anti-5'-Nucleotidase, Cytosolic II (NT5C2) Antibodies

NT5C2 encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. Additionally we are shipping 5'-Nucleotidase, Cytosolic II Proteins (11) and 5'-Nucleotidase, Cytosolic II Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NT5C2 22978 P49902
NT5C2 76952 Q3V1L4
NT5C2 100363253  
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Top anti-5'-Nucleotidase, Cytosolic II Antibodies at antibodies-online.com

Showing 10 out of 62 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis in WiDr cell line lysates (35ug/lane) using NT5C2 Antibody . This demonstrates the NT5C2 antibody detected the NT5C2 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to NT5C2 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] Western Blot analysis of NT5C2 expression in transfected 293T cell line by NT5C2 monoclonal antibody (M02), clone 3C1.Lane 1: NT5C2 transfected lysate(64.97 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample(30 ug whole cell lysate) A:H1299 B:HeLa S3, 7.5% SDS PAGE antibody diluted at 1:1000 WB Image Sample (50 ug of whole cell lysate) A: mouse liver 7.5% SDS PAGE antibody diluted at 1:500 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated WB NT5C2 Antibody (N-term) (ABIN656169) western blot analysis in WiDr cell line lysates (35 µg/lane). This demonstrates the NT5C2 antibody detected the NT5C2 protein (arrow). 400 μL 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis NT5C2 using NIH-3T3 whole cell lysates ABIN6279343 at 1/100 staining Human prostate tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat pancreas tissue labeled with Anti-NT5C2 Polyclonal Antibody, Unconjugated (ABIN739353) onjugated 100 μL 3 to 7 Days
$329.45
Details
Human Mouse Un-conjugated ELISA, IF, IHC, IHC (p), WB 100 μg 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of GMPR using rabbit polyclonal GMPR Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GMPR gene. GMPR Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB   100 μL 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testis with NT5C2 polyclonal antibody  shows cytoplasmic positivity in seminiferous duct cells at 1:20-1:50 dilution. 100 μL 11 to 12 Days
$577.33
Details

Top referenced anti-5'-Nucleotidase, Cytosolic II Antibodies

  1. Human Monoclonal NT5C2 Primary Antibody for IF, IHC (p) - ABIN524900 : Kulkarni, Karlsson, Szekeres, Chibalin, Krook, Zierath: Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. in The Journal of biological chemistry 2011 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal NT5C2 Primary Antibody for IF (p), IHC (p) - ABIN739353 : Long, Qiu, Liu, Fei, Feng, Wang, Zhong, Yi, Liu, Zhang, Han: Functional recovery and neuronal regeneration of a rat model of epilepsy by transplantation of Hes1-down regulated bone marrow stromal cells. in Neuroscience 2012 (PubMed)

More Antibodies against 5'-Nucleotidase, Cytosolic II Interaction Partners

Human 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. Targeted sequencing of NT5C2 did not identify any missense variants associated with rs72846714 or wmEry-TGN/wmDNA-TG.

  2. Results uncover dynamic mechanisms of enzyme regulation targeted by chemotherapy resistance-driving NT5C2 mutations in relapsed acute lymphoblastic leukemia.

  3. intersubunit interaction forms structural basis of hyperactive NT5C2 in drug-resistant leukemia in which heterozygous NT5C2 mutation gave rise to hetero-tetramer mutant and WT proteins.

  4. NT5C2 mutations seem to have a broad clinical spectrum and should be sought in patients manifesting either as uncomplicated or complicated spastic paraplegia

  5. Using data from a large-scale genome-wide association study of schizophrenia, study identified several potentially functional variants relating to miRNA function with our top finding being a schizophrenia protective allele that disrupts miR-206s binding to NT5C2 thus leading to increased expression of this gene.

  6. acute lymphoblastic leukemia-specific mutations affect regulation of cN-II

  7. this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus

  8. NT5C2 variant rs11191580 conferred susceptibility to schizophrenia and affected the clinical symptoms of schizophrenia in a South Chinese Han population.

