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Browse our SFRP4 Proteins (SFRP4)

Full name:
Secreted Frizzled-Related Protein 4 Proteins (SFRP4)
On www.antibodies-online.com are 19 Secreted Frizzled-Related Protein 4 (SFRP4) Proteins from 8 different suppliers available. Additionally we are shipping SFRP4 Antibodies (90) and SFRP4 Kits (18) and many more products for this protein. A total of 135 SFRP4 products are currently listed.
Synonyms:
FRP-4, FRPHE, sFRP-4, SFRP4
list all proteins Gene Name GeneID UniProt
SFRP4 6424 Q6FHJ7
SFRP4 20379 Q9Z1N6
SFRP4 89803 Q9JLS4

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SFRP4 Proteins (SFRP4) by Origin

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Top referenced SFRP4 Proteins

  1. Mouse (Murine) SFRP4 Protein expressed in Human Cells - ABIN2007238 : Jones, Jomary: Secreted Frizzled-related proteins: searching for relationships and patterns. in BioEssays : news and reviews in molecular, cellular and developmental biology 2002 (PubMed)
    Show all 4 references for ABIN2007238

  2. Human SFRP4 Protein expressed in CHO Cells - ABIN2003300 : Drake, Friis, Dharmarajan: The role of sFRP4, a secreted frizzled-related protein, in ovulation. in Apoptosis : an international journal on programmed cell death 2003 (PubMed)
    Show all 3 references for ABIN2003300

  3. Human SFRP4 Protein expressed in Human Cells - ABIN2003298 : Wolf, Ke, Dharmarajan, Bielke, Artuso, Saurer, Friis: DDC-4, an apoptosis-associated gene, is a secreted frizzled relative. in FEBS letters 1998 (PubMed)
    Show all 3 references for ABIN2003298

  4. Human SFRP4 Protein expressed in Wheat germ - ABIN1319736 : Jacob, Ukegjini, Nixdorf, Ford, Olivier, Caduff, Scurry, Guertler, Hornung, Mueller, Fink, Hacker, Heinzelmann-Schwarz: Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients. in PLoS ONE 2012 (PubMed)

More Proteins for SFRP4 Interaction Partners

Human Secreted Frizzled-Related Protein 4 (SFRP4) interaction partners

  1. Down-regulation of SFRP4 is associated with recurrence in Endometrioid Adenocarcinoma.

  2. proliferation of IGFBP5 (show IGFBP5 Proteins)-mutated cancer cells is selectively blocked by IGF-1R (show IGF1R Proteins) inhibitors

  3. concentrations of serum SFRP4 in T2DM and impaired glucose tolerance subjects were increased and were correlated closely with glycose metabolic disorder, the first-phase of glucose-stimulated insulin (show INS Proteins) secretion and chronic low-grade inflammation

  4. sFRP4 expression is inversely related to the aggressiveness of pituitary adenomas, and acts as a tumor suppressor.

  5. Wnt3a (show WNT3A Proteins) can modulate intracellular localisation and secretion of sFRP4.

  6. We found that miR (show MLXIP Proteins)-203 was significantly downregulated in OSF (show OSTF1 Proteins) tissues compared to that in normal buccal mucosa tissues, and that miR (show MLXIP Proteins)-203 negatively regulated secreted SFRP4 and positively regulated TM4SF1 (show TM4SF1 Proteins)

  7. Serum WISP2 (show WISP2 Proteins) correlated directly with fatty acid binding protein 4. Serum SFRP5 (show SFRP5 Proteins) did not differ between obese (n=32) vs. nonobese (n=25) PCOS women, but reference women had lower SFRP5 (show SFRP5 Proteins) (p<5x10(-6) as compared to both PCOS groups).

  8. Abdominal adipose tissue is a major contributor for circulating-SFRP4; SFRP4 has an important role in obese adipose tissue pathophysiology.

  9. SFRP4 concentrations are associated with impaired glucose and triglyceride metabolism

  10. findings suggest that an epigenetic event is critically involved in the pathogenesis of psoriasis, and the downregulation of SFRP4 by CpG island methylation is one possible mechanism contributing to the hyperplasia of epidermis in the disease

Cow (Bovine) Secreted Frizzled-Related Protein 4 (SFRP4) interaction partners

  1. Upregulation of Wnt (show WNT2 Proteins) antagonist SFRP4 and adipogenic gene expression following castration, contributes to increased intramuscular fat deposition in the longissimus dorsi muscle.

Mouse (Murine) Secreted Frizzled-Related Protein 4 (SFRP4) interaction partners

  1. Our study showed that Pyle's disease was caused by a deficiency of sFRP4 and that sFRP4-mediated cross-regulation between Wnt and BMP signaling was critical for achieving proper cortical-bone thickness and stability.

  2. MicroRNA-124 regulates cell specification in the cochlea through modulation of Sfrp4 and Sfrp5 (show SFRP5 Proteins).

  3. In diet-induced obesity, loss of SFRP4 alters body length and bone mineral density as well as energy expenditure and food intake. However, SFRP4 does not control glucose homeostasis and beta-cell mass in mice.

  4. MG-derived oxidative stress (not CpG demethylation) epigenetically and rapidly derepress sFRP-4 gene expression.

  5. findings suggest that an epigenetic event is critically involved in the pathogenesis of psoriasis, and the downregulation of SFRP4 by CpG island methylation is one possible mechanism contributing to the hyperplasia of epidermis in the disease

  6. extra-follicular modulators Bmp2 (show BMP2 Proteins), Dkk1 (show DKK1 Proteins), and Sfrp4 increase in early anagen.

  7. studies indicate that mutations neither in sFRP1 (show SFRP1 Proteins) nor in sFRP4 are a common cause of craniotubular hyperostoses

  8. Data suggest that Sfrp4 does not contribute to the long-term regulation of serum phosphate levels in mice.

  9. sFRP4 negatively regulates bone formation without disrupting phosphorus homeostasis.

  10. the first promoter analysis of mouse Frp (show FRZB Proteins) genes providing the basis for understanding the functions and the regulation of Frp (show FRZB Proteins) and its role in regulating Wnt (show WNT2 Proteins) signals

SFRP4 Protein Profile

Protein Summary

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.

Alternative names and synonyms associated with SFRP4

  • secreted frizzled-related protein 4 (SFRP4)
  • secreted frizzled-related protein 4 (Sfrp4)
  • FRP-4 protein
  • FRPHE protein
  • sFRP-4 protein
  • SFRP4 protein

Protein level used designations for SFRP4

secreted frizzled-related protein 4 , secreted frizzled-related protein 4-like , frizzled protein, human endometrium , secreted frizzled-related protein 4; secreted frizzled-related protein 4 , secreted frizzled-relatedprotein 4 , FRP-4 , frizzled-related protein 4 , sFRP-4 , secreted frizzled-related sequence protein 4 , DDC-4 protein , FRP , frizzled related protein , frizzled-related protein

GENE ID SPECIES
420732 Gallus gallus
463356 Pan troglodytes
100449407 Pongo abelii
100592334 Nomascus leucogenys
6424 Homo sapiens
100145890 Sus scrofa
518004 Bos taurus
20379 Mus musculus
89803 Rattus norvegicus
483258 Canis lupus familiaris
574393 Macaca mulatta
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