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Browse our anti-GSK3 beta (GSK3b) Antibodies

Full name:
anti-Glycogen Synthase Kinase 3 beta Antibodies (GSK3b)
On www.antibodies-online.com are 2 Glycogen Synthase Kinase 3 beta (GSK3b) Antibodies from 1 different suppliers available. A total of 2 GSK3 beta products are currently listed.
Synonyms:
7330414F15Rik, 8430431H08Rik, C86142, fk80d11, gsk-3, GSK-3beta, GSK-3[b], gsk3, gsk3-beta, GSK3beta, wu:fb68h05, wu:fk80d11, xgsk-3
list all antibodies Gene Name GeneID UniProt
GSK3b 56637 Q9WV60
GSK3b 84027 P18266
GSK3b 2932 P49841

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anti-Mouse (Murine) GSK3 beta Antibodies:

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Mouse (Murine) Glycogen Synthase Kinase 3 beta (GSK3b) interaction partners

  1. Voluntary exercise produces a lasting protective state in the hippocampus, maintained in hippocampal slices by a PI3K-dependent mechanism that precludes its functional disruption in the presence of Abeta (show APP Antibodies) by avoiding GSK3beta activation

  2. The GSK-3beta activity increased, and expression of beta-catenin (show CTNNB1 Antibodies) decreased significantly in the hippocampus of the chronic intermittent hypoxia exposed mice.

  3. GSK3b may up-regulate BK channels, an effect disrupted by lithium or additional expression of AKT (show AKT1 Antibodies) and possibly participating in the regulation of cell volume and excitability.

  4. Cadmium induces cell death on cholinergic neurons through blockade of M1 receptor, overexpression of AChE-S and GSK-3beta, down-regulation of AChE-R and increase in Abeta (show APP Antibodies) and total and phosphorylated tau protein levels.

  5. These results reveal a key role of the AKT (show AKT1 Antibodies)-GSK3beta-eIF2Bepsilon (show EIF2B5 Antibodies) signaling module in regulating axon regeneration in the adult mammalian central nervous system.

  6. The GSK3 activity in mouse testes and sperm were quantifiable by gel shift assay with low sample consumption and were significantly correlated with the expression levels of GSK3 and p-GSK3. We suggest that our assay can be used for reliable and rapid detection of GSK3 activity in cells and tissue extracts.

  7. The predominant AKT (show AKT1 Antibodies) isoform in the central nervous system, AKT3 (show AKT3 Antibodies), induces much more robust axon regeneration than AKT1 (show AKT1 Antibodies) and that activation of mTORC1 and inhibition of GSK3beta are two critical parallel pathways for AKT (show AKT1 Antibodies)-induced axon regeneration.

  8. The expression of PI3K-insensitive GSK3 stimulates the production of adiponectin (show ADIPOQ Antibodies) and protects from diet-induced metabolic syndrome.

  9. The upregulation of pGSK-3beta-Tyr (show TYR Antibodies)(216) was also found in the R6/2 transgenic mice hippocampus in vivo and linked to the increased vulnerability of primary hippocampal neurons in vitro.

  10. Findings reveal a novel regulatory pathway in which the REGgamma (show PSME3 Antibodies)-proteasome controls the steady-state level of GSK3beta protein.

Human Glycogen Synthase Kinase 3 beta (GSK3b) interaction partners

  1. Inhibition of p90 (show CANX Antibodies) ribosomal S6 kinase (show RPS6KB1 Antibodies) attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3beta and osteopontin (show SPP1 Antibodies).

  2. Data show that the elevated activities of PI3Ks, AKt (show AKT1 Antibodies) and GSK-3beta were effectively suppressed by exogenous carbon monoxide (CO), leading to the improvement of platelet function.

  3. GSK3b may up-regulate BK channels, an effect disrupted by lithium or additional expression of AKT (show AKT1 Antibodies) and possibly participating in the regulation of cell volume and excitability.

  4. These data suggest that GSK-3beta is involved in hypoxic adaptation of gastric cancer cells as an inhibitory upstream regulator of the HIF-1alpha/VEGF signaling pathway.

  5. GSK3beta plays a major role in maintenance of stemness of CD44 (show CD44 Antibodies)(high) /ALDH1 (show ALDH1A1 Antibodies)(high) HNSCC cells.

  6. These findings suggest that emodin inhibited the EMT (show ITK Antibodies) of EOC cells via ILK (show ILK Antibodies)/GSK-3beta/Slug (show SNAI2 Antibodies) signaling pathway

  7. Data show that heterogeneous nuclear ribonucleoprotein K (hnRNPK (show HNRNPK Antibodies)) stabilized of cellular FLICE-inhibitory protein (c-FLIP (show CFLAR Antibodies)) protein through inhibition of glycogen synthase kinase 3 beta (GSK3beta) Ser9 phosphorylation during the TNF (show TNF Antibodies)-related aoptosis-inducing ligand (TRAIL)-induced apoptosis.

  8. This study revealed critical function of GABAB R/GSK-3beta/NF-kappaB (show NFKB1 Antibodies) signaling pathway on regulating proliferation of colorectal cancer cell, which might provide a potential therapeutic target for clinical colorectal cancer treatment.

  9. PTEN (show PTEN Antibodies) and GSK3beta are targeted by miR (show MLXIP Antibodies)-29a, and miR (show MLXIP Antibodies)-29a may contribute to ADR (show AKR1B1 Antibodies) resistance through inhibition of the PTEN (show PTEN Antibodies)/AKT (show AKT1 Antibodies)/GSK3beta pathway in breast cancer cells. Thus, miR (show MLXIP Antibodies)-29a may be a potential target for the patients who acquired ADR (show AKR1B1 Antibodies)-resistance during the treatment of breast cancer.

