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Browse our TCF4 Proteins (TCF4)

Full name:
Transcription Factor 4 Proteins (TCF4)
On www.antibodies-online.com are 9 Transcription Factor 4 (TCF4) Proteins from 4 different suppliers available. Additionally we are shipping TCF4 Antibodies (82) and TCF4 Kits (9) and many more products for this protein. A total of 106 TCF4 products are currently listed.
Synonyms:
5730422P05Rik, ASP-I2, bHLHb19, E2-2, e2-A, E2.2, GE2, ITF-2, ITF-2b, ITF2, ME2, MITF-2A, MITF-2B, mTcf-4B, mTcf-4E, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, Tcf-4, Tcf4, TCF4B, TCF4E, TCF7L2, TFE, XE2, Xtcf-4, Xtcf4
list all proteins Gene Name GeneID UniProt
TCF4 6925 P15884
TCF4 21413 Q60722
TCF4 84382 Q62655

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TCF4 Proteins (TCF4) by Origin

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Top referenced TCF4 Proteins

  1. Human TCF4 Protein expressed in Wheat germ - ABIN1322369 : Schenkel, Zloza, Li, Narasipura, Al-Harthi: Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)

More Proteins for TCF4 Interaction Partners

Zebrafish Transcription Factor 4 (TCF4) interaction partners

  1. GRG5/AES (show AES Proteins) interacts with TCF4 (show TCF7L2 Proteins) and represses Wnt (show WNT2 Proteins)-mediated transcription both in human cells and zebrafish embryos.

Xenopus laevis Transcription Factor 4 (TCF4) interaction partners

  1. Data indicte that Tcf-1 (show HNF1A Proteins) and Lef-1 (show LEF1 Proteins) exhibit a function in the axis induction assay, which is lacking in Tcf-3 (show TCF3 Proteins) and -4.

  2. Tcf4 (show TCF7L2 Proteins) transcription factor cooperates in patterning the Xenopus brain.

Human Transcription Factor 4 (TCF4) interaction partners

  1. TCF7L2 (show TCF7L2 Proteins) mediates canonic Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and c-Myc (show MYC Proteins) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) to c-Myc (show MYC Proteins) axis can be explored for preventing and treating heart failure.

  2. We identify the transcription factors FOXA1 (show FOXA1 Proteins), MYB (show MYB Proteins), CDX2 (show CDX2 Proteins) and TCF7L2 (show TCF7L2 Proteins) as EPHB2 (show EPHB2 Proteins) enhancer factors and demonstrate that Snail1 (show SNAI1 Proteins) indirectly inactivates the EPHB2 (show EPHB2 Proteins) enhancer by downregulation of FOXA1 (show FOXA1 Proteins) and MYB (show MYB Proteins)

  3. We found that TCF7L1 (show TCF3 Proteins) recruits the C-terminal binding protein (CtBP (show CTBP2 Proteins)) and histone deacetylase 1 (HDAC1 (show HDAC1 Proteins)) to the DKK4 (show DKK4 Proteins) promoter to repress DKK4 (show DKK4 Proteins) gene expression. In the absence of TCF7L1 (show TCF3 Proteins), TCF7L2 (show TCF7L2 Proteins) and beta-catenin (show CTNNB1 Proteins) occupancy at the DKK4 (show DKK4 Proteins) promoter is stimulated and DKK4 (show DKK4 Proteins) expression is increased. These findings uncover a critical role for TCF7L1 (show TCF3 Proteins) in repressing DKK4 (show DKK4 Proteins) gene expression to promote the oncogenic potential of CRCs.

  4. Corneal endothelium from FECD (show COL8a2 Proteins) patients harbors a unique signature of mis (show AMH Proteins)-splicing events due to CTG TNR (show TNR Proteins) expansion in the TCF4 gene, consistent with the hypothesis that RNA toxicity contributes to the pathogenesis of FECD (show COL8a2 Proteins).

  5. nominally significant associations seen between TT genotype and the recessive model of TCF7L2 (show TCF7L2 Proteins) rs7903146 and increased risk of type 2 diabetes mellitus

  6. Genetic variation at TCF7L2 (show TCF7L2 Proteins) does not predispose an individual to type 2 diabetes by altering either hepatic or extrahepatic insulin (show INS Proteins) action.

  7. Results identify TCF4 as a crucial transcriptional regulator required for maintenance of blastic plasmacytoid dendritic cell neoplasm.

  8. Taken together, these results suggest that this newly identified Rock2 (show ROCK2 Proteins)-beta-catenin (show CTNNB1 Proteins)/TCF4-SCARA5 (show SCARA5 Proteins) axis will provide novel insight into the understanding of the regulatory mechanisms of proliferation in human RCC (show XRCC1 Proteins).

  9. In the sex-combined analyses, we identified one novel locus (TCF7L2/HABP2) for WHRadjBMI and eight previously established loci at P < 5x10-8: seven for BMI, and one for WHRadjBMI in African ancestry individuals. An additional novel locus (SPRYD7/DLEU2) was identified for WHRadjBMI when combined with European GWAS.

  10. In renal transplant patients, TCF7L2 (show TCF7L2 Proteins) rs7903146 is strongly and independently associated with posttransplant diabetes mellitus and might hold the potential to identify patients at risk for this complication.

