ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 Proteins (ADAMTS13)

ADAMTS13 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Additionally we are shipping ADAMTS13 Antibodies (91) and ADAMTS13 Kits (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADAMTS13 11093 Q76LX8
ADAMTS13 279028 Q769J6
Rat ADAMTS13 ADAMTS13 102554393  
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Top ADAMTS13 Proteins at antibodies-online.com

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$932.80
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Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human vWFCP Protein. 100 μg 11 to 18 Days
$810.17
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ADAMTS13 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) Interaction Partners

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) interaction partners

  1. relative plasma deficiency of ADAMTS13 activity may be associated with more severe traumatic injury, significant endothelial glycocalyx damage, coagulation abnormalities and mortality after severe trauma in paediatric patients

  2. Low ADAMTS-13 activity is a predictor of unfavourable outcome in patients with ischaemic stroke undergoing endovascular therapy

  3. analysis of ADAMTS13 variants in a patient cohort with Upshaw-Schulman Syndrome investigated in Germany

  4. Through its action on VWF, ADAMTS13 can have prothrombotic and proinflammatory properties, not only when its activity is severely deficient, but also when it is only moderately low.

  5. An open ADAMTS-13 conformation is also a hallmark of acute acquired thrombotic thrombocytopenic purpura, altering autoantibody binding.

  6. truncation of ADAMTS13 by plasmin abolishes intramolecular self-association, which improves interaction with unfolded von Willebrand Factor

  7. antigen and activity both positively correlated with plasma viral load in HIV infection

  8. protein C and ADAMTS-13 change were associated with outcome in an ongoing endothelial/hemostatic disorder was during sepsis

  9. Upshaw-Schulman Syndrome With c.2728C>T Mutation in ADAMTS13 Gene.

  10. ADAMTS13 rs2285489 genotyping in transplant recipients may be a useful tool for evaluating pretransplantation risks.

  11. Genetic analysis of 5 children with congentical thrombotic thrombocytopenia purpura showed complex heterozygous mutations at different loci of ADAMTS13 gene

  12. this study shows that in Upshaw-Schulman syndrome, age-onset defines two entities and ADAMTS13 sequence variations modify ADAMTS13 conformation

  13. acute myeloid leukemia patients with low activity of ADAMTS-13 had worse prognosis after bone morrow transplantation.

  14. The Plasma Levels of ADAMTS-13, von Willebrand Factor, VWFpp, and Fibrin-Related Markers in Patients With Systemic Sclerosis Having Thrombosis

  15. The aim of the study was to investigate the role of von Willebrand factor (vWF), the vWF-cleaving protease, ADAMTS13, the composition of thrombus, and patient outcome following mechanical cerebral artery thrombectomy in patients with acute ischemic stroke.

  16. ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group.

  17. Decreased ADAMTS-13 activity was found in patients with proliferative lupus nephritis, and plasma ADAMTS-13 activity was closely associated with renal injury indices.

  18. These results suggest that highly elevated plasma VWF might accelerate platelet thrombus formation not only in the circulation but also on the surface of vascular endothelial cells in the setting of ADAMTS13 deficiency in Upshaw-Schulman syndrome.

  19. Prothrombotic state and systemic inflammation status might contribute to explaining the high incidence of concealed chronic renal failure in COPD, and plasma ADAMTS-13 levels may serve as a strong predictor.

  20. VWF, GMP-140, ADAMTS13 and the cerebral vasospasm, delayed cerebral ischemia, tumor diameter and prognosis of aneurysmal subarachnoid hemorrhage patients are closely related

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 13 (ADAMTS13) interaction partners

  1. ADAMTS13-vWF axis is partially involved in the pathophysiology of kidney ischemic reperfusion injury.

  2. Adamts13 deficiency in obese mice promotes hepatic microthrombosis.

  3. results suggest that ADAMTS13 controls key steps of ischemic vascular remodeling and that recombinant ADAMTS13 is a putative therapeutic avenue for promoting stroke recovery.

  4. ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF-dependent intrarenal thrombosis.

  5. administration of ADAMTS13 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA patency and consequently reduced cerebral infarct sizes

  6. Sleeping beauty transposon-mediated gene therapy achieved sustained expression of transgene ADAMTS13 and long-term prophylaxis against congenital thrombotic thrombocytopenic purpura in Adamts13(-/-) mice.

  7. Results also suggest that Toxoplasma gondii-mediated apoptosis might play a pivotal role and a different type of role in the mechanism of neurodegeneration and neuropathology in the process of toxoplasma encephalitis. Furthermore, expression of ADAMTS-13 might give an idea of the progress and is critical for diagnosis of this disease.

  8. Letter: deficiency of ADAMTS13 results in increased formation of venous thrombosis in mice.

  9. ADAMTS13 substrate specificity

  10. Data indicate that the p.D187H mutation impairs ADAMTS13 activity and secretion and may contribute to thrombotic thrombocytopenic purpura.

  11. Data show that metalloendopeptidase ADAMTS13 does not directly promote development of adipose tissue.

  12. findings provide further evidence on the pathophysiological role for the ADAMTS13/VWF axis in atherosclerosis

  13. Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.

  14. Three novel mutations in a homozygous state were identified in these patients: c.1308G>C, c.428T>C (p.Ile143Thr) and c.1709A>G (p.Tyr570Cys)

  15. The results indicate that the microvascular process induced by ADAMTS13 deficiency triggers complement activation on platelets and the endothelium, which may contribute to formation of thrombotic microangiopathy.

  16. model of acute myocardial infarction in ADAMTS13 gene deleted (Adamts13 -/-) mice

  17. We hypothesize that ADAMTS13 protects brain from ischemia-reperfusion injury by regulating von Willebrand factor -dependent inflammation as well as microvascular plugging

  18. Cyclophilin B activity regulated secretion and activity of ADAMTS13.

  19. Adamts13(-/-) mice developed larger myocardial infarctions than wild-type control mice.

  20. ADAMTS13 and VWF are causally involved in myocardial ischemia/reperfusion injury.

ADAMTS13 Protein Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Gene names and symbols associated with ADAMTS13

  • ADAM metallopeptidase with thrombospondin type 1 motif 13 (ADAMTS13)
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 (Adamts13)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (adamts13)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (Adamts13)
  • ADAM metallopeptidase with thrombospondin type 1 motif 13 (Adamts13)
  • ADAM-TS13 protein
  • ADAMTS-13 protein
  • ADAMTS13 protein
  • C9orf8 protein
  • Gm710 protein
  • vWF-CP protein
  • VWFCP protein

Protein level used designations for ADAMTS13

ADAM metallopeptidase with thrombospondin type 1 motif, 13 , A disintegrin and metalloproteinase with thrombospondin motifs 13 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 , vWF-cleaving protease , von Willebrand factor-cleaving protease , ADAM-TS 13 , ADAM-TS13 , ADAMTS-13 , ADAMTS13 isoform IAP-b , vWF-CP mRNA for von Willebrand factor-cleaving , ADAM metallopeptidase with thrombospondin type 1 motif, 13 isoform 1 preproprotein-like , A disintegrin and metalloproteinase with thrombospondin motifs 13-like , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

GENE ID SPECIES
100069281 Equus caballus
11093 Homo sapiens
279028 Mus musculus
532272 Bos taurus
100320289 Danio rerio
100404947 Callithrix jacchus
100343027 Oryctolagus cuniculus
100481099 Ailuropoda melanoleuca
100226372 Taeniopygia guttata
100630922 Canis lupus familiaris
102554393 Rattus norvegicus
100727045 Cavia porcellus
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