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Human WIF1 Protein expressed in Wheat germ - ABIN1325330
Kansara, Tsang, Kodjabachian, Sims, Trivett, Ehrich, Dobrovic, Slavin, Choong, Simmons, Dawid, Thomas: Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. in The Journal of clinical investigation 2009
Study supported the hypothesis that Wnt inhibitory factor 1 (WIF1) is crucial as a negative regulator of the functions of endothelial cells in angiogenesis and that hypoxia plays an important role in controlling WIF1 expression and angiogenesis.
Our data suggests that total cellular b-catenin levels decrease in the presence of secreted frizzled-related protein 1 (show SFRP1 Proteins) and Wnt inhibitory factor 1, and a significant increase in cell death after tyrosine kinase (show TXK Proteins) inhibitor treatment is observed. On the contrary, when secreted frizzled-related protein 1 (show SFRP1 Proteins) is suppressed, total b-catenin levels increase in the cell and the cells become resistant to tyrosine kinase (show TXK Proteins) inhibitors.
Gallbladder cancer patients with hypermethylated WIF-1 exhibited worse overall survival than those with hypomethylated WIF-1.
In astrocytoma specimens, tumor areas with numerous single cells were identified which strongly express Wif-1.
Hypermethylation of WIF1 (WNT inhibitory factor 1) and NPY (neuropeptide Y (show NPY Proteins)) genes was significantly higher in tumor tissue compared to normal tissue, independently of tumor stage.
the expression levels of WIF-1 were low in gallbladder cancer tumor tissues and the GBC-SD, SGC (show SGCB Proteins)-996 and NOZ gallbladder cancer cell lines. This low expression was associated with the methylation status of the WIF-1 gene promotor.
Compared with adjacent normal tissues, the methylation frequencies of WIF-1, RASSF1A (show RASSF1 Proteins), and CDH13 (show CDH13 Proteins) genes were significantly higher but the mRNA levels of these 3 genes were significantly lower in EC tissues. The survival rates of patients with WIF-1, RASSF1A (show RASSF1 Proteins), and CDH13 (show CDH13 Proteins) methylations were significantly lower than those of patients without methylation
Promoter hypermethylation WIF1 play an important role in the carcinogenesis of lung cancer.
HOTAIR can affect the radiosensitivity of pancreatic ductal adenocarcinoma (PDAC) cells partly via regulating the expression of WIF-1, and HOTAIR-WIF-1 axis is a potential target for PDAC radiotherapy.
beta-catenin (show CTNNB1 Proteins) expression may also be a poor prognostic factor for cervical cancer (CC) while WIF1 could be a potential drug target for treatment of advanced CC.
Wif1 localizes to the enamel knot in which Wif1 regulates apoptosis by mediating and regulating Wnt (show WNT2 Proteins)-beta-catenin (show CTNNB1 Proteins) signaling. Thus, Wif1 plays an essential role in tooth development.
WIF1 has a role in breast neoplasms: its inhibition significantly relieves the cancer stem cell-limiting effects of dietary compound isoliquiritigenin
results demonstrate that Wif1 is not targeted for silencing by DNA methylation (show HELLS Proteins) in OS. Instead, the reduced expression of Wif1 in OS cells is in context with their stage in differentiation
EZH2 (show EZH2 Proteins)-induced downregulation of WIF1 expression may partially regulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-dependent crypt hyperplasia in response to citrobacter rodentium infection
Dysregulation of this endodermal Shh-Wif1-b-catenin signaling axis contributes to ARM pathogenesis.
It is anticipated that our findings will contribute to expansion of our understanding of WIF1 biological function on heart development and possible modes of treatment of heart diseases
WIF1 secretion by the Mullerian duct mesenchyme plays a role in Mullerian duct regression in fetal males
These data suggest that WIF-1 may take part in the fine-tuning of cartilage and bone turnover, promoting the balance of cartilage versus bone anabolism.
Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development
Osteoblastic Wif1 overexpression disrupts stem cell quiescence, leading to a loss of self-renewal potential.
In an examination of signaling pathways in developing Xenopus lung, wif1 was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Data describe the importance of proper level of Wnt (show WNT2 Proteins) signaling for normal development of swimbladder in Wif1 morphant zebrafish.
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers.
, wnt inhibitory factor 1
, WNT inhibitory factor 1
, wnt inhibitory factor 1-like
, Wnt inhibitory factor-1
, wnt inhibitory factor-1