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Browse our TCF4 Proteins (TCF4)

Full name:
Transcription Factor 4 Proteins (TCF4)
On are 9 Transcription Factor 4 (TCF4) Proteins from 4 different suppliers available. Additionally we are shipping TCF4 Antibodies (82) and TCF4 Kits (10) and many more products for this protein. A total of 107 TCF4 products are currently listed.
5730422P05Rik, ASP-I2, bHLHb19, E2-2, e2-A, E2.2, GE2, ITF-2, ITF-2b, ITF2, ME2, MITF-2A, MITF-2B, mTcf-4B, mTcf-4E, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, Tcf-4, Tcf4, TCF4B, TCF4E, TCF7L2, TFE, XE2, Xtcf-4, Xtcf4
list all proteins Gene Name GeneID UniProt
TCF4 6925 P15884
TCF4 21413 Q60722
TCF4 84382 Q62655

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TCF4 Proteins (TCF4) by Origin

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Top referenced TCF4 Proteins

  1. Human TCF4 Protein expressed in Wheat germ - ABIN1322369 : Schenkel, Zloza, Li, Narasipura, Al-Harthi: Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)

More Proteins for TCF4 Interaction Partners

Zebrafish Transcription Factor 4 (TCF4) interaction partners

  1. GRG5/AES (show AES Proteins) interacts with TCF4 (show TCF7L2 Proteins) and represses Wnt (show WNT2 Proteins)-mediated transcription both in human cells and zebrafish embryos.

Xenopus laevis Transcription Factor 4 (TCF4) interaction partners

  1. Data indicte that Tcf-1 (show HNF1A Proteins) and Lef-1 (show LEF1 Proteins) exhibit a function in the axis induction assay, which is lacking in Tcf-3 (show TCF3 Proteins) and -4.

  2. Tcf4 (show TCF7L2 Proteins) transcription factor cooperates in patterning the Xenopus brain.

Human Transcription Factor 4 (TCF4) interaction partners

  1. Data indicate that triglycerides were significantly associated with the T risk allele of the transcription factor 7-like 2 (TCF7L2 (show TCF7L2 Proteins)) gene.

  2. Transcription factor 7-like 2 (TCF7L2 (show TCF7L2 Proteins)) gene encodes the TCF-4 transcription factor, which forms a part of the Wnt (show WNT2 Proteins) signaling pathway.

  3. The T allele of TCF7L2 (show TCF7L2 Proteins) rs7903146 polymorphism was associated with susceptibility of gestational diabetes mellitus in overall population in white, Hispanic/Latino and Asian sub-groups. Meta-analysis.

  4. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (show ADCY5 Proteins), ADRA2A (show ADRA2A Proteins), CDKAL1 (show CDKAL1 Proteins), CDKN2A/B, GRB10 (show GRB10 Proteins), and TCF7L2 (show TCF7L2 Proteins)

  5. The T-allele frequencies of TCF7L2 (show TCF7L2 Proteins) polymorphisms rs12255372 and rs7903146 were 30% (26-35%), 32% (27-37%) and 29% (25-34%), 36% (31-41%), respectively.

  6. the beta-catenin (show CTNNB1 Proteins)/Tcf4 interaction is disrupted by BC-23

  7. GRbeta bound to the N-terminus domain of TCF-4 its influence on Wnt (show WNT2 Proteins) signaling required both ligand- and DNA-binding domains. This is enough to maintain the TCF (show HNF4A Proteins)/LEF activity at a high level in the absence of beta-catenin (show CTNNB1 Proteins) stabilization.

  8. Despite limited sample size, the study indicates that rs7903146-T allele in TCF7L2 (show TCF7L2 Proteins) was associated with higher mean nocturnal glucose dependent on body composition, which might suggest that rs7902146 affects liver-specific aspects of glucose metabolism.

  9. The data suggest that changes in the transcript level containing constitutive TCF4 exon encoding the amino-terminal part of the protein seem not to contribute to disease pathogenesis.

  10. TCF7L2 (show TCF7L2 Proteins) rs10885409 C allele is a T2DM risk factor in Emiratis; this association is modulated by obesity status, but the Pro12Ala mutation in PPAR-gamma2 (show PPARG Proteins) is not associated with T2DM risk in this population

Mouse (Murine) Transcription Factor 4 (TCF4) interaction partners

  1. Kaiso (show ZBTB33 Proteins) and Sox10 (show SOX10 Proteins) sequentially interact with Tcf7l2 (show TCF7L2 Proteins) to coordinate the maturation of oligodendrocyte.

