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anti-Human WNT5A Antibodies:
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Cow (Bovine) Polyclonal WNT5A Primary Antibody for IHC, IHC (p) - ABIN4366188
Rao, Liu, Zhou, Ma, Lu, Zhou: Expression analysis of Wnt-5a in renal epithelial neoplasms: distinguishing renal oncocytoma from a wide spectrum of renal cell carcinomas. in Tumori 2010
Show all 9 Pubmed References
Human Monoclonal WNT5A Primary Antibody for ICC, IHC - ABIN969460
Dai, Hall, Escara-Wilke, Mizokami, Keller, Keller: Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms. in Cancer research 2008
Show all 2 Pubmed References
Human Monoclonal WNT5A Primary Antibody for IHC, ELISA - ABIN969461
Ford, Ekström, Andersson: Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 2 Pubmed References
Human Monoclonal WNT5A Primary Antibody for IF, IHC - ABIN967259
Martino, Olsen, Fulcher, Wolfgang, ONeal, Ribeiro: Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1. in The Journal of biological chemistry 2009
Show all 3 Pubmed References
Dog (Canine) Polyclonal WNT5A Primary Antibody for IF (p), IHC (p) - ABIN675758
Król, Mucha, Majchrzak, Homa, Bulkowska, Majewska, Gajewska, Pietrzak, Perszko, Romanowska, Paw?owski, Manuali, Hellmen, Motyl: Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors. in PLoS ONE 2014
Show all 2 Pubmed References
Human Monoclonal WNT5A Primary Antibody for IHC (p), ELISA - ABIN521385
Thiele, Göbel, Rachner, Fuessel, Froehner, Muders, Baretton, Bernhardt, Jakob, Glüer, Bornhäuser, Rauner, Hofbauer: WNT5A has anti-prostate cancer effects in vitro and reduces tumor growth in the skeleton in vivo. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015
Human Monoclonal WNT5A Primary Antibody for ELISA, IHC - ABIN4366183
Prgomet, Andersson, Lindberg: Optimization, validation, and identification of two reliable antibodies for immunodetection of WNT5A. in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2017
Human Monoclonal WNT5A Primary Antibody for ELISA, ICC - ABIN2869402
Chang, Nam, Kook, Kim, Liu, Yao, Jung, Lemos, Seo, Park, Gim, Hong, Huh, Kim, Tan, Liu, Powis, Park, Liang, Kim: HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer. in Gut 2014
Show all 3 Pubmed References
WNT5A and IL-6 (show IL6 Antibodies) are connected through a positive feedback loop in melanoma cells
this study reveals that 14-3-3zeta (show YWHAZ Antibodies) plays a critical role in Wnt5a/ROR1 (show ROR1 Antibodies) signaling, leading to enhanced CLL migration and proliferation.
these studies indicate HS1 (show EEF1A2 Antibodies) plays an important role in ROR1 (show ROR1 Antibodies)-dependent Wnt5a-enhanced chemokine (show CCL1 Antibodies)-directed leukemia-cell migration.
Study reports that WNT5A bi-directionally regulates epithelial-mesenchymal transition (EMT (show ITK Antibodies)) in mammary epithelial cells, thereby affecting their migration and invasion. However, the ability of WNT5A to inhibit breast cancer cell migration and invasion is an EMT (show ITK Antibodies)-independent mechanism that, at least in part, can be explained by decreased CD44 (show CD44 Antibodies) expression.
disruption of trans-spliced noncoding RNA RMST expression in human embryonic stem cells results in the upregulation of WNT5A, epithelial-to-mesenchymal transition, and lineage-specific genes/markers.
Wnt5a suppressed osteoblastic differentiation through Ror2 (show ROR2 Antibodies)/JNK (show MAPK8 Antibodies) signaling in periodontal ligament stem cell-like cells.
Genetic blockade of autophagy indicated an unexpected feedback loop whereby knocking down the autophagy factor ATG5 (show ATG5 Antibodies) in Wnt5A(high) cells decreased Wnt5A and increased beta-catenin (show CTNNB1 Antibodies).
Low WNT5A expression is associated with prostate cancer.
WNT5A signaling regulates 15-PGDH (show HPGD Antibodies) expression.
our study showed that, for the first time, different Wnt5a mRNA isoforms play distinct roles in colorectal cancer (CRC (show CALR Antibodies)) and can be used as novel prognostic markers for CRC (show CALR Antibodies) in the future.
In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a (show WNT3A Antibodies), acted across many cell diameters to orient Prickle3 (show PRICKLE3 Antibodies)/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (show ROR2 Antibodies), which require Wnt5a/Ror2 (show ROR2 Antibodies) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (show PCDH8 Antibodies) signaling via RhoA (show RHOA Antibodies) and Wnt5a/Ror2 (show ROR2 Antibodies) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (show RSPO3 Antibodies) binds syndecan 4 and that together they activate Wnt5a/PCP (show PRCP Antibodies) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (show SDC4 Antibodies) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (show PCDH8 Antibodies) by XWnt-5A requires the receptor tyrosine kinase Ror2 (show ROR2 Antibodies).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (show WNT2 Antibodies)/JNK (show MAPK8 Antibodies) signaling
WNT5A is a negative regulator of FSH (show BRD2 Antibodies)-stimulated granulosa cell steroidogenesis in cattle.
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
WNT5A promoted spermatogonial stem cells activity both in vitro and in vivo.
results indicate that Wnt5a signaling restricts infection by antimony drug-sensitive and -resistant Leishmania donovani strains, at least in part by prohibiting parasite niche formation within host macrophages
During mouse embryonic stem cell (ESC) in vitro osteogenesis, the noncanonical WNT5a is expressed early on.
This study shows that Wnt5a is not required for development of the renal medulla and that loss of the renal medullary region in the Wnt5a-deleted kidney is caused by an abnormal ureter-bladder connection.
WNT5A in the bone marrow niche is required to regenerate hematopoietic stem cells and leukemic cells with functional ability to rearrange the actin cytoskeleton and engraft successfully.
This study describes the localization and functional role of WNT-5A in human and mouse fibrotic livers. Hepatic WNT-5A expression parallels collagen type I expression. In vivo and in vitro, the myofibroblasts were identified as the key hepatic cells producing WNT-5A. WNT-5A is under control of TGF-beta (show TGFB1 Antibodies) and its activities are primarily profibrotic.
we confirmed the requirement of Wnt5a in the deferoxamine-mediated osteoblast-promoting effects by analyzing the matrix mineralization of Wnt5a-deficient cells. The promoting effect of deferoxamine on matrix mineralization in wild-type cells was completely abolished in Wnt5a(-/-) cells.
opposing gradients of Wnt5a and Wnt5b (show WNT5B Antibodies) and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
Wnt5a is responsible for maintaining effective communication between the stromal and epithelial compartments partly through the action of luminal and stromal secreted factors, Fgf10 (show FGF10 Antibodies) and Ihh (show IHH Antibodies).
findings reveal that FZD9 and heterotrimeric G proteins regulate Wnt-5a signaling and dendritic spines in cultured hippocampal neurons.
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
, protein Wnt-5a
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A
, wingless-type MMTV integration site family, member 5A
, protein Wnt-5a-like
, cell signaling molecule Wnt-5