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The protein encoded by ACSL5 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Additionally we are shipping ACSL5 Proteins (9) and many more products for this protein.
Showing 10 out of 56 products:
Human Monoclonal ACSL5 Primary Antibody for IHC (p), IP - ABIN565656
Mashima, Sato, Sugimoto, Tsuruo, Seimiya: Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions. in Oncogene 2009
Show all 4 Pubmed References
Human Polyclonal ACSL5 Primary Antibody for ELISA, WB - ABIN251402
Obermüller, Keith, Kopitz, Autschbach, Schirmacher, Gassler: Coeliac disease is associated with impaired expression of acyl-CoA-synthetase 5. in International journal of colorectal disease 2006
Human Polyclonal ACSL5 Primary Antibody for IHC, IHC (p) - ABIN4892435
Klett, Chen, Edin, Li, Ilkayeva, Zeldin, Newgard, Coleman: Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. in The Journal of biological chemistry 2013
Human Polyclonal ACSL5 Primary Antibody for WB - ABIN5663854
Yu, Zhang, Cui, Wang, Na, Zhu, Li, Xu, Yang, Christian, Liu: Lipid droplet remodeling and interaction with mitochondria in mouse brown adipose tissue during cold treatment. in Biochimica et biophysica acta 2015
These results suggest that ACSL1 (show Acsl1 Antibodies), ACSL4 (show ACSL4 Antibodies) and ACSL5 expression is regulated by ER signaling pathways and ACSL5 is a potential novel biomarker for predicting prognosis of breast cancer patients.
Functional variant (rs2256368:A>G) affecting ACSL5 exon 20 skipping was identified as a causal factor linked to the migraine-associated rs12355831:A>G, suggesting that the activation of long-chain fatty acids by the spliced ACSL5-Delta20 molecules is involved in migraine pathology.
colorectal adenocarcinomas with low (n=41; group 1) or high (n=31; group 2) ACSL5 levels were identified. In a one-year follow-up, tumour recurrence was significantly increased in group 1.
ACSL5 mediates antiproliferative activities via Wnt2B (show WNT2B Antibodies) palmitoylation with diminished Wnt (show WNT2 Antibodies) activity. The molecular pathway is probably relevant for intestinal homeostasis, overwhelmed by other pathways in carcinogenesis.
Uncoupling of ACSL5 and mitochondrial mortalin (show HSPA9 Antibodies) by mutated TP53 (show TP53 Antibodies) could be important in colorectal carcinogenesis.
Down-regulation of ACSL5 is associated with colorectal cancer.
Levels of acyl-coenzyme A (show SOAT2 Antibodies) synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation.
High ACSL5 transcript levels associate with systemic lupus erythematosus and apoptosis in Jurkat T lymphocytes and peripheral blood cells
The data strongly indicate that human but not rat acyl-CoA synthetase 5 is sensitive to triacsin C and does not compensate for other triacsin C-sensitive ACSL isoforms.
Increased ACSL5 is associated with Fatty Liver.
Acsl5 is a major activator of dietary long chain fatty acids , yet in Acsl5 KO mice residual ACS activity is sufficient for maintaining a normal long chain fatty acids absorption.
Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.
acyl-CoA synthetase long-chain family member 5
, long-chain-fatty-acid--CoA ligase 5
, acyl-CoA synthetase 5
, long-chain-fatty-acid--CoA ligase 5-like
, FACL5 for fatty acid coenzyme A ligase 5
, LACS 5
, fatty acid coenzyme A ligase 5
, fatty-acid-Coenzyme A ligase, long-chain 5
, long-chain acyl-CoA synthetase 5
, long-chain fatty acid coenzyme A ligase 5
, fatty acid Coenzyme A ligase, long chain 5