WNT5A antibody (AA 62-380)
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- Target See all WNT5A Antibodies
- WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A))
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Binding Specificity
- AA 62-380
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This WNT5A antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
- Cross-Reactivity
- Human, Mouse
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Protein Wnt-5a protein (62-380AA)
- Isotype
- IgG
- Top Product
- Discover our top product WNT5A Primary Antibody
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- Application Notes
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A))
- Alternative Name
- WNT5A (WNT5A Products)
- Synonyms
- hWNT5A antibody, wnt-5A antibody, wnt5a-B antibody, WNT5A antibody, 8030457G12Rik antibody, Wnt-5a antibody, Wnt family member 5A antibody, Wnt family member 5A S homeolog antibody, wingless-type MMTV integration site family, member 5a antibody, wingless-type MMTV integration site family, member 5A antibody, wingless-related MMTV integration site 5A antibody, Wnt signaling ligand antibody, WNT5A antibody, Wnt5a antibody, wnt5a.S antibody, wnt5a antibody, LOC578814 antibody, wnt5 antibody
- Background
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Background: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
Aliases: hWNT 5A antibody, hWNT5A antibody, Protein Wnt 5a antibody, Protein Wnt-5a antibody, Protein Wnt5a antibody, Wingless type MMTV integration site family member 5A antibody, Wnt 5a antibody, WNT 5A protein antibody, WNT 5A protein precursor antibody, WNT5A antibody, WNT5A protein precursor antibody, WNT5A_HUMAN antibody
- UniProt
- P41221
- Pathways
- WNT Signaling, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Cell Size, Tube Formation
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