Mouse (Murine) Transcription Factor 4 (TCF4) interaction partners

  1. TCF7L2 (show TCF7L2 Proteins) mediates canonic Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and c-Myc (show MYC Proteins) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) to c-Myc (show MYC Proteins) axis can be explored for preventing and treating heart failure.

  2. TCF-4 as a co-activator of p65 (show NFkBP65 Proteins) in the potentiation of proinflammatory cytokine production in macrophages and aggravation of high-fat diet induced chronic inflammation and insulin (show INS Proteins) resistance in mice.

  3. These findings suggest a unique role for Tcf7l2 (show TCF7L2 Proteins) in generating distinct neuronal phenotypes from homogeneous progenitor population.

  4. Tcf7l2 (show TCF7L2 Proteins) may be involved in maintenance of stem/progenitor cells properties.

  5. Data indicate that upregulation of E2-2 protein markedly attenuated the inhibitor of DNA-binding 1 (ID1 (show ID1 Proteins))-mediated increase in endothelial progenitor cells (EPCs) proliferation and migration.

  6. results indicate that miR (show MLXIP Proteins)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) and Wnt (show WNT2 Proteins) signaling pathway by directly targeting Smad7 (show SMAD7 Proteins) and Tcf7l2 (show TCF7L2 Proteins)

  7. Tcf7l2 (show TCF7L2 Proteins) protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.

  8. We conclude that E2-2 inhibited EPC (show TCF21 Proteins) proliferation via suppressing their autophagy, and E2-2 regulated EPC (show TCF21 Proteins) autophagy by mediating the expression of ATG7 (show ATG7 Proteins).

  9. demonstrated that Id1 (show ID1 Proteins) and E2-2 are critical regulators of EPCs function in vitro. Id1 (show ID1 Proteins) interacts with E2-2 and relieves the E2-2-mediated repression of FGFR1 (show FGFR1 Proteins) and VEGFR2 (show KDR Proteins) expression to modulate EPCs functions

  10. Kaiso (show ZBTB33 Proteins) and Sox10 (show SOX10 Proteins) sequentially interact with Tcf7l2 (show TCF7L2 Proteins) to coordinate the maturation of oligodendrocyte.

TCF4 Protein Profile

Protein Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Alternative names and synonyms associated with TCF4

  • transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2)
  • transcription factor 4 (tcf4)
  • transcription factor 4 (TCF4)
  • transcription factor 4 (Tcf4)
  • transcription factor 7 like 2, T cell specific, HMG box (Tcf7l2)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (LOC396347)
  • 5730422P05Rik protein
  • ASP-I2 protein
  • bHLHb19 protein
  • E2-2 protein
  • e2-A protein
  • E2.2 protein
  • GE2 protein
  • ITF-2 protein
  • ITF-2b protein
  • ITF2 protein
  • ME2 protein
  • MITF-2A protein
  • MITF-2B protein
  • mTcf-4B protein
  • mTcf-4E protein
  • PTHS protein
  • SEF-2 protein
  • SEF2 protein
  • SEF2-1 protein
  • SEF2-1A protein
  • SEF2-1B protein
  • Tcf-4 protein
  • Tcf4 protein
  • TCF4B protein
  • TCF4E protein
  • TCF7L2 protein
  • TFE protein
  • XE2 protein
  • Xtcf-4 protein
  • Xtcf4 protein

Protein level used designations for Transcription Factor 4 Proteins (TCF4)

transcription factor 7-like 2 (T-cell specific, HMG-box) , transcription factor 4 , transcription factor 4-like , tcf4l , helix-loop-helix transcription factor , SL3-3 enhancer factor 2 , class B basic helix-loop-helix protein 19 , immunoglobulin transcription factor 2 , ITF-2 , TCF-4 , thyroglobulin promoter transcription factor TFE , transcriptional factor 4 , MITF-2 , Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2) , class A helix-loop-helix transcription factor ME2 , immunoglobulin transcription factor-2 , R8f DNA-binding protein , RITF-2 , SEF-2 , HMG box transcription factor 4 , T-cell factor 4 , T-cell-specific transcription factor 4 , mTCF-4 , transcription factor 7-like 2 , transcription factor 7-like 2, T-cell specific, HMG-box , transcription factor Tcf4 , T-cell factor-4 variant A , T-cell factor-4 variant B , T-cell factor-4 variant C , T-cell factor-4 variant D , T-cell factor-4 variant E , T-cell factor-4 variant F , T-cell factor-4 variant G , T-cell factor-4 variant H , T-cell factor-4 variant I , T-cell factor-4 variant J , T-cell factor-4 variant K , T-cell factor-4 variant L , T-cell factor-4 variant M , T-cell factor-4 variant X2 , hTCF-4

GENE ID SPECIES
100049930 Equus caballus
100445658 Pongo abelii
100526651 Danio rerio
373726 Xenopus laevis
6925 Homo sapiens
403949 Canis lupus familiaris
534935 Bos taurus
21413 Mus musculus
84382 Rattus norvegicus
100511671 Sus scrofa
21416 Mus musculus
395508 Gallus gallus
6934 Homo sapiens
396347 Gallus gallus
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