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Rat (Rattus) PODXL ELISA Kit for Sandwich ELISA - ABIN578102
Guo, Zhang, Wang, Ren, Zhou, Ma, Wu, Qin: Effects of FoxO1 on podocyte injury in diabetic rats. in Biochemical and biophysical research communications 2015
PODXL enhances motility and invasiveness through an increase in gelsolin-actin interactions in cell protrusions.
Results identify an anti-metastatic miRNA, miR (show MLXIP ELISA Kits)-5100, that decreases the metastatic ability of pancreatic cancer partially by suppressing expression of PODXL.
Results indicate that urinary podocalyxin is not only an early marker but also a treatment target for diabetic nephropathy (DN).
Obese subjects showed evidence of renal alteration through the detection of a higher number of urinary podocalyxin positive cells.
Data show that both mucin16 (MUC16 (show MUC16 ELISA Kits)) and podocalyxin (PODXL)-E-selectin (show SELE ELISA Kits)-mediated interactions are mechanically stronger than like L-selectin (show SELL ELISA Kits) interactions at the single-molecule level.
In gastric cancer, PODXL expression by the polyclonal antibody HPA2110 is an independent marker of poor prognosis.
PCX (show PC ELISA Kits) promotes cisplatin chemoresistance in osteosarcoma cells through a PI3Kdependent mechanism.
EZR (show EZR ELISA Kits), CLIC5 (show CLIC5 ELISA Kits) and PODXL are overexpressed in hepatocellular carcinoma and may have a role in cell migration and invasiveness
PODXL up-regulates the expression level of Bmi1 (show BMI1 ELISA Kits) in OTSCC cells.
podocalyxin to be an independent factor for poor prognosis in PDAC. To our knowledge, this is the first such report of its prognostic value.
Podxl-KO led to heightened G-CSF (show CSF3 ELISA Kits) activation of Rap1a (show RAP1A ELISA Kits)(GTP (show AK3 ELISA Kits)), and Rap1a (show RAP1A ELISA Kits)(GTP (show AK3 ELISA Kits)) inhibition attenuated Podxl-KO neutrophil migration. Studies have revealed novel roles for Podxl as an important modulator of neutrophil and monocyte formation and of Rap1a (show RAP1A ELISA Kits) activation during stress hematopoiesis.
Podxl-overexpression in neural stem/progenitor cells leads to an up-regulation of Annexin A2 (show ANXA2 ELISA Kits).
when endogenous podocalyxin was removed from highly metastatic 4T1 mammary tumor cells there was a decrease in collective invasion . Podocalyxin is a tumor cell-intrinsic regulator of experimental collective tumor cell invasion and tumor budding.
Podocalyxin has a role in glioblastoma multiforme cell invasion and proliferation via beta-catenin (show CTNNB1 ELISA Kits) signaling
Loss of podocalyxin from the lung vasculature results in changes to the lung structure and function including increased lung volume when inflated under constant pressure (25 cm H2O) and changes to the matrix composition.
CTGF (show CTGF ELISA Kits) is an important mediator of high glucose-induced podocyte damage and decreases the protein level of podocalyxin by the ERK1/2 (show MAPK1/3 ELISA Kits) pathway.
platelet Podxl is involved in the control of hemostasis acting as a platelet co-stimulator, likely due to its pro-adhesive properties
Full-length recombinant murine podocalyxin recruits NHERF-1 (show SLC9A3R1 ELISA Kits) to the apical domain. Ectopic expression in human & canine epithelial cells leads to microvilli formation on an apical domain extending laterally to the junctional complexes.
Podocalyxin plays multiple roles in neural development
PODXL may act as a costimulator of agonists in the activation of platelets and formation of a stable thrombus.
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.
, podocalyxin-like protein 1-like
, GCTM-2 antigen
, podocalyxin-like protein 1
, PC-like protein 1
, Podocalyxin-like protein 1