  1. The gene shows 92.8% nucleotide identity and 95.5% amino acid identity with human OSR1 (show OSR1 Proteins).

Oxidative-Stress Responsive 1 (OXSR1) Protein Profile

Protein Summary

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.

Alternative names and synonyms associated with Oxidative-Stress Responsive 1 (OXSR1)

  • oxidative-stress responsive 1 (OXSR1)
  • oxidative-stress responsive 1b (oxsr1b)
  • serine/threonine-protein kinase OSR1 (CpipJ_CPIJ015177)
  • serine/threonine-protein kinase OSR1 (Tsp_00299)
  • odd-skipped related 1 (Drosophila) (OSR1)
  • oxidative stress responsive 1 (OXSR1)
  • oxidative-stress responsive 1 (Oxsr1)
  • 2210022N24Rik protein
  • 2810422B09Rik protein
  • AI462649 protein
  • AW209236 protein
  • mKIAA1101 protein
  • Osr1 protein
  • OXSR1 protein
  • zgc:55494 protein
  • zgc:77321 protein

Protein level used designations for OXSR1

serine/threonine-protein kinase OSR1 , oxidative-stress responsive 1 , protein odd-skipped-related 1 , oxidative stress-responsive 1 protein

GENE ID SPECIES
100050017 Equus caballus
394150 Danio rerio
6048779 Culex quinquefasciatus
10901611 Trichinella spiralis
539430 Bos taurus
9943 Homo sapiens
607809 Canis lupus familiaris
316064 Rattus norvegicus
108737 Mus musculus
397618 Sus scrofa
100174028 Pongo abelii
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