Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) ELISA Kits

This protein belongs to the aldehyde dehydrogenase family of proteins. Additionally we are shipping Aldehyde Dehydrogenase 2 Family (Mitochondrial) Antibodies (179) and Aldehyde Dehydrogenase 2 Family (Mitochondrial) Proteins (19) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ALDH2 217 P05091
ALDH2 29539 P11884
ALDH2 11669 P47738
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Top Aldehyde Dehydrogenase 2 Family (Mitochondrial) ELISA Kits at antibodies-online.com

Showing 9 out of 21 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.124 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests 13 to 16 Days
$736.84
Details
Rat 0.33 ng/mL 0.78 ng/mL - 50 ng/mL 96 Tests 13 to 16 Days
$800.00
Details
Mouse 5.8 pg/mL 23.5-1500 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Chicken 0.188 ng/mL 0.313-20 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Pig 0.188 ng/mL 0.313-20 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Rabbit 75 pg/mL 125-8000 pg/mL   96 Tests 12 to 14 Days
$715.00
Details
Monkey 0.188 ng/mL 0.313-20 ng/mL   96 Tests 12 to 14 Days
$715.00
Details
Sheep 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 to 18 Days
$852.81
Details
Cow
  96 Tests 15 to 18 Days
$1,029.60
Details

Top referenced Aldehyde Dehydrogenase 2 Family (Mitochondrial) ELISA Kits

  1. Human ALDH2 ELISA Kit for Sandwich ELISA - ABIN415136 : Chen, Zhou, Xiao, Huang, Zhang, Gu, Tang: Inhibition of ALDH2 protects PC12 cells against formaldehyde-induced cytotoxicity: involving the protection of hydrogen sulphide. in Clinical and experimental pharmacology & physiology 2017 (PubMed)

More ELISA Kits for Aldehyde Dehydrogenase 2 Family (Mitochondrial) Interaction Partners

Rabbit Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH-2 is involved in the remote ischemic preconditioning pathway.

Human Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. accumulated ACE and increased DNA damage were identified in Aldh2-knockout (KO) mouse lung tissues in vivo. Consistent with this concept, treatment of lung adenocarcinoma cells with ALDH2 agonist Alda-1 suppressed the proliferation, stemness and migration features of lung adenocarcinoma cells. Thus, activating ALDH2, such as via its agonist, may provide a novel strategy for treatment of lung cancer

  2. Findings support medium to large and unique associations of ALDH2, ADH1B, and ADH1C with Alcohol Use Disorder in East Asians.

  3. All 3 traits ( flushing, alcohol drinking, alcoholism) showed genomewide significant association with variants near ALDH2

  4. the genetic variant of the ALDH2 enzyme seems to specifically affect the susceptibility to methanol in acutely exposed humans and potentially plays a role in the outcome of methanol poisoning.

  5. ALDH2*2 genotype is prevalent among East Asians and is a significant risk factor for both coronary spasm and Acute Myocardial Infarction (Review)

  6. ALDH2 mutation combined with heavy alcohol consumption, suggesting a genetic-environmental interaction in carcinogenesis (Review)

  7. These results suggested that ALDH2 Glu504Lys variant could predict a worse prognosis of acute coronary syndrome patients.

  8. Studies indicate that A allele carriers of mitochondrial Aldehyde Dehydrogenase-2 (ALDH2) gene G487A polymorphism may be particularly susceptible to coronary artery disease (CAD) [Meta-analysis].

  9. The ALDH2 gene might influence changes in cytokine levels and cognitive performance in patients with bipolar disorder.

  10. These data shed new light on the association between genetic polymorphisms of ALDH2 and LDH susceptibility in a Chinese Han population.

  11. The combination of ADH1B*1/*1 and ALDH2*1/*2 markedly increased the risk of esophageal distinct iodine-unstained lesions (DIULs) >/=5 mm (39.3 [10.6-146]). Japanese alcohol-dependent women shared several common risk factors for esophageal squamous cell neoplasia with alcohol-dependent men, but with considerably different magnitudes.

