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The protein encoded by ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC4 Antibodies (169) and ABCC4 Proteins (3) and many more products for this protein.
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MRP4 is a functional prostaglandin carrier under the regulation of oxytocin in the bovine endometrium.
This study provides direct evidence that ganciclovir (GCV) is a substrate of the efflux transporter MRP4 and suggests that the intracellular fate of GCV is significantly influenced by ABCC4 rs11568658 variant in renal transplant recipients receiving GCV
Multidrug resistance protein 4 (MRP4) is a critical protein associated with the antiviral efficacy of nucleos(t)ide analogue (NA)s, and combination therapy of NA and MRP inhibitors could reduce the dosage for long-term NA use. MRP4 expression is an important factor predicting treatment failure in chronic hepatitis B patients and will provide a potential therapeutic target against hepatitis B virus.
All patients with both NUDT15 rs116855232 heterozygous variants and ABCC4 rs3765534 variants suffered from severe leukopenia and required 6-mercaptopurine dose reduction to less than 35 mg/m(2)/da
ABCC4 variant (rs4148500) was significantly associated with hyperuricemia and gout. The gout risk allele was associated with fractional excretion of uric acid in male individuals.
ABCC4 functional SNP in the 3' splice acceptor site of exon 8 (G912T) is associated with unfavorable clinical outcome in children with acute lymphoblastic leukemia
Data suggest that common SNPs in MRP4/ABCC4 (evaluated here via site-directed mutagenesis in recombinant proteins expressed in kidney cell lines) are responsible for variations in transport of methylated arsenic metabolites (major urinary arsenic metabolites in humans), prostaglandin E2, and estradiol-17 beta-glucuronide.
Data indicate that R-flurbiprofen inhibits multidrug resistance-associated protein 4 (MRP4, ABCC4)-mediated prostaglandins (PG) transport.
Analysis of gene-gene interactions with CYP2B6 (show CYP2B6 ELISA Kits) was particularly useful to reinforce the role of MRP4 and to reveal unknown associations, such as that of DRD3 (show DRD3 ELISA Kits).
The tagSNP ABCC4 rs17268122 appears to be a prognostic factor in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) and surgery, independently of response to nCRT
ABCC4 plays a protective role against cytarabine-mediated insults in leukemic and host myeloid cells.
The diversity at N-termini in these protein isoforms explains the diverse function of ABCC4 in mouse.
P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier
These findings have important clinical implications because they directly highlight an important relationship between ABCC4 transporter function and phosphodiesterases in accounting for the cAMP-directed activity of antithrombotic agents.
A novel cAMP-dependent mechanism for MRP4-mediated regulation of fibroblast migration and indicated that PKA and actin play important roles as downstream effectors.
Loss of MRP4 is associated with impaired platelet activation and cAMP homeostasis
Upregulation of COX-2 in lung cancer promotes overexpression of MRP4 via PGE2-dependent pathway
role of MRP4 in thrombus formation
NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.
Abcc4 in the stomach facilitates the oral absorption of dasatinib, and it possibly plays a similar role for other orally administered substrates, such as acetylsalicylic acid.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined\; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.
multidrug resistance-associated protein 4
, ATP-binding cassette, sub-family C (CFTR/MRP), member 4
, ATP-binding cassette protein C4-like
, multidrug resistance-associated protein 4-like
, ATP-binding cassette sub-family C member 4
, MRP/cMOAT-related ABC transporter
, bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)
, canalicular multispecific organic anion transporter (ABC superfamily)
, multi-specific organic anion transporter B
, multispecific organic anion transporter B
, ATP-binding cassette protein C4