Transglutaminase 2 Protein (AA 2-687) (His tag)
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- Target See all Transglutaminase 2 (TGM2) Proteins
- Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-687
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Transglutaminase 2 protein is labelled with His tag.
- Purpose
- Human TGM2 Protein
- Sequence
- Ala2-Ala687
- Characteristics
- Recombinant Human TGM2 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Ala2-Ala687.
- Purity
- > 95 % as determined by Tris-Bis PAGE
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human TGM2, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-TGM2 Antibody, hFc Tag with the EC50 of 9.3ng/ml determined by ELISA. See testing image for detail.
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as 0.22μm filtered solution in 20 mM Tris, 500 mM NaCl, 10 % Glycerol ( pH 7.4).
- Storage
- -80 °C
- Storage Comment
- Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))
- Alternative Name
- TGM2 (TGM2 Products)
- Synonyms
- G-ALPHA-h Protein, GNAH Protein, TG2 Protein, TGC Protein, tgm2 Protein, zgc:101081 Protein, TgaseII Protein, TGM2 Protein, fc12b04 Protein, wu:fc12b04 Protein, zgc:136700 Protein, TGL2 Protein, G[a]h Protein, TGase2 Protein, tTG Protein, tTGas Protein, transglutaminase 2 Protein, transglutaminase 2, C polypeptide A Protein, transglutaminase 2b Protein, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) Protein, transglutaminase 2, C polypeptide Protein, TGM2 Protein, tgm2a Protein, Tgm2 Protein, tgm2b Protein
- Background
- Transglutaminase 2 (TGM2) is a member of the transglutaminase family, and it is reported to be associated with chemoresistance in various types of cancer. TGM2 was demonstrated to affect the chemosensitivity of osteosarcoma cells via regulation of the activation of mitogen-activated protein kinase and AKT serine/threonine kinase pathways.
- Molecular Weight
- 78.4 kDa same as Tris-Bis PAGE result.
- Pathways
- Tube Formation, Thromboxane A2 Receptor Signaling
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