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Browse our TCF4 Proteins (TCF4)

Full name:
Transcription Factor 4 Proteins (TCF4)
On are 9 Transcription Factor 4 (TCF4) Proteins from 4 different suppliers available. Additionally we are shipping TCF4 Antibodies (86) and TCF4 Kits (8) and many more products for this protein. A total of 109 TCF4 products are currently listed.
5730422P05Rik, ASP-I2, bHLHb19, E2-2, e2-A, E2.2, GE2, ITF-2, ITF-2b, ITF2, ME2, MITF-2A, MITF-2B, mTcf-4B, mTcf-4E, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, Tcf-4, Tcf4, TCF4B, TCF4E, TCF7L2, TFE, XE2, Xtcf-4, Xtcf4
list all proteins Gene Name GeneID UniProt
TCF4 6925 P15884
TCF4 21413 Q60722
TCF4 84382 Q62655

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TCF4 Proteins (TCF4) by Origin

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Top referenced TCF4 Proteins

  1. Human TCF4 Protein expressed in Wheat germ - ABIN1322369 : Schenkel, Zloza, Li, Narasipura, Al-Harthi: Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)

More Proteins for TCF4 Interaction Partners

Zebrafish Transcription Factor 4 (TCF4) interaction partners

  1. GRG5/AES (show AES Proteins) interacts with TCF4 (show TCF7L2 Proteins) and represses Wnt (show WNT2 Proteins)-mediated transcription both in human cells and zebrafish embryos.

Xenopus laevis Transcription Factor 4 (TCF4) interaction partners

  1. Data indicte that Tcf-1 (show HNF1A Proteins) and Lef-1 (show LEF1 Proteins) exhibit a function in the axis induction assay, which is lacking in Tcf-3 (show TCF3 Proteins) and -4.

  2. Tcf4 (show TCF7L2 Proteins) transcription factor cooperates in patterning the Xenopus brain.

Human Transcription Factor 4 (TCF4) interaction partners

  1. Our findings demonstrate that ENPP1 (show ENPP1 Proteins), TCF7L2 (show TCF7L2 Proteins), and FTO (show FTO Proteins) may predispose to T2DM in the mixed-ancestry population.

  2. G-17 caused the overexpression of beta-catenin (show CTNNB1 Proteins) and TCF-4.

  3. Analysis of SLC4A11 (show SLC4A11 Proteins), ZEB1, LOXHD1, COL8A2 (show COL8a2 Proteins) and TCF4 gene sequences in a multi-generational family with late-onset Fuchs corneal dystrophy found no evidence for found polymorophisms causing the disease in this specific pedigree.

  4. The results showed that the rs7903146 T allele of the TCF7L2 (show TCF7L2 Proteins) gene was positively correlated with an enhanced risk of type 2 diabetes mellitus in the allelic, heterozygote, homozygote, dominant, and recessive models. (Meta-analysis)

  5. Among the TCF4 variants, rs12966547 and rs8766 were significantly associated with earlier schizophrenia age of onset.

  6. Patients with the T/T genotype for the rs12255372 polymorphism of the transcription factor 7- like 2 (show TCF7L2 Proteins) gene present an increased colorectal cancer risk.

  7. We suggest that screening for mutations in TCF4 could be considered in the investigation of non-syndromic intellectual disability.

  8. We conclude that the TCF7L2 (show TCF7L2 Proteins) rs7903146 genetic polymorphism is independently associated with the risk of developing type 2 diabetes mellitus under co-dominant, dominant, and recessive models

  9. expanded TGC (show TGM2 Proteins) allele with more than 50 TGC (show TGM2 Proteins) repeats in intron 2 and the described risk allele G of the polymorphism rs613872 in intron 3 of the TCF4 gene appear as an association to FECD (show COL8a2 Proteins). The chance to be affected by FECD (show COL8a2 Proteins) is up to 30 times higher. With molecular genetics also donors with clinically unknown FECD (show COL8a2 Proteins) may be detected.

  10. Data show that HMG-box transcription factor 1 protein HBP1-mediated elevation of CDK (show CDK4 Proteins) inhibitor p21 (show CDKN1A Proteins) through the Mdm2 (show MDM2 Proteins)/p53 (show TP53 Proteins) and TCF4/EZH2 (show EZH2 Proteins) pathways contributes to both cellular senescence and tumor inhibition.

Mouse (Murine) Transcription Factor 4 (TCF4) interaction partners

  1. results indicate that miR (show MLXIP Proteins)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) and Wnt (show WNT2 Proteins) signaling pathway by directly targeting Smad7 (show SMAD7 Proteins) and Tcf7l2 (show TCF7L2 Proteins)

  2. Tcf7l2 (show TCF7L2 Proteins) protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.

  3. We conclude that E2-2 inhibited EPC (show TCF21 Proteins) proliferation via suppressing their autophagy, and E2-2 regulated EPC (show TCF21 Proteins) autophagy by mediating the expression of ATG7 (show ATG7 Proteins).

