ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1A Proteins (ABCB1A)

The membrane-associated protein encoded by ABCB1A is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ABCB1A ABCB1A 170913  
ABCB1A 18671 P21447
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1A Proteins at

Showing 2 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 70 to 75 Days

ABCB1A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1A (ABCB1A) Interaction Partners

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1A (ABCB1A) interaction partners

  1. A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates.

  2. The results of this study suggested suggest that THC exposure decreased the neurobehavioral effects of risperidone because of P-gp upregulation in the brain.

  3. The results show that the absence of P-gp results in a significant disturbance of Abeta removal from the brain and increased intraparenchymal cerebral amyloid angiopathy after immunization against Beta-Amyloid.

  4. These data confirm that seliciclib displays a limited brain exposure and Abcb1a is at least partly responsible for limited brain exposure of seliciclib in mice.

  5. Data suggest that, in the presence of verapamil (a substrate that activates ATP hydrolysis), the nucleotide-binding domains of Abcb1a (reconstituted in lipid bilayer nanodiscs) are never far apart during cycle of ATP hydrolysis.

  6. Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding have been reported.

  7. MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis.

  8. multiple pathways, including MMP9 cleavage and ubiquitinylation, mediated P-gp downmodulation.

  9. Data suggest that MDR3 isoforms, both human and mouse isoforms, exhibit different affinities for fluorescent dyes and drugs; thus, ligands likely occupy partially overlapping but distinct binding sites.

  10. using double electron-electron resonance and molecular dynamics simulations to describe the ATP- and substrate-coupled conformational cycle of the mouse ABC efflux transporter P-glycoprotein (Pgp; also known as ABCB1)

  11. Mdr1a deficiency significantly enhanced the analgesic effect of aconitine and exacerbated its toxicity in the brain.

  12. Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.

  13. Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.

  14. These results indicate that nilotinib reverses P-gp- mediated MDR by blocking the efflux function and potentiates DOX-induced cardiotoxicity.

  15. Results indicate that Abeta accumulates to a greater degree in brains of mice lacking MDR1A

  16. [(18)F]Mefway is modulated by P-gp, and not by Bcrp in rodents.

  17. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  18. Analysis regulator effects analysis, showed that curcumin's antiinflammatory activity in Mdr1a(-/-) mouse colon may be mediated by activation of alpha-catenin, which has not previously been reported

  19. mdr1a-siRNA mediated inhibition of Mdr1a expression markedly elevates serum levels and increases the hepatic exposure to triptolide.

  20. Data suggest that activities of human ABCB1 and mouse Abcb1a/Mdr1a are unaltered (that is, efflux of fluorescent dyes is unaltered) in chimeric forms created by exchange of homologous transmembrane/nucleotide-binding domains of ABCB1 and Abcb1a/Mdr1a.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1A (ABCB1A) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs.

Gene names and symbols associated with ABCB1A

  • ATP binding cassette subfamily B member 1A (Abcb1a)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1A (Abcb1a)
  • Abcb1 protein
  • Abcb4 protein
  • Evi32 protein
  • mdr-3 protein
  • Mdr1a protein
  • Mdr3 protein
  • P-gp protein
  • Pgp protein
  • Pgy-3 protein
  • Pgy3 protein

Protein level used designations for ABCB1A

ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , ATP-binding cassette sub-family B member 1A , ATP-binding cassette, sub-family B (MDR/TAP), member 4 , ATP-binding cassette, subfamily B, member 1A , P glycoprotein 3 , P-glycoprotein 3 , ecotropic viral integration site 32 , multi-drug resistance 3 , multidrug resistance protein 1A , multidrug resistance protein 3

170913 Rattus norvegicus
18671 Mus musculus
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