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Browse our anti-LEF1 (LEF1) Antibodies

Full name:
anti-Lymphoid Enhancer-Binding Factor 1 Antibodies (LEF1)
On are 126 Lymphoid Enhancer-Binding Factor 1 (LEF1) Antibodies from 24 different suppliers available. Additionally we are shipping LEF1 Proteins (7) and LEF1 Kits (3) and many more products for this protein. A total of 146 LEF1 products are currently listed.
3000002B05, AI451430, LEF-1, LEF1, TCF1ALPHA, TCF7L3, TCF10

Most Popular Reactivities for anti-LEF1 (LEF1) Antibodies

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anti-Mouse (Murine) LEF1 Antibodies:

anti-Rat (Rattus) LEF1 Antibodies:

anti-Human LEF1 Antibodies:

All available anti-LEF1 Antibodies

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Top referenced anti-LEF1 Antibodies

  1. Human Polyclonal LEF1 Primary Antibody for IF, WB - ABIN655987 : Gutierrez, Tschumper, Wu, Shanafelt, Eckel-Passow, Huddleston, Slager, Kay, Jelinek: LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis. in Blood 2010 (PubMed)
    Show all 4 references for ABIN655987

  2. Human Monoclonal LEF1 Primary Antibody for WB - ABIN1882259 : Kalsi, Kuo, Aliev, Alexander, McMichael, Patterson, Walsh, Zhao, Schuckit, Nurnberger, Edenberg, Kramer, Hesselbrock, Tischfield, Vladimirov, Prescott, Dick, Kendler, Riley: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. in Human molecular genetics 2010 (PubMed)
    Show all 3 references for ABIN1882259

  3. Human Polyclonal LEF1 Primary Antibody for EIA, WB - ABIN953158 : Chen, Zhang, Pincus, Wu, Ricks, Liu, Sun, Maclaren, Lan: Human CD1D gene expression is regulated by LEF-1 through distal promoter regulatory elements. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 3 references for ABIN953158

  4. Human Polyclonal LEF1 Primary Antibody for ELISA, WB - ABIN185607 : Radtke, Clevers: Self-renewal and cancer of the gut: two sides of a coin. in Science (New York, N.Y.) 2005 (PubMed)
    Show all 2 references for ABIN185607

  5. Human Monoclonal LEF1 Primary Antibody for IF, WB - ABIN264381 : Hsu, Galceran, Grosschedl: Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin. in Molecular and cellular biology 1998 (PubMed)

  6. Human Polyclonal LEF1 Primary Antibody for IF (p), IHC (p) - ABIN1387756 : Fu, Huang, Wang, Chen, Huang, Lu, Liang, Zhang: Proteome Profile and Quantitative Proteomic Analysis of Buffalo (Bubalusbubalis) Follicular Fluid during Follicle Development. in International journal of molecular sciences 2016 (PubMed)

  7. Cow (Bovine) Polyclonal LEF1 Primary Antibody for WB - ABIN2792635 : Petropoulos, Arseni, Schessl, Stadler, Rawat, Deshpande, Heilmeier, Hiddemann, Quintanilla-Martinez, Bohlander, Feuring-Buske, Buske: A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis. in The Journal of experimental medicine 2008 (PubMed)

  8. Chicken Polyclonal LEF1 Primary Antibody for IHC, WB - ABIN2779620 : Liu, Driskell, Luo, Abbott, Filali, Cheng, Sigmund, Engelhardt: Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin. in The Journal of investigative dermatology 2004 (PubMed)

More Antibodies against LEF1 Interaction Partners

Zebrafish Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. Amotl2a (show AMOTL2 Antibodies) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (show YAP1 Antibodies) and the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) effector Lef1.

  2. Lef1 has a role in regulating Dusp6 (show DUSP6 Antibodies) in formation of the zebrafish posterior lateral line primordium

  3. Nlk2 (show NLK Antibodies) is essential for the phosphorylation and activation of Lef1 transcriptional activity in neural progenitor cells.

  4. Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium.

  5. Lef1 sustains proliferation of leading zone progenitors, maintaining the primordium size and defining neuromast deposition rate.

  6. Data conclude that lef1-mediated Wnt (show WNT2 Antibodies) signaling is involved in various aspects of primordium migration, although part of this implication is masked by a high level of developmental redundancy.

  7. Data show cooperation between Dnmt3 and an H3K9 methyltransferase G9a (show EHMT2 Antibodies) in regulating lef1.

  8. high-affinity binding sites for Tcf (show HNF4A Antibodies)/Lef1 within the boz promoter region

  9. Canonical Wnt (show WNT2 Antibodies) signaling through Lef1 is required for hypothalamic neurogenesis.

  10. Domain-specific regulation of foxP2 (show FOXP2 Antibodies) CNS expression by lef1.

Mouse (Murine) Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. leukemic stem cells are therefore more sensitive to loss of Tcf1 (show HNF1A Antibodies) and Lef1 than Hematopoietic Stem Cells in their self-renewal capacity.

  2. Sp5 (show SP5 Antibodies)/8 bind directly to GC boxes in Wnt (show WNT2 Antibodies) target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1 (show HNF1A Antibodies)/lymphoid enhancer factor (Lef) 1 to facilitate recruitment of beta-catenin (show CTNNB1 Antibodies) to target gene enhancers.

  3. This paper demonstrates a cell-intrinsic requirement for transcription factors TCF1 (show HNF1A Antibodies) and LEF1 for the development of all subsets of Natural Killer T cells.

  4. this study gives new insights into transcriptional regulating mechanisms of Wnt (show WNT2 Antibodies)-mediated Isl1 (show ISL1 Antibodies) expression during cardiomyocyte differentiation.

