anti-APC Membrane Recruitment Protein 1 (AMER1) Antibodies

The protein encoded by AMER1 upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Additionally we are shipping APC Membrane Recruitment Protein 1 Kits (2) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
AMER1 72345 Q7TS75
AMER1 139285 Q5JTC6
AMER1 501584  
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Top anti-APC Membrane Recruitment Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Western blot analysis of WTX antibody (Center) in mouse kidney tissue lysates (35ug/lane). WTX (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of WTX antibody in mouse kidney tissue lysates (35ug/lane) WTX Antibody IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$793.83
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Cy5 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Cy7 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Cy5.5 IF (p)   100 μL 14 to 21 Days
$416.90
Details

More Antibodies against APC Membrane Recruitment Protein 1 Interaction Partners

Mouse (Murine) APC Membrane Recruitment Protein 1 (AMER1) interaction partners

  1. analysis provides a novel model for WTX-caused bone diseases and explains on the molecular level how truncation mutations in this gene may retain some of WTX-protein functions.

  2. WTX stabilized chromatin binding by TRIM28 and contributed to transcriptional repression of repetitive sequences by TRIM28 in mouse embryonic stem cells.

  3. The constellation of anomalies in Wtx null mice suggests that this tumor suppressor broadly regulates mesenchymal progenitor cells in multiple tissues.

  4. The observed phenotypic discordance dependent upon whether a mutation is germline or occurs somatically suggests the existence of temporal or spatial constraints on the action of WTX during tumorigenesis.

Human APC Membrane Recruitment Protein 1 (AMER1) interaction partners

  1. This study revealed no clinical or pathologic distinctions between Wilms tumor (WT) with and without WTX mutation. This similarity lends support to the concept of a common tumorigenic pathway between WT with aberrant WTX and those without.

  2. Data suggest that the aberrant upregulation of miR-20a/miR-106a as the reason of Wilms tumor gene on the X chromosome (WTX) loss in colorectal cancer (CRC) both in vivo and in vitro.

  3. A novel heterozygous frameshift mutation in AMER1 was identified in a patient with osteopathia striata with cranial sclerosis.

  4. Losses of AMER1 by other mechanisms apart from mutations.

  5. A nonsense mutation (c.1045C>T, p.Glu349*) in the WTX gene.

  6. Data show that beta-arrestins regulate Wnt3a-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation by the regulation of the membrane dynamics of Amer1.

  7. WTX inactivation occurs in a wider variety of tumor types than previously appreciated and point to shared pathogenic mechanisms between a subset of pediatric malignancies.

  8. Data indicate that osteopathia striata congenita with cranial sclerosis (OSCS) iscaused by germline deletions of in the X-linked gene WTX (FAM123B, AMER1).

  9. Two novel WTX mutations underscore the unpredictability of male survival in osteopathia striata with cranial sclerosis.

  10. Stat3 inhibits WTX expression through up-regulation of micro RNA-370 in Wilms tumor.

  11. Osteopathia striata with cranial sclerosis or Horan-Beighton syndrome is a rare X-linked dominant inherited bone dysplasia. Genetic analysis allowed the identification of maternally transmitted heterozygous nonsense c.1057C>T (p.R353X) WTX mutation.

  12. WTX mutations occur early in Wilms' tumor development, but at a low proportion. There was no evidence that WTX is the main cause of Wilms' tumor.

  13. WTX modulates p53 function, in part through regulation of its activator CBP/p300.

  14. WTX and NRF2 compete for binding to KEAP1, and thus loss of WTX leads to rapid ubiquitination and degradation of NRF2 and a reduced response to cytotoxic insult.

  15. Amer1 exerts its negative regulatory role in Wnt signaling by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the plasma membrane.

  16. WTX mutations can arise both early and late in Wilms tumour development

  17. When gene expression changes mediated by wild-type WTX were compared with those affected by mutant WTX, WTX565 had a 55% overlap in differentially regulated genes, whereas WTX358 regulated only two genes affected by wild-type WTX.

  18. Mutations in the WTX-gene are associated with high-grade microsatellite instable colorectal cancers.

  19. inactivation of WTX appears to be a late event in tumorigenesis of nephroblastoma in a subgroup of nephroblastomas

  20. All investigated families diagnosed with Osteopathia striata with cranial sclerosis had WTX gene defects.

APC Membrane Recruitment Protein 1 (AMER1) Antigen Profile

Protein Summary

The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS).

Gene names and symbols associated with AMER1

  • APC membrane recruitment 1 (Amer1) antibody
  • APC membrane recruitment protein 1 (AMER1) antibody
  • APC membrane recruitment protein 1 (Amer1) antibody
  • APC membrane recruitment protein 1 (amer1) antibody
  • 2810002O09Rik antibody
  • AW492303 antibody
  • fam123b antibody
  • OSCS antibody
  • RGD1560322 antibody
  • WTX antibody

Protein level used designations for AMER1

APC membrane recruitment protein 1 , family with sequence similarity 123, member B , protein Fam123b , Wilms tumor gene on the X chromosome protein , Wilms tumor on the X , adenomatous polyposis coli membrane recruitment 1 , family with sequence similarity 123B , protein FAM123B , APC membrane recruitment 1 , Protein FAM123B , wtx

GENE ID SPECIES
72345 Mus musculus
139285 Homo sapiens
501584 Rattus norvegicus
100885784 Danio rerio
422314 Gallus gallus
539029 Bos taurus
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