anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) Antibodies

The protein encoded by ABCC6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC6 Proteins (15) and ABCC6 Kits (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABCC6 368 O95255
ABCC6 27421 Q9R1S7
ABCC6 81642 O88269
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Top anti-ABCC6 Antibodies at

Showing 10 out of 41 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rat Un-conjugated IHC (fro), IF, WB   1 mL 6 to 8 Days
Human Rat Un-conjugated IHC (fro), FACS, IF, IHC (p), WB   1 mL 6 to 8 Days
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Used in DAB staining on fromalin fixed paraffin- embedded kidney tissue 100 μg 13 to 16 Days
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged ABCC6 is approximately 0.03ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg 11 to 12 Days
Human Rat Un-conjugated ICC, IHC, IHC (fro), WB   1 mL 11 to 14 Days
Human Rat Un-conjugated ICC, IHC, WB   1 mL 11 to 14 Days
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL 11 to 12 Days
Human Mouse Un-conjugated WB Western Blot analysis of ABCC6 expression in transfected 293T cell line by ABCC6 MaxPab polyclonal antibody.Lane 1: ABCC6 transfected lysate(10.89 KDa).Lane 2: Non-transfected lysate. 50 μg 11 to 12 Days
Human Rat Un-conjugated FACS, IHC, IHC (fro), IHC (p), WB   1 mL 11 to 14 Days
Human Rabbit Un-conjugated WB   100 μL 11 to 13 Days

Top referenced anti-ABCC6 Antibodies

  1. Human Monoclonal ABCC6 Primary Antibody for FACS, IHC (fro) - ABIN535128 : Bergen, Plomp, Schuurman, Terry, Breuning, Dauwerse, Swart, Kool, van Soest, Baas, ten Brink, de Jong: Mutations in ABCC6 cause pseudoxanthoma elasticum. in Nature genetics 2000 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal ABCC6 Primary Antibody for ELISA, WB - ABIN559916 : Pinckard, Sheehan, Arthur, Schreiber: Constitutive shedding of both p55 and p75 murine TNF receptors in vivo. in Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)
    Show all 2 Pubmed References

More Antibodies against ABCC6 Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) interaction partners

  1. Six disease causing amino acid mutations in human MRP6 are a normal feature of abcc6 in fish, suggesting they do not have a deleterious effect on the protein.

  2. the L0 cytoplasmic loop of human multidrug resistance protein 6 was characterized.

  3. A novel homozygous frameshift variant in ABCC6(c.1799_1805dupGTCTGGT) was identified in one family and two previously reported missense variants (c.2294G > A and c.2974G > A) in compound heterozygous form in the other family.

  4. Study shows that ABCC6 loss of function in pseudoxanthoma elasticum PXE has a profound impact on vascular purine metabolism through modified arterial gene expression, soluble nucleotidase activities, and, finally, circulating nucleotide levels.

  5. This study identified heterozygous ABCC6 variants as a risk factor for ischemic stroke.

  6. Pilot study examined 3 candidate genes, ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1), ATP Binding Cassette Subfamily C Member 6 (ABCC6), and 5'-Nucleotidase Ecto (NT5E) involved in pyrophosphate (PPi) and inorganic phosphate (Pi) metabolism, which may predispose to coronary arterial or valvular calcification; report 4 new genetic variants potentially related to coronary calcification.

  7. The novel ABCC6 splicing mutation c.1177-2A>G results in multiple splicing patterns. Endogenous U2 to U12 conversion may occur in humans in a disease state. Peripheral blood mononuclear cells can be reliably used to study ABCC6 RNA.

  8. Serum levels of MRP8/MRP14 and MRP6 were up-regulated in patients with Graves' disease (GD) and Hashimoto's thyroiditis (HT). In addition, mRNA expression of MRP proteins in PBMCs and the thyroid gland was markedly elevated in these patients.

  9. High URG7 reduces the ER stress by decreasing the amount of unfolded proteins, by increasing both the total protein ubiquitination and the AKT activation and reducing Caspase 3 activation.

  10. Two compound heterozygous ABCC6 loss-of-function mutations, c.4182_4182delG (p.Lys1394Asnfs*9) and c.2900G > A (p.Trp967*), were found

  11. Genetic analysis revealed three nonsense, four frame-shift, one exon deletion and 13 missense mutations in 73 Japanese pseudoxanthoma elasticum patients.

  12. in a French cohort with pseudoxanthoma elasticum, study identified 538 mutational events with 142 distinct variants, of which 66 were novel

  13. ABCC6 overexpression may also contribute to nilotinib and dasatinib resistance in vitro. With nilotinib and dasatinib now front line therapy options in the treatment of CML, concomitant administration of ABCC6 inhibitors may present an attractive option to enhance TKI efficacy

  14. Using an integrated pathway-based approach, we identified polymorphisms in ABCC6, ABCB1 and CYP2C8 associated with overall survival. These associations were replicated in a large independent cohort, highlighting the importance of pharmacokinetic genes as prognostic markers in Ewing sarcoma

  15. ABCC6 knockdown HepG2 cells show: 1) intracellular reductive stress; 2) cell cycle arrest in G1 phase; 3) upregulation of p21Cip p53 independent; and 4) downregulation of lamin A/C. the absence of ABCC6 profoundly changes the HepG2 phenotype, suggesting that Pseudoxanthoma elasticum syndrome is a complex metabolic disease that is not exclusively related to the absence of pyrophosphate in the bloodstream.

