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anti-Mouse (Murine) PYGO1 Antibodies:
anti-Rat (Rattus) PYGO1 Antibodies:
anti-Human PYGO1 Antibodies:
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even in the absence of the potentially redundant Pygo1, Pygo2 (show PYGO2 Antibodies) does not require the H3K4me2/3 binding activity to sustain its function during mouse development
In mammals, the Pygo1/Pygo2 (show PYGO2 Antibodies) genes are not absolutely required for canonical Wnt (show WNT2 Antibodies) signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt (show WNT2 Antibodies) signal intensity
These results suggest that the Pygopus1 plant homeodomain (PHD (show PDC Antibodies)) dimerization is functionally important for Lgs/Bcl9 (show BCL9 Antibodies) recognition as well as for the regulation of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
Data show that human and Drosophila Pygo PHD (show PDC Antibodies) fingers associate with their cognate HD1 (show HDAC1 Antibodies) domains from BCL9/Legless (show BCL9 Antibodies) to bind specifically to the histone H3 (show HIST3H3 Antibodies) tail methylated at lysine 4 (H3K4me).
Involved in signal transduction through the Wnt pathway (By similarity).
pygopus homolog 1
, pygopus 1
, pygopus-like protein 1