Browse our Transglutaminase 2 Proteins (TGM2)

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Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) Proteins (TGM2)
On are 29 Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2) Proteins from 11 different suppliers available. Additionally we are shipping Transglutaminase 2 Antibodies (301) and Transglutaminase 2 Kits (40) and many more products for this protein. A total of 385 Transglutaminase 2 products are currently listed.
fc12b04, G-ALPHA-h, GNAH, G[a]h, TG2, TGase2, TgaseII, TGC, TGL2, TGM2, tTG, tTGas, wu:fc12b04, zgc:101081, zgc:136700
list all proteins Gene Name GeneID UniProt
TGM2 7052 P21980
Rat TGM2 TGM2 56083  
TGM2 21817 P21981

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Transglutaminase 2 Proteins (TGM2) by Origin

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Top referenced Transglutaminase 2 Proteins

  1. Human Transglutaminase 2 Protein expressed in - ABIN1047979 : Faye, Inforzato, Bignon, Hartmann, Muller, Ballut, Olsen, Day, Ricard-Blum: Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells. in The Biochemical journal 2010 (PubMed)

  2. Human Transglutaminase 2 Protein expressed in Wheat germ - ABIN1322636 : Velez V, Romano, McKown, Green, Zhang, Raab, Ryan, Hutnik, Frierson, Laurie: Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity. in Investigative ophthalmology & visual science 2013 (PubMed)

More Proteins for Transglutaminase 2 Interaction Partners

Human Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2) interaction partners

  1. GTP binding (show RND2 Proteins), but not transamidase activity, is required for TG2-dependent cancer stem cell invasion, migration and tumour formation. However, transamidase site-specific inhibitors reduce cancer stem cell survival.

  2. these findings ascribe a novel function for ALDH1A3 (show ALDH1A3 Proteins) in an aggressive glioma stem cells phenotype via the up-regulation of tissue transglutaminase

  3. Data show that carboxyl-terminus of Hsp70-interacting protein (show HSPBP1 Proteins) (CHIP) promotes polyubiquitination of transglutaminase 2 (TG2) and its subsequent proteasomal degradation.

  4. No clear evidence for an association of tTGA or EMA (show ETFA Proteins) seropositivity with incident coronary heart disease outcomes, suggesting that tTG autoimmunity is unlikely to be the biological link between coeliac disease and CHD (show CHDH Proteins).

  5. the TG2 enzymatic activity was negligibly affected by bexarotene treatment. It is important to control TG2 overexpression since its upregulation is correlated with tumor transformation and drug resistance. Bexarotene also showed in vivo tumoricidal effects in a GBM xenograft mouse model. Therefore, we suggest bexarotene as a more beneficial differentiation agent than ATRA for GBM.

  6. Thus it can be concluded that human transglutaminases differ in harboring damaging variants and TGM2 is under purifying selection suggesting that it may have so far not revealed physiological functions.

  7. mechanical load-induced TGM2 expression and enzyme activity is involved in the progression of the calcification of ligamentum flavum.

  8. interconnected network of TG2/NF-kappaB (show NFKB1 Proteins) and IL6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling with autophagy regulation in MCL (show FH Proteins) cells.

  9. TGM2 expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.

  10. The serum level of TG2 is increased in patients with chronic spontaneous urticarial, and TG2 is expressed in mast cells in the lesional skin of these patients.

Cow (Bovine) Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2) interaction partners

  1. TG2 contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT (show AKT1 Proteins) signaling, likely via its serotonylation.

  2. An important role for TG2, mediated by intracellular calcium fluxes and HIF1A (show HIF1A Proteins), in hypoxia-induced pulmonary artery smooth muscle cells proliferation.

  3. externalized GTP (show AK3 Proteins)-bound TG2 serves as a molecular switch for differentiation of chondrocytes to a hypertrophic, calcifying phenotype in a manner that does not require either TG2 transamidation activity or fibronectin (show FN1 Proteins) binding

Mouse (Murine) Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2) interaction partners

  1. findings support the potential pathophysiological relevance of TRX (show TXN Proteins) in celiac disease and establish the Cys (show DNAJC5 Proteins)(370)-Cys (show DNAJC5 Proteins)(371) disulfide bond of TG2 as one of clearest examples of an allosteric disulfide bond in mammals.

  2. TG2 controls the formation of VEGF165-heparan sulfate proteoglycan complexes

  3. TG2 is a novel inhibitor of adipogenesis.

  4. LPS (show TLR4 Proteins)-induced TG2 was involved in the mechanism of pinocytosis and phagocytosis in microglia.

  5. Inhibition of tissue transglutaminase resulted in a reduced rate of compaction compared to controls during early remodeling (up to 2 days). In contrast, inhibition of lysyl oxidase (show LOX Proteins) did not alter the early compaction.

  6. TG2-deficient mice exhibited hyper inflammatory responses after being challenged with monosodium urate crystals.

  7. Data presented in this study show that TG2 plays a key role in cellular dynamics and consequently influences the energetic metabolism.

  8. TG2 functions as a critical signal for allergic lung responses.

  9. TG2 ablation had no effect on either motor or cognitive deficits, or on the weight loss.

  10. TG2 is an important mediator of endothelial cell inflammation and lung PMN (show TBCE Proteins) sequestration associated with intravascular coagulation and sepsis

Transglutaminase 2 (TGM2) Protein Profile

Protein Summary

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Transglutaminase 2 (TGM2)

  • transglutaminase 2 (TGM2)
  • transglutaminase 2, C polypeptide A (tgm2a)
  • transglutaminase 2, C polypeptide (Tgm2)
  • transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) (TGM2)
  • transglutaminase 2b (tgm2b)
  • transglutaminase 2 (LOC100352148)
  • fc12b04 protein
  • G-ALPHA-h protein
  • GNAH protein
  • G[a]h protein
  • TG2 protein
  • TGase2 protein
  • TgaseII protein
  • TGC protein
  • TGL2 protein
  • TGM2 protein
  • tTG protein
  • tTGas protein
  • wu:fc12b04 protein
  • zgc:101081 protein
  • zgc:136700 protein

Protein level used designations for TGM2

C polypeptide, protein-glutamine-gamma-glutamyltransferase , TG(C) , TGase C , TGase H , TGase-2 , TGase-H , protein-glutamine gamma-glutamyltransferase 2 , protein-glutamine-gamma-glutamyltransferase , tissue transglutaminase , transglutaminase C , transglutaminase H , transglutaminase-2 , TG2c , transglutaminase 2 , tissue-type transglutaminase , transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) , TGC , C polypeptide , TG C

7052 Homo sapiens
447909 Danio rerio
56083 Rattus norvegicus
469937 Pan troglodytes
281528 Bos taurus
323856 Danio rerio
396432 Gallus gallus
100127492 Sus scrofa
485867 Canis lupus familiaris
100352148 Oryctolagus cuniculus
21817 Mus musculus
100379228 Cavia porcellus
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