ADAM Metallopeptidase Domain 22 (ADAM22) ELISA Kits

ADAM22 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Additionally we are shipping ADAM22 Antibodies (183) and ADAM22 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ADAM22 11496 Q9R1V6
Anti-Rat ADAM22 ADAM22 57033  
ADAM22 53616 Q9P0K1
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Top ADAM22 ELISA Kits at antibodies-online.com

Showing 2 out of 11 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.058 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$736.84
Details
Mouse 0.04 ng/mL n/a   96 Tests Log in to see 15 to 18 Days
$910.56
Details

More ELISA Kits for ADAM22 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase Domain 22 (ADAM22) interaction partners

  1. LGI1 and ADAM22 form an essential synaptic organizing complex that coordinates the maturation of excitatory synapses by regulating the functional incorporation of PSD-95

  2. Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs).

  3. ADAM22 is an axonal component of the Kv1 K+ channel complex that recruits membrane-associated guanylate kinase to juxtaparanodes

  4. ADAM22 is closely involved in the correct functioning of the nervous system.

  5. study identified LGI1 as a specific binding partner of ADAM22 protein from mouse brain, and demonstrated the specific interaction between LGI1 and ADAM22

Human ADAM Metallopeptidase Domain 22 (ADAM22) interaction partners

  1. the LGI1-ADAM22 complex functions as the trans-synaptic machinery for precise synaptic transmission

  2. ADAM22 is critically involved in miR-449a-reduced tamoxifen resistance of estrogen receptor-positive breast cancer cells as a direct target of miR-449a.

  3. these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy

  4. Disruption of LGI1-ADAM22 interaction reduces synaptic AMPA receptors in hippocampal neurons.

  5. Data suggest that ADAM22 plays roles in cell differentiation, cell migration, and resistance to endocrine therapy in breast cancer; ADAM22 may serve as biomarker for poor disease-free survival in breast cancer patients. [REVIEW]

  6. findings suggest that SRC-1 switches steroid-responsive tumors to a steroid-resistant state in which the SRC-1 target gene ADAM22 has a critical role

  7. Mutations in disintegrin domain sequence in ADAM22 gene is associted with reduced LGI4-binding abilities resulting in epilepsy.

  8. Transgenic leucine-rich glioma-inactivated 4 (Lgi4) and transgenic Adam22 proteins are both expressed in Schwann cells as well as in sensory neurons; binding of Lgi4 to axonal Adam22 is required on axons to drive myelin formation.

  9. role for the 14-3-3zeta/ADAM 22 association in the regulation of cell adhesion and related signaling events

  10. demonstrated a functional role for ADAM22/14-3-3 in cell adhesion and spreading

  11. ADAM22, a brain-specific cell surface protein, mediates growth inhibition using an integrin dependent pathway. It is expressed in normal brain but not in high-grade gliomas.

  12. This study indicated ADAM22 gene is probably not a major gene for this epilepsy syndrome.

  13. Differential coding potential of ADAM22 mRNAs.

  14. our results suggest that neither ADAM22 nor any of the three Kv1 channel genes are major causative genes for ADLTE.

  15. The pro domains of ADAMs are expressed as two subdomains. The most N-terminal subdomain (ADAM22-P(N)) was found to be susceptible to proteolysis and was required for folding stability of the second subdomain (ADAM22-P(C)).

ADAM22 Antigen Profile

Antigen Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.

Gene names and symbols associated with ADAM22

  • a disintegrin and metallopeptidase domain 22 (Adam22) antibody
  • ADAM metallopeptidase domain 22 (Adam22) antibody
  • ADAM metallopeptidase domain 22 (ADAM22) antibody
  • ADAM metallopeptidase domain 22 L homeolog (adam22.L) antibody
  • 2900022I03Rik antibody
  • ADAM 22 antibody
  • AI854032 antibody
  • mdc2 antibody
  • mdc11b antibody

Protein level used designations for ADAM22

a disintegrin and metalloprotease domain (ADAM) 22 , disintegrin and metalloproteinase domain-containing protein 22 , a disintegrin and metalloprotease domain 22 , a disintegrin and metalloproteinase domain 22 , metalloproteinase-disintegrin ADAM22-3 , metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2 , ADAM 22 , MDC11.2 , metalloprotease-disintegrin MDC11b , metalloprotease/disintegrin xMDC11.2

GENE ID SPECIES
11496 Mus musculus
57033 Rattus norvegicus
53616 Homo sapiens
386621 Xenopus laevis
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