  4. demonstrated that Id1 (show ID1 Proteins) and E2-2 are critical regulators of EPCs function in vitro. Id1 (show ID1 Proteins) interacts with E2-2 and relieves the E2-2-mediated repression of FGFR1 (show FGFR1 Proteins) and VEGFR2 (show KDR Proteins) expression to modulate EPCs functions

  5. Kaiso (show ZBTB33 Proteins) and Sox10 (show SOX10 Proteins) sequentially interact with Tcf7l2 (show TCF7L2 Proteins) to coordinate the maturation of oligodendrocyte.

  6. TCF4 is a regulator of neuronal intrinsic excitability in part by repression of Kcnq1 (show KCNQ1 Proteins) and Scn10a (show SCN10A Proteins).

  7. A disease-promoting role of E2-2 dependent pDCs in the pancreas.

  8. Tcf7l2 (show TCF7L2 Proteins) plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination

  9. Genetic disruption of Itf2 on the Apc (show APC Proteins)(Min/+) background results in earlier death and a significant increase in tumor number and size in the small intestine.

  10. Tcf7l2 (show TCF7L2 Proteins) is regulating proinsulin (show INS Proteins) expression directly via Isl1 (show ISL1 Proteins), Ins1 and indirectly via MafA (show MAFA Proteins), NeuroD1 (show NEUROD1 Proteins) and Pdx1 (show PDX1 Proteins).

TCF4 Protein Profile

Protein Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Alternative names and synonyms associated with TCF4

  • transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2)
  • transcription factor 4 (tcf4)
  • transcription factor 4 (TCF4)
  • transcription factor 4 (Tcf4)
  • transcription factor 7 like 2, T cell specific, HMG box (Tcf7l2)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (LOC396347)
  • 5730422P05Rik protein
  • ASP-I2 protein
  • bHLHb19 protein
  • E2-2 protein
  • e2-A protein
  • E2.2 protein
  • GE2 protein
  • ITF-2 protein
  • ITF-2b protein
  • ITF2 protein
  • ME2 protein
  • MITF-2A protein
  • MITF-2B protein
  • mTcf-4B protein
  • mTcf-4E protein
  • PTHS protein
  • SEF-2 protein
  • SEF2 protein
  • SEF2-1 protein
  • SEF2-1A protein
  • SEF2-1B protein
  • Tcf-4 protein
  • Tcf4 protein
  • TCF4B protein
  • TCF4E protein
  • TCF7L2 protein
  • TFE protein
  • XE2 protein
  • Xtcf-4 protein
  • Xtcf4 protein

Protein level used designations for Transcription Factor 4 Proteins (TCF4)

transcription factor 7-like 2 (T-cell specific, HMG-box) , transcription factor 4 , transcription factor 4-like , tcf4l , helix-loop-helix transcription factor , SL3-3 enhancer factor 2 , class B basic helix-loop-helix protein 19 , immunoglobulin transcription factor 2 , ITF-2 , TCF-4 , thyroglobulin promoter transcription factor TFE , transcriptional factor 4 , MITF-2 , Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2) , class A helix-loop-helix transcription factor ME2 , immunoglobulin transcription factor-2 , R8f DNA-binding protein , RITF-2 , SEF-2 , HMG box transcription factor 4 , T-cell factor 4 , T-cell-specific transcription factor 4 , mTCF-4 , transcription factor 7-like 2 , transcription factor 7-like 2, T-cell specific, HMG-box , transcription factor Tcf4 , T-cell factor-4 variant A , T-cell factor-4 variant B , T-cell factor-4 variant C , T-cell factor-4 variant D , T-cell factor-4 variant E , T-cell factor-4 variant F , T-cell factor-4 variant G , T-cell factor-4 variant H , T-cell factor-4 variant I , T-cell factor-4 variant J , T-cell factor-4 variant K , T-cell factor-4 variant L , T-cell factor-4 variant M , T-cell factor-4 variant X2 , hTCF-4

100049930 Equus caballus
100445658 Pongo abelii
100526651 Danio rerio
373726 Xenopus laevis
6925 Homo sapiens
403949 Canis lupus familiaris
534935 Bos taurus
21413 Mus musculus
84382 Rattus norvegicus
100511671 Sus scrofa
21416 Mus musculus
395508 Gallus gallus
6934 Homo sapiens
396347 Gallus gallus
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