anti-APOBEC1 Complementation Factor (A1CF) Antibodies

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by A1CF. Additionally we are shipping A1CF Kits (20) and A1CF Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
A1CF 29974 Q9NQ94
A1CF 69865 Q5YD48
A1CF 170912 Q923K9
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Top anti-A1CF Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-A1CF Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: HepG2 cell lysate A1CF is supported by BioGPS gene expression data to be expressed in HepG2 Host: Rabbit Target Name: A1CF Sample Type: Human Adult Placenta Antibody Dilution: 1.0ug/ml 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-A1CF Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Spleen 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB ACF Antibody (C-term) (ABIN654627) flow cytometric analysis of A375 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB ACF Antibody (C-term) flow cytometric analysis of A375 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. ACF Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ACF Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL 6 to 8 Days
$484.00
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of A1CF expression in transfected 293T cell line by A1CF MaxPab polyclonal antibody.Lane 1: ACF transfected lysate(65.34 KDa).Lane 2: Non-transfected lysate. ACF MaxPab polyclonal antibody. Western Blot analysis of ACF expression in human placenta. 50 μL 11 to 12 Days
$440.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$581.17
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Porcine Liver Tissue; Lane2: Human Hela Cells; Lane3: Human Jurkat Cells; Lane4: Human 293T Cells. 100 μg 15 to 18 Days
$314.00
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-A1CF / ACF antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μL 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated WB A1CF antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Details

Top referenced anti-A1CF Antibodies

  1. Human Polyclonal A1CF Primary Antibody for IF, WB - ABIN526205 : Shimizu, Nishitsuji, Marusawa, Ujino, Takaku, Shimotohno: The RNA-editing enzyme APOBEC1 requires heterogeneous nuclear ribonucleoprotein Q isoform 6 for efficient interaction with interleukin-8 mRNA. in The Journal of biological chemistry 2014 (PubMed)

More Antibodies against A1CF Interaction Partners

Human APOBEC1 Complementation Factor (A1CF) interaction partners

  1. A1CF-Axin2 signal axis regulates Wilms tumor-derived cells' apoptosis and migration through Axin2.

  2. Interaction of any alcohol exposure with GCKR (rs780094) and A1CF (rs10821905) influenced the risk of gout in Europeans

  3. Study reported that the deleted 8aa, EIYMNVPV, was just localized in the internal region of A1CF nuclear translocation signal. Also, A1CF (-8aa), but not its full-length counterpart, can promote proliferation of MDA-MB-231 cells accompanied with increased level of IL-6 mRNA.

  4. hnRNP K and hnRNP L may serve as A1CF-like cofactors in AID-mediated class switch recombination and somatic hypermutation

  5. The data presented in this report suggested that similar regulatory mechanisms controlling the functional interaction of APOBEC-1 with ACF might be operational during enterocyte differentiation.

  6. results suggested both AID and APOBEC-1 are equally likely to bind single-stranded DNA or RNA, which has implications for the identification of natural AID targets

  7. ACF plays a crucial role, which is independent of apobec-1 expression, in cell survival, particularly during early embryonic development

Mouse (Murine) APOBEC1 Complementation Factor (A1CF) interaction partners

  1. A1CF and RBM47 each function independently, yet interact in a tissue-specific manner, to regulate the activity and site selection of APOBEC1 dependent C-to-U RNA editing.

  2. Here, we show that partial loss of either APOBEC1 complementation factor (A1CF), the RNA-binding cofactor of APOBEC1 in RNA editing, or Argonaute 2 (AGO2), a key factor in the biogenesis of certain noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and conventional genetic manners.

  3. The observations demonstrate that A1CF does not act as the APOBEC1 complementation factor in vivo under normal physiological conditions and suggest new roles for A1CF, specifically within the male adult kidney.

  4. Data show that the importance of ACF for modulating ApoB was supported by the finding that RNAi knockdown of ACF reduced ApoB secretion.

  5. ACF regulates liver regeneration following partial hepatectomy at least in part by controlling the stability of IL-6 mRNA

  6. ACF plays a crucial role, which is independent of apobec-1 expression, in cell survival, particularly during early embryonic development

A1CF Antigen Profile

Protein Summary

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with A1CF

  • APOBEC1 complementation factor (A1CF) antibody
  • APOBEC1 complementation factor (A1cf) antibody
  • apobec1 complementation factor (a1cf) antibody
  • APOBEC1 complementation factor L homeolog (a1cf.L) antibody
  • APOBEC1 complementation factor (a1cf) antibody
  • 1810073H04Rik antibody
  • A1CF antibody
  • A1cft antibody
  • acf antibody
  • acf64 antibody
  • acf65 antibody
  • Apobec-1 antibody
  • apobec1cf antibody
  • asp antibody

Protein level used designations for A1CF

APOBEC-1 stimulating protein , apo-B RNA editing protein , apobec-1 complementation factor (ACF) (ASP) , APOBEC1-stimulating protein , apobec-1 complementation factor , APOBEC1 complementation factort , Apobec-1 complementation factor APOBEC-1 stimulating protein , Apobec-1 complementation factor, APOBEC-1 stimulating protein , acf , APOBEC1 complementation factor

GENE ID SPECIES
29974 Homo sapiens
69865 Mus musculus
170912 Rattus norvegicus
423680 Gallus gallus
477581 Canis lupus familiaris
562916 Danio rerio
100174508 Pongo abelii
100339264 Oryctolagus cuniculus
444478 Xenopus laevis
703806 Macaca mulatta
100493284 Xenopus (Silurana) tropicalis
100540486 Meleagris gallopavo
100553455 Anolis carolinensis
100600191 Nomascus leucogenys
100336715 Bos taurus
100155074 Sus scrofa
100730935 Cavia porcellus
101118147 Ovis aries
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