  16. ABCC6 deficiency can be rescued by 4-phenylbutyrate therapy in a mouse model expressing human variants

  17. Biochemical and cell biological analyses demonstrate these mutations influence multiple steps in the biosynthetic pathway, minimally altering local domain structure but adversely impacting ABCC6 assembly and trafficking. The differential impacts on local and global protein structure are consistent with hierarchical folding and assembly of ABCC6.

  18. The results suggest that a transmembrane domain is not required for transport function and that a cytosolic loop maintains ABCC6 in a targeting-competent state for the basolateral membrane and might be involved in regulating the nucleotide binding domains.

  19. The results of this study showed that mtDNA(atp6) variants were actively involved in schizophrenia in some families with maternal inheritance of this

  20. Pseudoxanthoma elasticum is due to mutation of the ABCC6 gene on chromosome 16.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) interaction partners

  1. Abcc6 deficiency in mice leads to altered ABC transporter gene expression in metabolically active tissues.

  2. abrogated ABCC6 function does cause alterations in the metabolic profile of the liver in accordance with PXE being a metabolic disease originating from liver disturbance

  3. bisphosphonates may be helpful for prevention of mineral deposits in Pseudoxanthoma elasticum and generalized arterial calcification of infancy caused by mutations in the ABCC6 gene.

  4. In a mouse model of CKD, ABCC6 protein expression was decreased in liver and kidney, however mRNA levels were unchanged.

  5. In the Abcc6(-/-) genotype, dermal fibroblasts actively contribute to changes that promote matrix calcification; these cells can be further modulated with time by the calcified environment, contributing to the age-dependent progression.

  6. This study showed that the expression of ABCC6 in liver is an important determinant of calcification in cardiac tissues in response to injuries

  7. Magnesium oxide reduces carotid intima media thickness in Abcc6-/- mouse model for pseudoxanthoma elasticum.

  8. Studied the role of genetic modulation and the role of diet in nephrocalcinosis using two established mouse models of ectopic mineralization, Abcc6(tm1Jfk) and Enpp1(asj) mice.

  9. Report lower elasticity and increased myogenic tone without major changes in agonist-dependent contraction in aged Abcc6(-/-) mouse model of pseudoxanthoma elasticum.

  10. the development of cardiac hypertrophy in the 24-month-old Abcc6(-/-) mice suggests that old pseudoxanthoma elasticum patients might be prone to developing late cardiopathy.

  11. ABCC6 is in the basolateral membrane, mediating the sinusoidal efflux of a metabolite from the hepatocytes to systemic circulation.

  12. A single-nucleotide polymorphism in the Abcc6 gene associates with connective tissue mineralization in mice similar to targeted models for pseudoxanthoma elasticum.

  13. Our finding that ABCC6 localizes to the mitochondria-associated membrane has implications for its mechanism of action in normal and diseased states.

  14. Abcc6 as a novel modulator of cardiac myocyte survival after cardiac ischemia-reperfusion (I/R) injury.

  15. These results show that VK3GS is not the essential metabolite transported by ABCC6 from the liver and preventing the symptoms of pseudoxanthoma elasticum.

  16. genetic and biochemical characterization; contribution to aortic calcification

  17. Upregulation of Abca4 in the liver is a tissue-specific compensatory consequence of the 'knock-out' of Abcc6 in mice.

  18. The level of Abcc6 synthesis was investigated in the liver and kidneys and the phenotype of a beta-thalassemia mouse model (Hbbth3/+) for a period of 14 months.

  19. Abcc6 and Rag1 have roles in ectopic mineralization in a murine model of pseudoxanthoma elasticum

  20. the presence of Abcc6 in elastic tissues is not required for elastic fiber assembly

ABCC6 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with ABCC6

  • ATP binding cassette subfamily C member 6 (ABCC6) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (Abcc6) antibody
  • ATP binding cassette subfamily C member 6 (Abcc6) antibody
  • ABC34 antibody
  • Abcc1b antibody
  • ARA antibody
  • DCC antibody
  • dyscalc antibody
  • Dyscalc1 antibody
  • EST349056 antibody
  • GACI2 antibody
  • MLP1 antibody
  • MOAT-E antibody
  • MOATE antibody
  • Mrp6 antibody
  • PXE antibody
  • PXE1 antibody
  • URG7 antibody

Protein level used designations for ABCC6

ATP-binding cassette sub-family C member 6 , anthracycline resistance-associated protein , multi-specific organic anion transporter E , multidrug resistance-associated protein 6 , ATP-binding cassette, sub-family C, member 6 , multidrug resistance-associated protein-6 , ATP-binding cassette, sub-family C (CFTR/MRP), member 6 , MLP-1 , MRP-like protein 1 , liver multidrug resistance-associated protein 6

368 Homo sapiens
27421 Mus musculus
81642 Rattus norvegicus
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