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anti-Human WNT5A Antibodies:
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Cow (Bovine) Polyclonal WNT5A Primary Antibody for IHC, IHC (p) - ABIN4366188
Rao, Liu, Zhou, Ma, Lu, Zhou: Expression analysis of Wnt-5a in renal epithelial neoplasms: distinguishing renal oncocytoma from a wide spectrum of renal cell carcinomas. in Tumori 2010
Show all 9 Pubmed References
Dog (Canine) Polyclonal WNT5A Primary Antibody for IF (p), IHC (p) - ABIN675758
Król, Mucha, Majchrzak, Homa, Bulkowska, Majewska, Gajewska, Pietrzak, Perszko, Romanowska, Paw?owski, Manuali, Hellmen, Motyl: Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors. in PLoS ONE 2014
Show all 2 Pubmed References
Human Monoclonal WNT5A Primary Antibody for IHC, ELISA - ABIN969461
Dai, Hall, Escara-Wilke, Mizokami, Keller, Keller: Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms. in Cancer research 2008
Show all 2 Pubmed References
Human Monoclonal WNT5A Primary Antibody for ICC, IHC - ABIN969460
Ford, Ekström, Andersson: Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 2 Pubmed References
Human Monoclonal WNT5A Primary Antibody for IF, IHC - ABIN967259
Martino, Olsen, Fulcher, Wolfgang, ONeal, Ribeiro: Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1. in The Journal of biological chemistry 2009
Show all 3 Pubmed References
Human Monoclonal WNT5A Primary Antibody for ELISA, ICC - ABIN2869402
Chang, Nam, Kook, Kim, Liu, Yao, Jung, Lemos, Seo, Park, Gim, Hong, Huh, Kim, Tan, Liu, Powis, Park, Liang, Kim: HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer. in Gut 2014
Show all 3 Pubmed References
Human Monoclonal WNT5A Primary Antibody for ELISA, IHC - ABIN4366183
Prgomet, Andersson, Lindberg: Optimization, validation, and identification of two reliable antibodies for immunodetection of WNT5A. in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2017
Human Monoclonal WNT5A Primary Antibody for IHC (p), ELISA - ABIN521385
Thiele, Göbel, Rachner, Fuessel, Froehner, Muders, Baretton, Bernhardt, Jakob, Glüer, Bornhäuser, Rauner, Hofbauer: WNT5A has anti-prostate cancer effects in vitro and reduces tumor growth in the skeleton in vivo. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015
our study showed that, for the first time, different Wnt5a mRNA isoforms play distinct roles in colorectal cancer (CRC (show CALR Antibodies)) and can be used as novel prognostic markers for CRC (show CALR Antibodies) in the future.
High WNT5a expression is associated with osteoarthritis.
We conclude that in RS, WNT5A missense mutations have dominant neomorphic effects that interfere with the function of the wild-type protein.
RSPO2 (show RSPO2 Antibodies) suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7 (show FZD7 Antibodies)-driven noncanonical Wnt (show WNT2 Antibodies) pathway.
High expression of WNT5A is associated with squamous cell lung carcinoma.
Study shows that WNT5A stimulates dimerization of membrane-anchored FZD4 (show FZD4 Antibodies) CRDs and oligomerization of full-length FZD4 (show FZD4 Antibodies), which requires the integrity of CRD (show CRX Antibodies) palmitoleoyl-binding residues. These results suggest that FZD receptors may form signalosomes in response to Wnt (show WNT2 Antibodies) binding through the CRDs and that the Wnt (show WNT2 Antibodies) palmitoleoyl group is important in promoting these interactions.
Taken together with our previous findings, we have replicated our results from the rodent system in a novel human system. We have revealed a unique sequential cascade involving Atg10 (show ATG10 Antibodies), Wnt5a, alpha1 integrin (show ITGA1 Antibodies), and matrix metalloproteinase-3 (show MMP3 Antibodies) in GS/BMP-4 (show BMP4 Antibodies)-induced differentiation of hiPS cells into odontoblast-like cells at a relatively early stage.
