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ADAM22 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Additionally we are shipping ADAM22 Antibodies (181) and ADAM22 Proteins (9) and many more products for this protein.
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LGI1 (show LGI1 ELISA Kits) and ADAM22 form an essential synaptic organizing complex that coordinates the maturation of excitatory synapses by regulating the functional incorporation of PSD-95 (show DLG4 ELISA Kits)
Interaction proteomics revealed the interactors of Caspr2 (show CNTNAP2 ELISA Kits), including CNTN2 (show CNTN2 ELISA Kits), KCNAs, members of the ADAM family (ADAM22, ADAM23 (show Adam23 ELISA Kits) and ADAM11 (show ADAM11 ELISA Kits)), members of LGI family and MAGUKs (DLGs and MPPs (show MPHOSPH6 ELISA Kits)).
ADAM22 is an axonal component of the Kv1 (show KCNA5 ELISA Kits) K+ channel complex that recruits membrane-associated guanylate kinase (show GUK1 ELISA Kits) to juxtaparanodes
ADAM22 is closely involved in the correct functioning of the nervous system.
study identified LGI1 (show LGI1 ELISA Kits) as a specific binding partner of ADAM22 protein from mouse brain, and demonstrated the specific interaction between LGI1 (show LGI1 ELISA Kits) and ADAM22
these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE (show LGI1 ELISA Kits)-causing LGI1 (show LGI1 ELISA Kits) mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 (show LGI1 ELISA Kits) with both ADAM22 and ADAM23 (show Adam23 ELISA Kits) play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy
Disruption of LGI1 (show LGI1 ELISA Kits)-ADAM22 interaction reduces synaptic AMPA (show GRIA3 ELISA Kits) receptors in hippocampal neurons.
Data suggest that ADAM22 plays roles in cell differentiation, cell migration, and resistance to endocrine therapy in breast cancer; ADAM22 may serve as biomarker for poor disease-free survival in breast cancer patients. [REVIEW]
findings suggest that SRC-1 (show SRC ELISA Kits) switches steroid-responsive tumors to a steroid-resistant state in which the SRC-1 (show SRC ELISA Kits) target gene ADAM22 has a critical role
Mutations in disintegrin domain sequence in ADAM22 gene is associted with reduced LGI4-binding abilities resulting in epilepsy.
Transgenic leucine-rich glioma-inactivated 4 (Lgi4) and transgenic Adam22 proteins are both expressed in Schwann cells as well as in sensory neurons; binding of Lgi4 to axonal Adam22 is required on axons to drive myelin formation.
role for the 14-3-3zeta (show YWHAZ ELISA Kits)/ADAM 22 association in the regulation of cell adhesion and related signaling events
demonstrated a functional role for ADAM22/14-3-3 (show YWHAQ ELISA Kits) in cell adhesion and spreading
ADAM22, a brain-specific cell surface protein (show CD28 ELISA Kits), mediates growth inhibition using an integrin dependent pathway. It is expressed in normal brain but not in high-grade gliomas.
This study indicated ADAM22 gene is probably not a major gene for this epilepsy syndrome.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.
a disintegrin and metalloprotease domain (ADAM) 22
, disintegrin and metalloproteinase domain-containing protein 22
, a disintegrin and metalloprotease domain 22
, a disintegrin and metalloproteinase domain 22
, metalloproteinase-disintegrin ADAM22-3
, metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
, ADAM 22
, metalloprotease-disintegrin MDC11b
, metalloprotease/disintegrin xMDC11.2