  5. data reveal LEF1 as a central regulator of iNKT cell number and Th2-type effector differentiation.

  6. These findings provide evidence for the existance of a posititve feedback loop connecting survivin expression in tumor cells to PI3K/Akt enhanced beta-catenin-Tcf/Lef-dependent transcription followed by secretion of VEGF and angiogenesis.

  7. TDG (show TDG Antibodies), as a new coactivator, promotes beta-catenin (show CTNNB1 Antibodies)/TCFs transactivation and functionally cooperates with CBP (show CREBBP Antibodies) in canonical Wnt (show WNT2 Antibodies) signaling.

  8. TCF-1 (show HNF1A Antibodies) and LEF-1 adopted distinct genetic 'wiring' to promote the CD4 (show CD4 Antibodies)(+) T cell fate and establish CD8 (show CD8A Antibodies)(+) T cell identity.

  9. Postnatal isoform switch and protein localization of LEF1 and TCF7L2 (show TCF7L2 Antibodies) transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain.

  10. Activation of beta-catenin (show CTNNB1 Antibodies)/TCF (show HNF4A Antibodies) signaling by lysophosphatidic acid may be involved in neurogenesis by controlling the survival of neural precursors.

Xenopus laevis Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. Tcf (show HNF4A Antibodies)/Lef genes encode factors of different activities, which function together in antagonistic or synergistic ways to modulate the intensity and outcome of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signalling and to trigger tissue-specific responses.

  2. Interaction of Xom and LEF1/TCF (show HNF4A Antibodies)-factors is essential for ventral cell fate determination and LEF1/TCF (show HNF4A Antibodies) factors may function as a point of convergence to mediate the combined signaling of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and BMP4 (show BMP4 Antibodies)/Xom pathways during early embryogenesis.

Human Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. a frequency of 4-9% expression of LEF1 bymantle cell lymphoma

  2. The results suggest a role for beta-catenin (show CTNNB1 Antibodies)/LEF1-mediated transcription in both malignant transformation and metastasis of prostate cancer

  3. The results describe a novel mutation in LEF1 causing dysregulation of Wnt/B catenin signaling in eyelid sebaceous cancinoma

  4. LEF-1 and MITF (show MITF Antibodies) regulate tyrosinase (show TYR Antibodies) gene transcription in vitro via binding to its promoter.

  5. Methylprednisolone can suppress Wnt (show WNT2 Antibodies) signaling pathway by down-regulating LEF-1 protein expression in chronic lymphocyte leukemia cells.

  6. Overexpression of LEF1 is a favorable prognostic factor in childhood ALL.

  7. Authors found that the N-terminus of delta-catenin (show CTNND2 Antibodies) bound to the middle region of LEF-1 unlike beta-catenin (show CTNNB1 Antibodies). Overexpressed delta-catenin (show CTNND2 Antibodies) entered the nucleus and inhibited LEF-1-mediated transcriptional activity in Bosc23 and DLD (show DLD Antibodies)-1 cell lines.

  8. high LEF1 expression and mutation are associated with high-risk leukemia and our results also revealed that LEF1 high expression and/or gain-of-function mutations are involved in leukemogenesis of ALL.

  9. Study found a negative correlation between miR (show MLXIP Antibodies)-34a and LEF1 expression in prostate cancer cell lines and tumors and that miR (show MLXIP Antibodies)-34a regulated epithelial-mesenchymal transition through direct binding to LEF1 mRNA 3' UTR (show UTS2R Antibodies) region and silencing its translation.

  10. Our study suggests LEF1 expression in oral squamous cell carcinoma may play an important role in tumor progression and can be served as a predictor of poor prognosis for patients with oral squamous cell carcinoma.

Pig (Porcine) Lymphoid Enhancer-Binding Factor 1 (LEF1) interaction partners

  1. The molecular characterisation of the porcine LEF1 gene and its association with number of teats and inverted teats in experimental and commercial populations, is described.

LEF1 Antigen Profile

Antigen Summary

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with LEF1

  • lymphoid enhancer-binding factor 1 (LEF1) antibody
  • lymphoid enhancer-binding factor 1 (LOC100352691) antibody
  • lymphoid enhancer-binding factor 1 (lef1) antibody
  • lymphocyte enhancer binding factor 1 (lef1) antibody
  • lymphoid enhancer binding factor 1 (Lef1) antibody
  • lymphoid enhancer factor XLEF-1B (lef1) antibody
  • 3000002B05 antibody
  • AI451430 antibody
  • LEF-1 antibody
  • LEF1 antibody
  • TCF1ALPHA antibody
  • TCF7L3 antibody
  • TCF10 antibody

Protein level used designations for LEF1

lymphoid enhancer binding factor-1 , lymphoid enhancer-binding factor 1 , lymphoid enhancer-binding factor 1-like , etID310027.1 , LEF-1 , lymphoid enhancer binding factor 1 short isoform , T cell-specific transcription factor 1-alpha , TCF1-alpha , lymphiod enhancer binding factor 1 , transcription factor LEF-1 , lymphoid enhancer binding factor 1

461425 Pan troglodytes
695776 Macaca mulatta
100011783 Monodelphis domestica
100352691 Oryctolagus cuniculus
100399759 Callithrix jacchus
100447785 Pongo abelii
100465982 Ailuropoda melanoleuca
100556215 Anolis carolinensis
100593051 Nomascus leucogenys
30701 Danio rerio
16842 Mus musculus
161452 Rattus norvegicus
779101 Xenopus laevis
51176 Homo sapiens
395865 Gallus gallus
478507 Canis lupus familiaris
100170126 Sus scrofa
535399 Bos taurus
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