Elevated WNT5A expression in obesity may function as a negative regulator of angiogenesis.NEW & NOTEWORTHY Wingless-related integration site 5a (WNT5A) negatively regulates adipose tissue angiogenesis via VEGF-A165b in human obesity.
Wnt5a as a master regulator of brain invasion, specifically tumor-promoting stem-like characteristics (TPC (show CCDC6 Antibodies)), and they provide a therapeutic rationale to target it in patients with glioblastoma.
inhibition of WNT-5A in vivo attenuated lung tissue destruction, improved lung function, and restored expression of beta-catenin (show CTNNB1 Antibodies)-driven target genes and alveolar epithelial cell markers in the elastase, as well as in cigarette smoke induced models of COPD (show ARCN1 Antibodies).
In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a (show WNT3A Antibodies), acted across many cell diameters to orient Prickle3 (show PRICKLE3 Antibodies)/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (show ROR2 Antibodies), which require Wnt5a/Ror2 (show ROR2 Antibodies) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (show PCDH8 Antibodies) signaling via RhoA (show RHOA Antibodies) and Wnt5a/Ror2 (show ROR2 Antibodies) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (show RSPO3 Antibodies) binds syndecan 4 and that together they activate Wnt5a/PCP (show PRCP Antibodies) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (show SDC4 Antibodies) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (show PCDH8 Antibodies) by XWnt-5A requires the receptor tyrosine kinase Ror2 (show ROR2 Antibodies).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (show WNT2 Antibodies)/JNK (show MAPK8 Antibodies) signaling
WNT5A is a negative regulator of FSH (show BRD2 Antibodies)-stimulated granulosa cell steroidogenesis in cattle.
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
results indicate that Wnt5a signaling restricts infection by antimony drug-sensitive and -resistant Leishmania donovani strains, at least in part by prohibiting parasite niche formation within host macrophages
During mouse embryonic stem cell (ESC) in vitro osteogenesis, the noncanonical WNT5a is expressed early on.
This study shows that Wnt5a is not required for development of the renal medulla and that loss of the renal medullary region in the Wnt5a-deleted kidney is caused by an abnormal ureter-bladder connection.
WNT5A in the bone marrow niche is required to regenerate hematopoietic stem cells and leukemic cells with functional ability to rearrange the actin cytoskeleton and engraft successfully.
This study describes the localization and functional role of WNT-5A in human and mouse fibrotic livers. Hepatic WNT-5A expression parallels collagen type I expression. In vivo and in vitro, the myofibroblasts were identified as the key hepatic cells producing WNT-5A. WNT-5A is under control of TGF-beta (show TGFB1 Antibodies) and its activities are primarily profibrotic.
we confirmed the requirement of Wnt5a in the deferoxamine-mediated osteoblast-promoting effects by analyzing the matrix mineralization of Wnt5a-deficient cells. The promoting effect of deferoxamine on matrix mineralization in wild-type cells was completely abolished in Wnt5a(-/-) cells.
opposing gradients of Wnt5a and Wnt5b (show WNT5B Antibodies) and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
Wnt5a is responsible for maintaining effective communication between the stromal and epithelial compartments partly through the action of luminal and stromal secreted factors, Fgf10 (show FGF10 Antibodies) and Ihh (show IHH Antibodies).
findings reveal that FZD9 and heterotrimeric G proteins regulate Wnt-5a signaling and dendritic spines in cultured hippocampal neurons.
Here we show that an evolutionarily conserved genomic region named AS3_9 comprises three TEs (show TES Antibodies) (AmnSINE1, X6b_DNA and MER117), inserted side-by-side, and functions as a distal enhancer for wnt5a expression during morphogenesis of the mammalian secondary palate.
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
, protein Wnt-5a
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A
, wingless-type MMTV integration site family, member 5A
, protein Wnt-5a-like
, cell signaling molecule Wnt-5