  2. TCF4 is a regulator of neuronal intrinsic excitability in part by repression of Kcnq1 (show KCNQ1 Proteins) and Scn10a (show SCN10A Proteins).

  3. A disease-promoting role of E2-2 dependent pDCs in the pancreas.

  4. Tcf7l2 (show TCF7L2 Proteins) plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination

  5. Genetic disruption of Itf2 on the Apc (show APC Proteins)(Min/+) background results in earlier death and a significant increase in tumor number and size in the small intestine.

  6. Tcf7l2 (show TCF7L2 Proteins) is regulating proinsulin (show INS Proteins) expression directly via Isl1 (show ISL1 Proteins), Ins1 and indirectly via MafA (show MAFA Proteins), NeuroD1 (show NEUROD1 Proteins) and Pdx1 (show PDX1 Proteins).

  7. Transcription factor 7-like 2 (show TCF7L2 Proteins) positively regulates neonatal and postnatal mouse oligodendrocyte differentiation during developmental myelination and remyelination in a manner independent of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.

  8. TCF7L2 (show TCF7L2 Proteins) expressed in the pancreatic beta cells plays a crucial role in glucose metabolism through regulation of the beta cell mass.

  9. Results show that binding of the transcription factor Tcf4 (show TCF7L2 Proteins) correlates with hypo-methylation and demonstrate that Tcf4 is one of the factors contributing to formation of differentially methylated regions.

  10. Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) stimulation may repress BACE1 (show BACE Proteins) transcription via binding of TCF4 to BACE1 (show BACE Proteins) gene, and therefore, activation of the Wnt (show WNT2 Proteins) pathway may hold the key to new treatments of Alzheimer disease

TCF4 Protein Profile

Protein Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Alternative names and synonyms associated with TCF4

  • transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2)
  • transcription factor 4 (tcf4)
  • transcription factor 4 (TCF4)
  • transcription factor 4 (Tcf4)
  • transcription factor 7 like 2, T cell specific, HMG box (Tcf7l2)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (LOC396347)
  • 5730422P05Rik protein
  • ASP-I2 protein
  • bHLHb19 protein
  • E2-2 protein
  • e2-A protein
  • E2.2 protein
  • GE2 protein
  • ITF-2 protein
  • ITF-2b protein
  • ITF2 protein
  • ME2 protein
  • MITF-2A protein
  • MITF-2B protein
  • mTcf-4B protein
  • mTcf-4E protein
  • PTHS protein
  • SEF-2 protein
  • SEF2 protein
  • SEF2-1 protein
  • SEF2-1A protein
  • SEF2-1B protein
  • Tcf-4 protein
  • Tcf4 protein
  • TCF4B protein
  • TCF4E protein
  • TCF7L2 protein
  • TFE protein
  • XE2 protein
  • Xtcf-4 protein
  • Xtcf4 protein

Protein level used designations for Transcription Factor 4 Proteins (TCF4)

transcription factor 7-like 2 (T-cell specific, HMG-box) , transcription factor 4 , transcription factor 4-like , tcf4l , helix-loop-helix transcription factor , SL3-3 enhancer factor 2 , class B basic helix-loop-helix protein 19 , immunoglobulin transcription factor 2 , ITF-2 , TCF-4 , thyroglobulin promoter transcription factor TFE , transcriptional factor 4 , MITF-2 , Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2) , class A helix-loop-helix transcription factor ME2 , immunoglobulin transcription factor-2 , R8f DNA-binding protein , RITF-2 , SEF-2 , HMG box transcription factor 4 , T-cell factor 4 , T-cell-specific transcription factor 4 , mTCF-4 , transcription factor 7-like 2 , transcription factor 7-like 2, T-cell specific, HMG-box , transcription factor Tcf4 , T-cell factor-4 variant A , T-cell factor-4 variant B , T-cell factor-4 variant C , T-cell factor-4 variant D , T-cell factor-4 variant E , T-cell factor-4 variant F , T-cell factor-4 variant G , T-cell factor-4 variant H , T-cell factor-4 variant I , T-cell factor-4 variant J , T-cell factor-4 variant K , T-cell factor-4 variant L , T-cell factor-4 variant M , T-cell factor-4 variant X2 , hTCF-4

100049930 Equus caballus
100445658 Pongo abelii
100526651 Danio rerio
373726 Xenopus laevis
6925 Homo sapiens
403949 Canis lupus familiaris
534935 Bos taurus
21413 Mus musculus
84382 Rattus norvegicus
100511671 Sus scrofa
21416 Mus musculus
395508 Gallus gallus
6934 Homo sapiens
396347 Gallus gallus
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