  10. The analysis revealed three candidate genes GSK3B, PTPN1 (show PTPN1 Antibodies), STX4 (show STX4 Antibodies) that are differentially expressed in study subjects. GSK3B was highly significant in Ps-T2D (P=0.00018, FR=-26.6), followed by Ps (P=0.0028, FR=-14.5) and T2D groups (P=0.032, FR=-5.9). PTPN1 (show PTPN1 Antibodies) showed significant association only with PS-T2D (P=0.00027, FR=-8.5). STX4 (show STX4 Antibodies) showed significant association with both Ps (P=0.0002, FR=-20) and Ps-T2D (P=0.0016, FR=-11.2).

Xenopus laevis Glycogen Synthase Kinase 3 beta (GSK3b) interaction partners

  1. Novel roles for Plk (show PLK1 Antibodies) and GSK3 regulation of ADAM13 (show ADAM33 Antibodies) function in cranial neural crest cell migration.

  2. Interaction with Snail1 (show SNAI1 Antibodies)/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.

  3. These data suggest that the interactions of beta-catenin (show CTNNB1 Antibodies) with alpha-catenin (show CTNNA1 Antibodies) and GSK-3beta exert opposing effects on the terminal projections of ventral optic axons.

Zebrafish Glycogen Synthase Kinase 3 beta (GSK3b) interaction partners

  1. Both active and inactive forms of Gsk3b mediate the cooperative signaling during angiogenesis in zebrafish embryos.

  2. a novel negative, Gsk3beta-independent control mechanism of beta-catenin and implicates Ccr7 as a long-hypothesized GPCR regulating vertebrate axis formation.

  3. The regulatory target of Wnts and Igfs, GSK3beta, is inefficiently inactivated in male fin regenerates compared with females. Pharmacological inhibition of GSK3 in males increases blastemal proliferation and restores regenerative pattern.

  4. 2-OST (show HS2ST1 Antibodies) functions within the Wnt (show WNT2 Antibodies) pathway, downstream of Wnt (show WNT2 Antibodies) ligand signaling and upstream of Gsk3beta and beta-catenin (show CTNNB1 Antibodies) intracellular localization and function

  5. Data show that GSK-3beta inhibition was sufficient to stimulate MG dedifferentiation and the formation of multipotent retinal progenitors that were capable of differentiating into all major retinal cell types.

  6. GSK3alpha, but not GSK3beta, is necessary in cardiomyocyte survival

  7. Gsk3b regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (show SGPL1 Antibodies)) factor activity.

  8. A newly developed highly active GSK3beta inhibitor AR-534, reduced human TAU phosphorylation in TAU transgenic zebrafish.

Pig (Porcine) Glycogen Synthase Kinase 3 beta (GSK3b) interaction partners

  1. Five different isoforms of GSK3beta identified from porcine tissues, splice variants exhibit differential activity towards glycogen synthase.

  2. scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of GSK3beta activity which can lead to activation of the downstream signaling through beta-catenin (show CTNNB1 Antibodies)

  3. There was no correlation of infarct size with expression or phosphorylation of p70S6K (show RPS6KB1 Antibodies) or GSK3beta in ischemic postconditioning.

Cow (Bovine) Glycogen Synthase Kinase 3 beta (GSK3b) interaction partners

  1. GSK3B and phosphorylated GSK3B regulate milk synthesis and proliferation dairy cow mammary epithelial cells.

  2. GSK3B serine phosphorylation was positively correlated with embryo development

  3. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

  4. IGF-I (show IGF1 Antibodies) down-regulated functional IGF-I receptor (show IGF1R Antibodies) via GSK-3beta inhibition and mTOR (show FRAP1 Antibodies) activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Antibodies) level in nonstimulated cells.

  5. These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK-3beta-mediated phosphorylation of SH-binding proteins, including MBP (show MBP Antibodies) and tau protein.

  6. cAMP/PKA regulation of GSK3beta/beta-catenin (show CTNNB1 Antibodies) signaling contributes to the increase in progesterone production in corpus luteum.

GSK3 beta (GSK3b) Antigen Profile

Antigen Summary

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GSK3 beta (GSK3b)

  • glycogen synthase kinase 3 beta (Gsk3b) antibody
  • glycogen synthase kinase 3 beta (GSK3B) antibody
  • glycogen synthase kinase 3 beta (gsk3b) antibody
  • 7330414F15Rik antibody
  • 8430431H08Rik antibody
  • C86142 antibody
  • fk80d11 antibody
  • gsk-3 antibody
  • GSK-3beta antibody
  • GSK-3[b] antibody
  • gsk3 antibody
  • gsk3-beta antibody
  • GSK3beta antibody
  • wu:fb68h05 antibody
  • wu:fk80d11 antibody
  • xgsk-3 antibody

Protein level used designations for GSK3b

GSK-3 beta , glycogen synthase kinase-3 beta , serine/threonine-protein kinase GSK3B , FA , factor A , GSK3beta isoform , intracellular kinase , fb68h05 , glycogen synthase kinase 3 beta variant 1 , glycogen synthase kinase 3 beta variant 2 , glycogen synthase kinase 3 beta variant 3 , glycogen synthase kinase 3 beta variant 4 , GSK-3beta

GENE ID SPECIES
56637 Mus musculus
84027 Rattus norvegicus
2932 Homo sapiens
399097 Xenopus laevis
30654 Danio rerio
478575 Canis lupus familiaris
100126852 Sus scrofa
790875 Bos taurus
418335 Gallus gallus
100348842 Oryctolagus cuniculus
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