SFRP4 Protein (His tag)
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- Target See all SFRP4 Proteins
- SFRP4 (Secreted Frizzled-Related Protein 4 (SFRP4))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SFRP4 protein is labelled with His tag.
- Purpose
- Recombinant Mouse sFRP4 Protein (His Tag)
- Sequence
- Met 1-Ser 351
- Characteristics
- A DNA sequence encoding the mouse sFRP4 (NP_057896.1) (Met 1-Ser 351) was expressed with a C-terminal polyhistidine tag.
- Purity
- > 97 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product SFRP4 Protein
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Secreted Frizzled-Related Protein 4 (SFRP4) (AA 211-312) protein (GST tag)
SFRP4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Secreted Frizzled-Related Protein 4 (SFRP4) (AA 19-346) protein (His tag)Crystallography grade SFRP4 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Secreted Frizzled-Related Protein 4 (SFRP4) (AA 19-351) protein (His tag)Crystallography grade SFRP4 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- SFRP4 (Secreted Frizzled-Related Protein 4 (SFRP4))
- Alternative Name
- sFRP4 (SFRP4 Products)
- Synonyms
- SFRP4 Protein, FRP-4 Protein, FRPHE Protein, sFRP-4 Protein, secreted frizzled related protein 4 Protein, secreted frizzled-related protein 4 Protein, SFRP4 Protein, Sfrp4 Protein
- Background
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Background: SFRP family consists of five secreted glycoproteins in humans acting as extracellular signaling ligands. Each is approximately 300 amino acids in length and contains a cysteine-rich domain (CRD) that shares 30-50% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs act as soluble modulators of Wnt signaling, counteracting Wnt-induced effects at high concentrations and promoting them at lower concentrations. SFRPs are able to bind Wnt proteins and Fz receptors in the extracellular compartment. The interaction between SFRPs and Wnt proteins prevents the latter from binding the Fz receptors. The Wnt pathway plays a key role in embryonic development, cell differentiation and cell proliferation. SFRP4 is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins called FZ domain and a NTR domain . Mouse SFRP4 is highly expressed in the ovary, and is localized to granulosa cells of periovulatory follicles and corpora lutea. It plays a critical role in placental development and implantation, and is also an important factor in the development of the decidual fibrinoid zone, and in trophoblast apoptosis.
Synonym: Sfrp4
- Molecular Weight
- 39.4 kDa
- NCBI Accession
- NP_057896
- Pathways
- WNT Signaling
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