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Alcohol Dehydrogenase 5 (Class III), chi Polypeptide (ADH5) ELISA Kits

ADH5 encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Additionally we are shipping Alcohol Dehydrogenase 5 (Class III), chi Polypeptide Antibodies (116) and Alcohol Dehydrogenase 5 (Class III), chi Polypeptide Proteins (31) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ADH5 128 P11766
Anti-Rat ADH5 ADH5 100145871 P12711
ADH5 11532 P28474
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Top Alcohol Dehydrogenase 5 (Class III), chi Polypeptide ELISA Kits at antibodies-online.com

Showing 3 out of 6 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 6.7 pg/mL 15.625 pg/mL - 1000 pg/mL Typical Standard Curve 96 Tests Log in to see 15 to 17 Days
$908.41
Details
Human < 12.9 pg/mL 31.2 pg/mL - 2000 pg/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Mouse
  96 Tests Log in to see 16 to 21 Days
$1,161.29
Details

More ELISA Kits for Alcohol Dehydrogenase 5 (Class III), chi Polypeptide Interaction Partners

Human Alcohol Dehydrogenase 5 (Class III), chi Polypeptide (ADH5) interaction partners

  1. Data (including data from studies using knockout and transgenic mice) suggest that obesity and diabetes are accompanied by decreases in GSNOR activity in hepatocytes engendering nitrosative stress; obesity promotes S-nitrosylation of lysosomal proteins in liver, thereby impairing lysosomal enzyme activities and compromising autophagy.

  2. GSNOR represents the prototype enzyme to disclose how denitrosylation plays a crucial role in tuning NO-bioactivity and how much it deeply impacts on cell homeostasis and human pathophysiology. (Review)

  3. It was concluded that in HepG2 cells, ADH5 is a source of formate for de novo purine biosynthesis, especially during folate deficiency when folate-dependent formate production is limited.

  4. GSNOR expression has different effect on neuronal viability in dependence on the stimulus applied, and plays opposite roles in SH-SY5Y models of Parkinson's disease and amyotrophic lateral sclerosis

  5. ADH5 counteracts neuronal differentiation of neural stem cells and this effect can be reversed by pharmacological inhibition of ADH5.

  6. common ADH (show AVP ELISA Kits) variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans.

  7. A decrease in ADH (show AVP ELISA Kits) IB, rather than GSNOR, correlates with human lung cancer.

  8. study compared individuals occupationally exposed to formaldehyde and controls to effects of XRCC3 Thr241Met, ADH5 Val309Ile and Asp353Glu polymorphisms; ADH5 polymorphisms did not show significant association with genotoxicity biomarkers

  9. Data suggest that GSNOR deficiency, through dysregulated S-nitrosylation, may promote hepatocellular carcinoma, possibly by inactivating a DNA repair system.

  10. Significant associations were found however, for reactions to alcohol with a SNP in ADH5 (rs6827292, p = .001) and a SNP just upstream of ADH5 (rs6819724, p = .0007) that is in strong LD with rs6827292.

Mouse (Murine) Alcohol Dehydrogenase 5 (Class III), chi Polypeptide (ADH5) interaction partners

  1. Data (including data from studies using knockout and transgenic mice) suggest that obesity and diabetes are accompanied by decreases in GSNOR activity in hepatocytes engendering nitrosative stress; obesity promotes S-nitrosylation of lysosomal proteins in liver, thereby impairing lysosomal enzyme activities and compromising autophagy.

  2. Report inhibition of GSNOR activity by nebivolol leading to accumulation of nitrosothiols in cells, and this is associated with an enhanced vasodilation by S-nitrosoglutathione.

  3. Increased GSNOR expression during aging decreases S-nitrosation of CaMKIIalpha (show CAMK2 ELISA Kits) and reduces CaMKIIalpha (show CAMK2 ELISA Kits) synaptosomal accumulation.

  4. These data indicate a role for GSNOR in the host response to malaria infection and suggest that strategies to disrupt its activity will improve clinical outcomes.

  5. GSNOR may act as a "brake" on skeletal muscle contractile performance under physiological conditions by modulating nitrosylation/denitrosylation balance.

  6. Loss of GSNOR confers enhanced post-MI cardiac regenerative activity, characterized by enhanced turnover of cardiomyocytes and cardiac stem cells.

  7. Results show that ADH5 removes endogenous formaldehyde to prevent DNA adducts, and protects with FANCD2 (show FANCD2 ELISA Kits), hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage.

  8. S-nitrosoglutathione reductase-dependent modification of PPARgamma (show PPARG ELISA Kits) alters the balance between adipocyte and osteoblast differentiation and provides checkpoint regulation of the lineage bifurcation of these 2 lineages.

  9. These findings provide novel insights into the involvement of GSNOR and S-nitrosylation in neuromuscular atrophy and neuropathic pain that are associated with pathological states.

  10. Overexpression of ADH5 reduces both development and adult neuronal differentiation of neurons. This effect depends on the catalytic activity of ADH5 and involves ADH5-mediated denitrosation of histone deacetylase 2 (HDAC2 (show HDAC2 ELISA Kits)).

Alcohol Dehydrogenase 5 (Class III), chi Polypeptide (ADH5) Antigen Profile

Antigen Summary

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene.

Gene names and symbols associated with ADH5

  • alcohol dehydrogenase 5 (class III), chi polypeptide (ADH5) antibody
  • alcohol dehydrogenase 5 (adh5) antibody
  • alcohol dehydrogenase 5 (class III), chi polypeptide (Adh5) antibody
  • alcohol dehydrogenase 5 (class III), chi polypeptide L homeolog (adh5.L) antibody
  • adh-3 antibody
  • Adh-5 antibody
  • ADH1C antibody
  • adh3 antibody
  • ADH4 antibody
  • adh5 antibody
  • adhx antibody
  • FALDH antibody
  • fdh antibody
  • GSH-FDH antibody
  • gsnor antibody
  • wu:fb60b11 antibody

Protein level used designations for ADH5

S-(hydroxymethyl)glutathione dehydrogenase , alcohol dehydrogenase (class III), chi polypeptide , alcohol dehydrogenase class chi chain , alcohol dehydrogenase class-3 , alcohol dehydrogenase class-III , formaldehyde dehydrogenase , glutathione-dependent formaldehyde dehydrogenase , FALDH , FDH , GSH-FDH , alcohol dehydrogenase 1C (class I), gamma polypeptide , class III alcohol dehydrogenase , fb60b11 , ADH-B2 , alcohol dehydrogenase 2 , alcohol dehydrogenase B2 , class III alcohol dehydrogenase, chi subunit , S-nitrosoglutathione reductase , alcohol dehydrogenase 5 (class III), chi polypeptide L homeolog , alcohol dehydrogenase class 3 , alcohol dehydrogenase 4 (class II), pi polypeptide

GENE ID SPECIES
128 Homo sapiens
100009307 Oryctolagus cuniculus
116517 Danio rerio
100145871 Rattus norvegicus
11532 Mus musculus
505515 Bos taurus
100719427 Cavia porcellus
445841 Xenopus laevis
609781 Canis lupus familiaris
422705 Gallus gallus
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