  12. Inactive ALDH2 was negatively correlated with alcohol use problems.

  13. ALDH2 rs671 is associated with hypertension and blood cholesterol level in Chinese population.

  14. Lower expression of ALDH2 is associated with cancer.

  15. Acetaldehyde levels and genotype of its metabolizing enzyme, ALDH2, dictate whether acute ethanol/acetaldehyde plays beneficial or detrimental role in ischaemic hearts.

  16. The Rs671 within ALDH2 but not rs1229984 within ADH1B was associated with lower HDL-C levels in Japanese males.

  17. Patients with ALDH2 504lys variant were less associated with alcoholic liver disease compared to those with ALDH2 504glu using both genotypic and allelic analyses.

  18. Our study suggested that ALDH2 rs671 L-genotypes are protective factors for hypertension in Han Chinese. Consumption of fried food accelerated the development of hypertension in individuals with poor metabolism of acetaldehyde.

  19. ALDH2 genotype is associated with the tolerability and side affects to alcohol in paclitaxel in Japanese breast cancer patients.

  20. The ALDH-2 rs671 polymorphism is a protective factor for essential hypertension susceptibility in man and individuals independently of alcohol consumption in Asians.

Cow (Bovine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH2-catalyzed NO formation is necessary and sufficient for nitroglycerin bioactivation in vascular smooth muscle cells.

  2. ACADM and ALDH2 were predicted to be the target genes of miR-224

  3. analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 and ALDH2

Mouse (Murine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. accumulated ACE and increased DNA damage were identified in Aldh2-knockout (KO) mouse lung tissues in vivo. Consistent with this concept, treatment of lung adenocarcinoma cells with ALDH2 agonist Alda-1 suppressed the proliferation, stemness and migration features of lung adenocarcinoma cells. Thus, activating ALDH2, such as via its agonist, may provide a novel strategy for treatment of lung cancer

  2. studies reveal a novel role of ALDH2 and LDLR in atherosclerosis and provide a molecular mechanism by which ALDH2 rs671 SNP increases CVD.

  3. ALDH2 might be a promising prevention and treatment target for Cyclophosphamide-induced acute cardiotoxicity.

  4. Studied protective role of aldehyde dehydrogenase 2 (ALDH2) in association with signal pathways in high fat diet induced obesity and cardiomyopathy.

  5. esults suggested that ALDH2 may rescue against doxorubicin cardiac toxicity possibly through a TRPV1-mediated protection of mitochondrial integrity.

  6. These results suggested that decrease and deficiency of ALDH2 activity would significantly increase the sensitivity to ETBE-induced genotoxicity as well as hepatotoxic effects after exposure even to low concentrations of ethyl tertiary butyl ether .

  7. ALDH2 deficiency attenuates compensatory cardiac hypertrophy through regulating Akt but not PI3K phosphorylation early after transverse aorta constriction. In vitro, phosphorylation of Akt was significantly accentuated and PTEN expression was reduced while PI3K phosphorylation remained unchanged in stretched cardiomyocytes pretreated by Alda-1 (a small-molecule activator of ALDH2).

  8. data revealed that ALDH2 enzyme may suppress myocardial autophagy possibly through a complex JNK-Bcl-2 and IKKbeta-AMPK-dependent mechanism en route to accentuation of myocardial remodeling and contractile dysfunction in aging.

  9. results thus suggest that ALDH2 is indispensable for the favorable cardiac effect of low-to-moderate alcohol consumption and ALDH2 deficiency may lead to unexpected cardiac dysfunctions via enhancing myocardial apoptosis and necroptosis.

  10. ALDH2 activation improved ethanol-induced cardiac damage and decreased angiotensin and angiotensin II in hearts.

  11. ALDH2 overexpression inhibited the expression of c-Jun N-terminal kinase (JNK)-1, activated protein 1 (AP-1), insulin receptor substrate 1 (IRS-1), 4- hydroxynonenal, caspase 3, transforming growth factor beta1, and collagen I and III, and enhanced Akt phosphorylation.

  12. Study found ALDH2*2 diabetic mice exhibit diastolic dysfunction and preserved systolic function at rest, similar to clinical heart failure of preserved ejection fraction.

