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anti-Human TRIM71 Antibodies:
anti-Rat (Rattus) TRIM71 Antibodies:
anti-Mouse (Murine) TRIM71 Antibodies:
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Mouse (Murine) Polyclonal TRIM71 Primary Antibody for ELISA, WB - ABIN4331054
Lin, Hsieh, Kuo, Yu, Kuo, Lo, Lin, Yu, Li: Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. in Molecular biology and evolution 2007
Studies indicate most-studied TRIpartite Motif (TRIM (show TRAT1 Antibodies))-NHL (show RTEL1 Antibodies) proteins TRIM2 (show TRIM2 Antibodies), TRIM3 (show TRIM3 Antibodies), TRIM32 (show TRIM32 Antibodies) and TRIM71, and their mutations have been linked to diseases.
Consistent with the let-7 microRNA stimulatory role of TRIM71 via Lin28B (show LIN28B Antibodies) polyubiquitination.
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing.
Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation
Repression of human TRIM71 and the zebrafish lin-41 ortholog was abolished when predicted let-7 target sites were mutated. Regulation of TRIM71 expression by let-7 seems to have been evolutionarily conserved.
suggest that Trim71 keeps priming steps of differentiation in check, which do not pre-require a loss of the pluripotency network in ES cells
Two well-known E3 ubiquitin ligases, Trim25 (show TRIM25 Antibodies) (also called Efp (show TRIM25 Antibodies)) and Trim71 (also called Lin41), are validated as RNA-binding proteins, revealing a potential link between RNA biology and protein-modification pathways.
mLin41 acts as a temporal regulator to promote neural progenitor cell maintenance, not via the regulation of AGO2 (show EIF2C2 Antibodies) stability, but through FGF signaling.
Lin-41 is genetically and biochemically downstream of both the Shh (show SHH Antibodies) and Fgf signaling pathways and is expressed in three phases over developmental time and most notably is associated with the developing autopod.
lin-41 is temporally regulated by miRNAs in order to direct key developmental events such as limb formation.
May be involved in controlling the timing of organ formation during development (By similarity).
E3 ubiquitin-protein ligase TRIM71
, abnormal cell LINeage LIN-41
, homolog of C. elegans Lin-41
, protein lin-41 homolog
, tripartite motif-containing 71
, tripartite motif-containing protein 71
, B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41)
, Drosophila dappled/ vertebrate TRipartite Motif protein related
, lin-41 homolog