  9. The aberrantly spliced NT5C2 showed substantial reduction in expression level in the in-vitro study, indicating marked instability of the mutant NT5C2 protein.

  10. Leukemia Relapse-Associated Mutation of NT5C2 Gene is Rare in de Novo Acute Leukemias and Solid Tumors.

  11. cN-II co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf lacking the LRR domain.

  12. Data indicate that type II cytosolic 5'-nucleotidase (cN-II) exerts a role in nucleotide and drug metabolism and regulating cell survival.

  13. Four novel body mass index-associated loci near the KCNQ1(rs2237892), ALDH2/MYL2 (rs671, rs12229654), ITIH4 (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations.

  14. These results suggest that mutations in NT5C2 are associated with the outgrowth of drug-resistant clones in acute lymphoblastic leukemia

  15. results highlight the prominent role of relapse-specific mutations in NT5C2 as a mechanism of resistance to 6-Mercaptopurine and a genetic driver of relapse in acute lymphoblastic leukemia

  16. analysis of Drosophila and human 7-methyl GMP-specific nucleotidases

  17. Polymorphisms in the CYP17A1 and NT5C2 genes influence a reduction in both visceral and subcutaneous fat mass in Japanese women.

  18. seven high-resolution structures of human cN-II, including a ligand-free form and complexes with various substrates and effectors, were presented.

  19. cN-II has a role in protecting against progression of non-small cell lung cancer

  20. the expression level of cN-II mRNA might be a prognostic factor of high-risk MDS.

Mouse (Murine) 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. The results on muscles from the NT5C knockout mice contradict previous findings where AMP levels and AMPK activity were shown to be modulated by NT5C enzymes.

Cow (Bovine) 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. mutated three residues that mediate interaction in the first activation site (R144, N154, I152) and three in the second (F127, M436 and H428), and found that ApA and ADP interact with the same site, but the sites for ATP and BPG remain uncertain

5'-Nucleotidase, Cytosolic II (NT5C2) Antigen Profile

Protein Summary

This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides.

Gene names and symbols associated with NT5C2

  • 5'-nucleotidase, cytosolic II (NT5C2) antibody
  • 5'-nucleotidase, cytosolic II (nt5c2.L) antibody
  • 5'-nucleotidase, cytosolic II (nt5c2) antibody
  • 5'-nucleotidase, cytosolic IIa (nt5c2a) antibody
  • 5'-nucleotidase, cytosolic II (Nt5c2) antibody
  • 5'-nucleotidase, cytosolic II (surE2) antibody
  • 2010002I23Rik antibody
  • cN-II antibody
  • CnII antibody
  • ENSMUSG00000025039 antibody
  • Gm9751 antibody
  • Gmp antibody
  • Nt5b antibody
  • NT5C2 antibody
  • Pnt5 antibody
  • wu:fc36f11 antibody
  • wu:fc45b10 antibody

Protein level used designations for NT5C2

cytosolic 5'-nucleotidase II , cytosolic purine 5'-nucleotidase , 5'-nucleotidase, cytosolic II , fc36f11 , 5'-nucleotidase (purine), cytosolic type B , IMP-specific 5'-NT , purine 5' nucleotidase , 5'-nucleotidase cytosolic II , cytosolic IMP/GMP-specific 5'-nucleotidase , cytosolic purine 5'-nucleotidase-like

GENE ID SPECIES
477809 Canis lupus familiaris
444729 Xenopus laevis
548490 Xenopus (Silurana) tropicalis
714292 Macaca mulatta
324845 Danio rerio
22978 Homo sapiens
450706 Pan troglodytes
76952 Mus musculus
281951 Bos taurus
423871 Gallus gallus
100172749 Pongo abelii
5808749 Sorangium cellulosum So ce56
100363253 Rattus norvegicus
100402763 Callithrix jacchus
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