  13. ALDH2 deficiency reduced the therapeutic effect of ALDHbr cells in the mice model of ischemic hind limb due to decreased anaerobic glycolysis and increased mitochondrial ROS generation.

  14. osteoblast differentiation is impaired in the absence of Aldh2 gene.

  15. ALDH2 plays a protective role in cyclophosphamide-induced acute hepatotoxicity via attenuating oxidative stress and detoxifying reactive aldehydes.

  16. Deficiency in ALDH2 activity may contribute to increased cisplatin sensitivity and cytotoxicity by producing more ROS by the treatment.

  17. our data suggest that ALDH2 serves as an indispensable cardioprotective factor against insulin resistance-induced cardiomyopathy with a mechanism possibly associated with facilitation of the Sirt3-dependent PGC-1alpha deacetylation.

  18. Findings suggested that ALDH2 can influence atherosclerotic plaque development and vulnerability, and inflammation via MAPK, NF-kappaB and AP-1 signaling pathways.

  19. ALDH2 deficiency triggers decompensation of metabolic reserves and energy metabolism disturbances in early diabetic hearts.

  20. Results show that ALDH2 is required for a normal adipogenesis and its expression in white adipose tissue is negatively correlated with obesity. Also, the study provides evidence that PKCepsilon-ALDH2 pathway positively regulates adipocyte differentiation by regulation of PPARgamma transcriptional activity.

Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Antigen Profile

Antigen Summary

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with ALDH2

  • aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 (aldh2.1) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) L homeolog (aldh2.L) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) (aldh2) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2) antibody
  • aldehyde dehydrogenase 2 (aldh2) antibody
  • aldehyde dehydrogenase (RHA1_RS43090) antibody
  • aldehyde dehydrogenase (NAD(+)) (aldH2) antibody
  • hypothetical protein (OE_RS03015) antibody
  • aldehyde dehydrogenase (aldH2) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) (Aldh2) antibody
  • aldehyde dehydrogenase 2, mitochondrial (Aldh2) antibody
  • Ahd-5 antibody
  • Ahd5 antibody
  • ALDH-E2 antibody
  • aldh2 antibody
  • aldh2a antibody
  • ALDHI antibody
  • ALDM antibody
  • MGC80785 antibody
  • rf2b antibody
  • zgc:63786 antibody

Protein level used designations for ALDH2

aldehyde dehydrogenase 2 , aldehyde dehydrogenase 2 family (mitochondrial) , aldehyde dehydrogenase 2 family (mitochondrial)a , aldehyde dehydrogenase 2.1 , mitochondrial aldehyde dehydrogenase 2 , ALDH2B6 , mitochondrial aldehyde dehydrogenase RF2B , aldehyde dehydrogenase , aldehyde dehydrogenase (NAD(+)) , ALDH class 2 , ALDH-E2 , aldehyde dehydrogenase, mitochondrial , aldehyde dehydrogenase, mitochondrial-like , acetaldehyde dehydrogenase 2 , liver mitochondrial ALDH , nucleus-encoded mitochondrial aldehyde dehydrogenase 2 , ALDH1 , aldehyde dehydrogenase 2, mitochondrial , mitochondrial aldehyde dehydrogenase , ALDHI , AHD-M1

GENE ID SPECIES
393462 Danio rerio
446857 Xenopus laevis
448267 Xenopus (Silurana) tropicalis
452252 Pan troglodytes
542567 Zea mays
713451 Macaca mulatta
4226489 Rhodococcus jostii RHA1
5776113 Staphylococcus aureus subsp. aureus USA300_TCH1516
5952690 Halobacterium salinarum R1
9005267 Rhodobacter capsulatus SB 1003
100171596 Pongo abelii
100217978 Taeniopygia guttata
100338523 Oryctolagus cuniculus
100388478 Callithrix jacchus
217 Homo sapiens
29539 Rattus norvegicus
610941 Canis lupus familiaris
733685 Sus scrofa
508629 Bos taurus
416880 Gallus gallus
11669 Mus musculus
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