WIF1 Protein (His tag)

Catalog No. ABIN7320086

Product Details

Target: WIF1 (WNT Inhibitory Factor 1 (WIF1))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This WIF1 protein is labelled with His tag.

Purpose: Recombinant Mouse Wnt Inhibitory Factor 1/WIF1 Protein (His Tag)

Sequence: Met1-Trp379

Characteristics: A DNA sequence encoding the mouse WIF1 (Q9WUA1) (Met1-Trp379) was expressed with a C-terminal polyhistidine tag.

Purity: > 93 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: WIF1 (WNT Inhibitory Factor 1 (WIF1))

Alternative Name: Wnt Inhibitory Factor 1/WIF1 (WIF1 Products)

Synonyms: shf Protein, GB10372 Protein, wif-1 Protein, WIF1 Protein, WIF-1 Protein, AW107799 Protein, zgc:110507 Protein, protein shifted Protein, wnt inhibitory factor 1 Protein, WNT inhibitory factor 1 Protein, Wnt inhibitory factor 1 Protein, WNT inhibitory factor 1 S homeolog Protein, LOC552805 Protein, CpipJ_CPIJ003761 Protein, wif1 Protein, WIF1 Protein, Wif1 Protein, LOC100511326 Protein, wif1.S Protein

Background:

Background: WIF1, also known as WIF-1 and wnt inhibitory factor 1, is a secreted protein which binds WNT proteins and inhibits their activities. It contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 may be involved in mesoderm segmentation and can be detected in fish, amphibia and mammals. WIF-1 is a recurrent target in human salivary gland oncogenesis. Downregulation of WIF1 takes part in the development and progression of pleomorphic adenomas. WIF1 also is a tumor suppressor, and has been found to be epigenetically silenced in various cancers, specifically in nonfunctioning pituitary tumors. WIF1 are expected to have molecular function (protein tyrosine kinase activity) and to localize in various compartments (extracellular space, extracellular region).

Synonym: AW107799,WIF-1

Molecular Weight: 39.8 kDa

UniProt: Q9WUA1

Pathways: WNT Signaling, Positive Regulation of fat Cell Differentiation