ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) ELISA Kits

The protein encoded by ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human ABCC4 ABCC4 10257 O15439
Anti-Mouse ABCC4 ABCC4 239273  
Anti-Rat ABCC4 ABCC4 170924  
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Top ABCC4 ELISA Kits at antibodies-online.com

Showing 2 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.133 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13 to 16 Days
$736.84
Details
Human < 0.115 ng/mL 0.312 ng/mL - 20 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details

More ELISA Kits for ABCC4 Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) interaction partners

  1. A functional polymorphism in the ABCC4 promoter, -1508A>G, may increase extracellular 15-hydroxyeicosatetraenoic acid, sphingosine-1-phosphate, and periostin (show POSTN ELISA Kits) levels, contributing to airway inflammation in asthmatics.

  2. MRP4 localisation and function are regulated by interactions with SNX27, PSD95 (show DLG4 ELISA Kits), and AP3B1 (show AP3B1 ELISA Kits).

  3. MRP4 exports prostaglandin E2 PGE2 and contributes to cell migration/metastasis in basal/triple negative breast cancer cells.

  4. This study provides direct evidence that ganciclovir (GCV) is a substrate of the efflux transporter MRP4 and suggests that the intracellular fate of GCV is significantly influenced by ABCC4 rs11568658 variant in renal transplant recipients receiving GCV

  5. Multidrug resistance protein 4 (MRP4) is a critical protein associated with the antiviral efficacy of nucleos(t)ide analogue (NA)s, and combination therapy of NA and MRP inhibitors could reduce the dosage for long-term NA use. MRP4 expression is an important factor predicting treatment failure in chronic hepatitis B patients and will provide a potential therapeutic target against hepatitis B virus.

  6. All patients with both NUDT15 rs116855232 heterozygous variants and ABCC4 rs3765534 variants suffered from severe leukopenia and required 6-mercaptopurine dose reduction to less than 35 mg/m(2)/da

  7. ABCC4 variant (rs4148500) was significantly associated with hyperuricemia and gout. The gout risk allele was associated with fractional excretion of uric acid in male individuals.

  8. ABCC4 functional SNP in the 3' splice acceptor site of exon 8 (G912T) is associated with unfavorable clinical outcome in children with acute lymphoblastic leukemia

  9. Data suggest that common SNPs in MRP4/ABCC4 (evaluated here via site-directed mutagenesis in recombinant proteins expressed in kidney cell lines) are responsible for variations in transport of methylated arsenic metabolites (major urinary arsenic metabolites in humans), prostaglandin E2, and estradiol-17 beta-glucuronide.

  10. Data indicate that R-flurbiprofen inhibits multidrug resistance-associated protein 4 (MRP4, ABCC4)-mediated prostaglandins (PG) transport.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) interaction partners

  1. The diversity at N-termini in these protein isoforms explains the diverse function of ABCC4 in mouse.

  2. ABCC4 plays a protective role against cytarabine-mediated insults in leukemic and host myeloid cells.

  3. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  4. These findings have important clinical implications because they directly highlight an important relationship between ABCC4 transporter function and phosphodiesterases in accounting for the cAMP-directed activity of antithrombotic agents.

  5. A novel cAMP-dependent mechanism for MRP4-mediated regulation of fibroblast migration and indicated that PKA and actin play important roles as downstream effectors.

  6. Loss of MRP4 is associated with impaired platelet activation and cAMP homeostasis

  7. Upregulation of COX-2 in lung cancer promotes overexpression of MRP4 via PGE2-dependent pathway

  8. role of MRP4 in thrombus formation

  9. NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.

  10. Abcc4 in the stomach facilitates the oral absorption of dasatinib, and it possibly plays a similar role for other orally administered substrates, such as acetylsalicylic acid.

ABCC4 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined\; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.

Gene names and symbols associated with ABCC4

  • ATP binding cassette subfamily C member 4 (ABCC4) antibody
  • multidrug resistance-associated protein 4 (LOC515333) antibody
  • multidrug resistance-associated protein 4 (LOC616707) antibody
  • multidrug resistance-associated protein 4 (LOC695407) antibody
  • ATP binding cassette subfamily C member 4 (abcc4) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (Abcc4) antibody
  • ATP binding cassette subfamily C member 4 (Abcc4) antibody
  • D630049P08Rik antibody
  • EST170205 antibody
  • MOAT-B antibody
  • MOATB antibody
  • Mrp4 antibody

Protein level used designations for ABCC4

multidrug resistance-associated protein 4 , ATP-binding cassette, sub-family C (CFTR/MRP), member 4 , ATP-binding cassette protein C4-like , multidrug resistance-associated protein 4-like , ATP-binding cassette sub-family C member 4 , MRP/cMOAT-related ABC transporter , bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4) , canalicular multispecific organic anion transporter (ABC superfamily) , multi-specific organic anion transporter B , multispecific organic anion transporter B , ABC-tranporter , ATP-binding cassette protein C4

GENE ID SPECIES
485523 Canis lupus familiaris
515333 Bos taurus
616707 Bos taurus
695407 Macaca mulatta
100027089 Monodelphis domestica
100050431 Equus caballus
100081616 Ornithorhynchus anatinus
100391624 Callithrix jacchus
100466405 Ailuropoda melanoleuca
100491006 Xenopus (Silurana) tropicalis
10257 Homo sapiens
239273 Mus musculus
170924 Rattus norvegicus
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