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The product of ACAT2 is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. Additionally we are shipping ACAT2 Kits (30) and ACAT2 Proteins (15) and many more products for this protein.
Showing 10 out of 106 products:
Human Polyclonal ACAT2 Primary Antibody for ICC, IF - ABIN4277555
Martinez-Outschoorn, Lin, Whitaker-Menezes, Howell, Sotgia, Lisanti: Ketone body utilization drives tumor growth and metastasis. in Cell cycle (Georgetown, Tex.) 2012
Human Polyclonal ACAT2 Primary Antibody for IHC, IHC (p) - ABIN4277554
Go, Srivastava, Hernandez-Ono, Gang, Smith, Booth, Ginsberg, Mani: The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. in Cell metabolism 2014
Lipid-induced stabilization of ACAT2 ameliorates lipotoxicity from excessive cholesterol and fatty acid. Cysteine ubiquitylation of ACAT2 constitutes an important mechanism for sensing lipid-overload-induced ROS and fine-tuning lip (show ROS1 Antibodies)id homeostasis.
data demonstrate that the ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters (CE/SE), and suggest that the excretion of lipoproteins containing the ACAT2-catalyzed CS/SE may avoid cytotoxicity
results demonstrate that the low-level expression of human ACAT2 gene with specific CpG-hypomethylated promoter is regulated by the C/EBP transcription factors in monocytic cells, and imply that the lowly expressed ACAT2 catalyzes the synthesis of certain CE/SE that are assembled into lipoproteins for the secretion
Low ACAT2 expression is associated with clear cell renal cell carcinoma (show MOK Antibodies).
results show that the enzymatic activity of mutant Glu(14)Gly is approximately two times higher than wildtype, and that this increase is primarily due to the increased expression and/or stability of the mutant ACAT2 protein
TG-interacting factor 1 (Tgif1 (show TGIF1 Antibodies)) is an important repressor of SOAT2 (show SOAT2 Antibodies) gene expression.
Results show that DLAT (show DLAT Antibodies) and ACAT2 as upstream acetyltransferases of K76 and K294 in 6PGD (show PGD Antibodies) protein.
CDX2 (show CDX2 Antibodies), a known positive regulator of hepatocyte differentiation, was regulated by miR (show MLXIP Antibodies)-181d and directly activated SOAT2 (show SOAT2 Antibodies) gene expression.
Reduced ACAT2 is associated with impaired butyrate oxidation in ulcerative colitis.
HNF4alpha positively regulates ACAT2 gene expression at mRNA level. Overexpression of HNF4alpha increased ACAT2 expression, whereas knockdown of HNF4alpha decreased ACAT2 expression.
lipid-induced stabilization of ACAT2 (show SOAT2 Antibodies) ameliorates lipotoxicity from excessive cholesterol and fatty acid. This unconventional cysteine ubiquitylation of ACAT2 (show SOAT2 Antibodies) constitutes an important mechanism for sensing lipid-overload-induced ROS (show ROS1 Antibodies) and fine-tuning lipid homeostasis.
These studies demonstrate that SOAT2 is a negative regulator of LXR-stimulated fecal neutral sterol loss in mice.
Hepatic knockdown of SOAT2 (show SOAT2 Antibodies) in apoB100 (show APOB Antibodies)-only, LDLr (show LDLR Antibodies)(-/-) mice resulted in remodeling of aortic atherosclerotic lesions into a stable phenotype, suggesting SOAT2 (show SOAT2 Antibodies) is a viable target for the treatment of atherosclerosis.
Intestine-specific MTP (show LAPTM4A Antibodies) and global ACAT2 (show SOAT2 Antibodies) deficiency lowers acute cholesterol absorption with chylomicrons and HDLs (show CSF1R Antibodies)
SOAT2 (show SOAT2 Antibodies) causes hepatic cholesterol to be swiftly mobilized and packaged onto nascent lipoproteins that feed cholesterol into the TICE pathway for fecal excretion.
effect the loss of SOAT2 (show SOAT2 Antibodies) function has on tissue esterified cholesterol sequestration in lysosomal acid lipase (show LIPA Antibodies)-deficient mice in a model of cholesteryl ester storage disease
ACAT2 (show SOAT2 Antibodies) seems to be a hepatic player affecting the cholesterol fluxes fated to VLDL or to HDL (show HSD11B1 Antibodies), the latter via up-regulation of ABCA1 (show ABCA1 Antibodies)
Aortic atherosclerosis development was significantly lower in SOAT2 (show SOAT2 Antibodies) knock-out mice.
ACAT2 increases cholesterol absorption efficiency by providing cholesterol esters for chylomicron transport, but 1 copy of the Acat2 gene, providing approximately 50% of ACAT2 mRNA and enzyme activity, was as effective as 2 copies in promoting cholesterol absorption.
handling of sterols by the intestine involves both G5G8 and ACAT2 but that an additional factor (possibly Niemann-Pick C1-like 1) may be key in determining absorption efficiency
The AACT2-derived acetoacetyl CoA pool generates isoprenoids that are required for normal growth and development. AACT2 is essential and cannot be replaced by AACT1. AACT1 and AACT2 exhibit differential spatial and temporal expression patterns.
ACAT2 might contribute more to metabolic processes than ACAA2 (show ACAA2 Antibodies) in swine.
This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
acetoacetyl Coenzyme A thiolase
, acetyl-CoA acetyltransferase, cytosolic
, acetyl-CoA transferase-like protein
, cytosolic acetoacetyl-CoA thiolase
, acyl Co-A: cholesterol acyltransferase 2
, acyl coenzyme A:cholesterol acyltransferase 2
, acyl-CoA:cholesterol acyltransferase 2
, acyl-coenzyme A:cholesterol acyltransferase 2
, cholesterol acyltransferase 2
, acetyl-Coenzyme A acyltransferase 2
, t-complex protein 1, related sequence 1
, acyl-CoA:cholesterol acyltransferase
, acetyl-Coenzyme A acetyltransferase 2
, acetyl-Coenzyme A acetyltransferase 3
, acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)
, acetyl-CoA acetyltransferase 2
, acetyl-CoA acetyltransferase, cytosolic-like