Browse our TCF4 Proteins (TCF4)

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Transcription Factor 4 Proteins (TCF4)
On are 9 Transcription Factor 4 (TCF4) Proteins from 4 different suppliers available. Additionally we are shipping TCF4 Antibodies (86) and TCF4 Kits (10) and many more products for this protein. A total of 111 TCF4 products are currently listed.
5730422P05Rik, ASP-I2, bHLHb19, E2-2, e2-A, E2.2, GE2, ITF-2, ITF-2b, ITF2, ME2, MITF-2A, MITF-2B, mTcf-4B, mTcf-4E, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, Tcf-4, Tcf4, TCF4B, TCF4E, TCF7L2, TFE, XE2, Xtcf-4, Xtcf4
list all proteins Gene Name GeneID UniProt
TCF4 6925 P15884
TCF4 21413 Q60722
TCF4 84382 Q62655

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TCF4 Proteins (TCF4) by Origin

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Top referenced TCF4 Proteins

  1. Human TCF4 Protein expressed in Wheat germ - ABIN1322369 : Schenkel, Zloza, Li, Narasipura, Al-Harthi: Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)

More Proteins for TCF4 Interaction Partners

Zebrafish Transcription Factor 4 (TCF4) interaction partners

  1. GRG5/AES (show AES Proteins) interacts with TCF4 (show TCF7L2 Proteins) and represses Wnt (show WNT2 Proteins)-mediated transcription both in human cells and zebrafish embryos.

Xenopus laevis Transcription Factor 4 (TCF4) interaction partners

  1. Data indicte that Tcf-1 (show HNF1A Proteins) and Lef-1 (show LEF1 Proteins) exhibit a function in the axis induction assay, which is lacking in Tcf-3 (show TCF3 Proteins) and -4.

  2. Tcf4 (show TCF7L2 Proteins) transcription factor cooperates in patterning the Xenopus brain.

Human Transcription Factor 4 (TCF4) interaction partners

  1. These findings suggest that the rs7903146 locus might exert its enhancer function by interacting with HMGB1 (show HMGB1 Proteins) in an allele dependent manner.

  2. TCF7L2 (show TCF7L2 Proteins) polymorphism is associated with colorectal cancer.

  3. Data show that FERM domain-containing protein 5 (FRMD5) is regulated by both beta-catenin and transcription factor 7-Like 2 protein (TCF7L2) in colon cancer cells.

  4. Altered DNA methylation (show HELLS Proteins) in TCF4 involves in the etiology of Bipolar disorder and Major Depressive disorder .

  5. We found that the genotype "AG" of rs9320010 and "GA" of rs7235757 decreased SCZ risk. In the genetic model analysis, we also observed that the allele "A" of rs9320010 and "G" of rs7235757 were inversely related with the risk of SCZ in the dominant model. Our study indicated that rs9320010, rs7235757, and rs1452787 were prominently associated with SCZ.

  6. Our work suggests that DM1 (show DMPK Proteins) patients are at risk for Fuchs' endothelial corneal dystrophy (FECD (show COL8a2 Proteins)). DMPK (show DMPK Proteins) mutations contribute to the genetic burden of FECD (show COL8a2 Proteins) but are uncommon. We establish a connection between two repeat expansion disorders converging upon RNA-MBNL1 (show MBNL1 Proteins) foci and FECD (show COL8a2 Proteins).

  7. the variation of the TCF7L2 (show TCF7L2 Proteins) gene in three Amerindian populations

  8. These data define the mechanism responsible for the repressive effects of nitric oxide (NO) on the transcriptional activity of beta-catenin (show CTNNB1 Proteins) and link eNOS (show NOS3 Proteins)-derived NO to the modulation by VEGF (show VEGFA Proteins) of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-induced endothelial cell proliferation.

  9. we show that TopoIIalpha forms protein-protein interactions with beta-catentin and TCF4 and interacts with Wnt (show WNT2 Proteins) response elements (WREs) and promoters of direct target genes of TCF (show HNF4A Proteins) transcription, including: MYC (show MYC Proteins), vimentin (show VIM Proteins), AXIN2 (show AXIN2 Proteins) and LEF1 (show LEF1 Proteins)

  10. novel TCF7L2 (show TCF7L2 Proteins) type 2 diabetes SNP identified from fine mapping in African American women

Mouse (Murine) Transcription Factor 4 (TCF4) interaction partners

  1. We report that TCF4 comprises two transcriptional isoforms, both of which are required for optimal plasmacytoid DC development in vitro

  2. these data identified E2A (show TCF3 Proteins) and E2-2 as central regulators of B cell immunity.

