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Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by A1CF. Additionally we are shipping A1CF Kits (17) and A1CF Proteins (6) and many more products for this protein.
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Human Polyclonal A1CF Primary Antibody for IF, WB - ABIN526205
Shimizu, Nishitsuji, Marusawa, Ujino, Takaku, Shimotohno: The RNA-editing enzyme APOBEC1 requires heterogeneous nuclear ribonucleoprotein Q isoform 6 for efficient interaction with interleukin-8 mRNA. in The Journal of biological chemistry 2014
Study reported that the deleted 8aa, EIYMNVPV, was just localized in the internal region of A1CF nuclear translocation signal. Also, A1CF (-8aa), but not its full-length counterpart, can promote proliferation of MDA-MB-231 cells accompanied with increased level of IL-6 (show IL6 Antibodies) mRNA.
hnRNP K (show HNRNPK Antibodies) and hnRNP L (show HNRNPL Antibodies) may serve as A1CF-like cofactors in AID-mediated class switch recombination and somatic hypermutation
The data presented in this report suggested that similar regulatory mechanisms controlling the functional interaction of APOBEC-1 (show APOBEC1 Antibodies) with ACF might be operational during enterocyte differentiation.
results suggested both AID and APOBEC-1 (show APOBEC1 Antibodies) are equally likely to bind single-stranded DNA or RNA, which has implications for the identification of natural AID targets
ACF plays a crucial role, which is independent of apobec-1 (show APOBEC1 Antibodies) expression, in cell survival, particularly during early embryonic development
Here, we show that partial loss of either APOBEC1 complementation factor (A1CF), the RNA-binding cofactor of APOBEC1 (show APOBEC1 Antibodies) in RNA editing, or Argonaute 2 (AGO2 (show EIF2C2 Antibodies)), a key factor in the biogenesis of certain noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and conventional genetic manners.
The observations demonstrate that A1CF does not act as the APOBEC1 complementation factor in vivo under normal physiological conditions and suggest new roles for A1CF, specifically within the male adult kidney.
Data show that the importance of ACF for modulating ApoB (show APOB Antibodies) was supported by the finding that RNAi knockdown of ACF reduced ApoB (show APOB Antibodies) secretion.
ACF regulates liver regeneration following partial hepatectomy at least in part by controlling the stability of IL-6 (show IL6 Antibodies) mRNA
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene.
APOBEC-1 stimulating protein
, apo-B RNA editing protein
, apobec-1 complementation factor (ACF) (ASP)
, APOBEC1-stimulating protein
, apobec-1 complementation factor
, APOBEC1 complementation factort
, Apobec-1 complementation factor APOBEC-1 stimulating protein
, Apobec-1 complementation factor, APOBEC-1 stimulating protein
, APOBEC1 complementation factor