  3. down-regulation of Id3 (show ID3 Proteins) in B cells is essential for releasing E2A (show TCF3 Proteins) and E2-2, which in a redundant manner are required for antigen-induced B cell differentiation.

  4. TCF7L2 (show TCF7L2 Proteins) mediates canonic Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and c-Myc (show MYC Proteins) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) to c-Myc (show MYC Proteins) axis can be explored for preventing and treating heart failure.

  5. TCF-4 as a co-activator of p65 (show NFkBP65 Proteins) in the potentiation of proinflammatory cytokine production in macrophages and aggravation of high-fat diet induced chronic inflammation and insulin (show INS Proteins) resistance in mice.

  6. These findings suggest a unique role for Tcf7l2 (show TCF7L2 Proteins) in generating distinct neuronal phenotypes from homogeneous progenitor population.

  7. Tcf7l2 (show TCF7L2 Proteins) may be involved in maintenance of stem/progenitor cells properties.

  8. Data indicate that upregulation of E2-2 protein markedly attenuated the inhibitor of DNA-binding 1 (ID1 (show ID1 Proteins))-mediated increase in endothelial progenitor cells (EPCs) proliferation and migration.

  9. results indicate that miR (show MLXIP Proteins)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) and Wnt (show WNT2 Proteins) signaling pathway by directly targeting Smad7 (show SMAD7 Proteins) and Tcf7l2 (show TCF7L2 Proteins)

  10. Tcf7l2 (show TCF7L2 Proteins) protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.

TCF4 Protein Profile

Protein Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Alternative names and synonyms associated with TCF4

  • transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2)
  • transcription factor 4 (tcf4)
  • transcription factor 4 (TCF4)
  • transcription factor 4 (Tcf4)
  • transcription factor 7 like 2, T cell specific, HMG box (Tcf7l2)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (LOC396347)
  • 5730422P05Rik protein
  • ASP-I2 protein
  • bHLHb19 protein
  • E2-2 protein
  • e2-A protein
  • E2.2 protein
  • GE2 protein
  • ITF-2 protein
  • ITF-2b protein
  • ITF2 protein
  • ME2 protein
  • MITF-2A protein
  • MITF-2B protein
  • mTcf-4B protein
  • mTcf-4E protein
  • PTHS protein
  • SEF-2 protein
  • SEF2 protein
  • SEF2-1 protein
  • SEF2-1A protein
  • SEF2-1B protein
  • Tcf-4 protein
  • Tcf4 protein
  • TCF4B protein
  • TCF4E protein
  • TCF7L2 protein
  • TFE protein
  • XE2 protein
  • Xtcf-4 protein
  • Xtcf4 protein

Protein level used designations for Transcription Factor 4 Proteins (TCF4)

transcription factor 7-like 2 (T-cell specific, HMG-box) , transcription factor 4 , transcription factor 4-like , tcf4l , helix-loop-helix transcription factor , SL3-3 enhancer factor 2 , class B basic helix-loop-helix protein 19 , immunoglobulin transcription factor 2 , ITF-2 , TCF-4 , thyroglobulin promoter transcription factor TFE , transcriptional factor 4 , MITF-2 , Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2) , class A helix-loop-helix transcription factor ME2 , immunoglobulin transcription factor-2 , R8f DNA-binding protein , RITF-2 , SEF-2 , HMG box transcription factor 4 , T-cell factor 4 , T-cell-specific transcription factor 4 , mTCF-4 , transcription factor 7-like 2 , transcription factor 7-like 2, T-cell specific, HMG-box , transcription factor Tcf4 , T-cell factor-4 variant A , T-cell factor-4 variant B , T-cell factor-4 variant C , T-cell factor-4 variant D , T-cell factor-4 variant E , T-cell factor-4 variant F , T-cell factor-4 variant G , T-cell factor-4 variant H , T-cell factor-4 variant I , T-cell factor-4 variant J , T-cell factor-4 variant K , T-cell factor-4 variant L , T-cell factor-4 variant M , T-cell factor-4 variant X2 , hTCF-4

100049930 Equus caballus
100445658 Pongo abelii
100526651 Danio rerio
373726 Xenopus laevis
6925 Homo sapiens
403949 Canis lupus familiaris
534935 Bos taurus
21413 Mus musculus
84382 Rattus norvegicus
100511671 Sus scrofa
21416 Mus musculus
395508 Gallus gallus
6934 Homo sapiens
396347 Gallus gallus
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