Aldehyde Dehydrogenase 2 Family (Mitochondrial) Proteins (ALDH2)

This protein belongs to the aldehyde dehydrogenase family of proteins. Additionally we are shipping Aldehyde Dehydrogenase 2 Family (Mitochondrial) Antibodies (200) and Aldehyde Dehydrogenase 2 Family (Mitochondrial) Kits (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALDH2 217 P05091
ALDH2 29539 P11884
ALDH2 11669 P47738
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Top Aldehyde Dehydrogenase 2 Family (Mitochondrial) Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$295.00
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 13 to 16 Days
$492.31
Details
Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 11 to 12 Days
$282.13
Details
Yeast Leishmania tarentolae His tag   1 mg Log in to see 60 to 71 Days
$3,384.33
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,415.50
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,417.33
Details

ALDH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus) ,

Mouse (Murine) ,

More Proteins for Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Interaction Partners

Rabbit Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH-2 is involved in the remote ischemic preconditioning pathway.

Human Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. Here the authors demonstrate that a missense single nucleotide polymorphism in the ALDH2 gene, rs671 (ALDH2*2), is significantly associated with hip fracture (odds ratio = 2.48, 95% confidence interval: 1.20-5.10, p = 0.021). The rs671 single nucleotide polymorphism was also significantly associated with osteoporosis development (odds ratio = 2.04, 95% confidence interval: 1.07-3.88, p = 0.040).

  2. the mediation effects of single nucleotide polymorphisms (SNPs) in the ADH1B (show ADH1B Proteins) and ALDH2 genes on hepatocellular carcinoma, were investigated.

  3. Three novel SNPs of ALDH2 gene were suggestively significantly associated with serum folate levels.

  4. Coronary Artery Disease patients with mutated ALDH2 genotype are inclined to suffer with coronary artery lesions than wild type subjects.

  5. he ALDH2 Glu504Lys polymorphism may be associated with susceptibility to colorectal cancer (meta-analysis).

  6. rs17033 of ADH1B (show ADH1B Proteins) and rs671 of ALDH2 SNPs were associated with GC risk and smoking habit may further modify the effect of rs671. Conversely, rs4147536 of ADH1B (show ADH1B Proteins) might have a protective role in our study population.

  7. Many studies have shown that ALDH2 polymorphism is a genetic instrument for alcohol use in Mendelian randomization analysis. [review]

  8. Divers studies provide evidence that ALDH2*2 mutant allele (deficiency genotype) is present in nearly half of the East Asian population with ischemic reperfusion injury. [review]

  9. Ethnicity and ALDH2*2 altered the relationship of age of drinking initiation as a risk factor for alcohol use disorder symptoms.

  10. Studied the association between aldehyde dehydrogenase 2(ALDH2) polymorphisms, and risk and prognosis of individuals developing esophageal cancer in Xinjiang Kazak and Han populations.

Cow (Bovine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH2-catalyzed NO formation is necessary and sufficient for nitroglycerin bioactivation in vascular smooth muscle cells.

  2. ACADM (show ACADM Proteins) and ALDH2 were predicted to be the target genes of miR (show MYLIP Proteins)-224

  3. analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 (show ALDH1A1 Proteins) and ALDH2

Mouse (Murine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. Study found ALDH2*2 diabetic mice exhibit diastolic dysfunction and preserved systolic function at rest, similar to clinical heart failure of preserved ejection fraction.

  2. ALDH2 deficiency reduced the therapeutic effect of ALDHbr cells in the mice model of ischemic hind limb due to decreased anaerobic glycolysis and increased mitochondrial ROS (show ROS1 Proteins) generation.

  3. osteoblast differentiation is impaired in the absence of Aldh2 gene.

  4. ALDH2 plays a protective role in cyclophosphamide-induced acute hepatotoxicity via attenuating oxidative stress and detoxifying reactive aldehydes.

  5. Deficiency in ALDH2 activity may contribute to increased cisplatin sensitivity and cytotoxicity by producing more ROS (show ROS1 Proteins) by the treatment.

  6. our data suggest that ALDH2 serves as an indispensable cardioprotective factor against insulin resistance-induced cardiomyopathy with a mechanism possibly associated with facilitation of the Sirt3-dependent PGC-1alpha deacetylation.

  7. Findings suggested that ALDH2 can influence atherosclerotic plaque development and vulnerability, and inflammation via MAPK (show MAPK1 Proteins), NF-kappaB (show NFKB1 Proteins) and AP-1 (show JUN Proteins) signaling pathways.

  8. ALDH2 deficiency triggers decompensation of metabolic reserves and energy metabolism disturbances in early diabetic hearts.

  9. Results show that ALDH2 is required for a normal adipogenesis and its expression in white adipose tissue is negatively correlated with obesity. Also, the study provides evidence that PKCepsilon (show PRKCE Proteins)-ALDH2 pathway positively regulates adipocyte differentiation by regulation of PPARgamma (show PPARG Proteins) transcriptional activity.

  10. In knock-in mice in which ALDH2 enzymatic activity is maximally reduced, cardio-protection in ischemic-reperfused hearts is lacking.

Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Protein Profile

Protein Summary

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with ALDH2

  • aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 (aldh2.1)
  • aldehyde dehydrogenase 2 family (mitochondrial) L homeolog (aldh2.L)
  • aldehyde dehydrogenase 2 family (mitochondrial) (aldh2)
  • aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2)
  • aldehyde dehydrogenase 2 (aldh2)
  • aldehyde dehydrogenase (RHA1_RS43090)
  • aldehyde dehydrogenase (NAD(+)) (aldH2)
  • hypothetical protein (OE_RS03015)
  • aldehyde dehydrogenase (aldH2)
  • aldehyde dehydrogenase 2 family (mitochondrial) (Aldh2)
  • aldehyde dehydrogenase 2, mitochondrial (Aldh2)
  • Ahd-5 protein
  • Ahd5 protein
  • ALDH-E2 protein
  • aldh2 protein
  • aldh2a protein
  • ALDHI protein
  • ALDM protein
  • MGC80785 protein
  • rf2b protein
  • zgc:63786 protein

Protein level used designations for ALDH2

aldehyde dehydrogenase 2 , aldehyde dehydrogenase 2 family (mitochondrial) , aldehyde dehydrogenase 2 family (mitochondrial)a , aldehyde dehydrogenase 2.1 , mitochondrial aldehyde dehydrogenase 2 , ALDH2B6 , mitochondrial aldehyde dehydrogenase RF2B , aldehyde dehydrogenase , aldehyde dehydrogenase (NAD(+)) , ALDH class 2 , ALDH-E2 , aldehyde dehydrogenase, mitochondrial , aldehyde dehydrogenase, mitochondrial-like , acetaldehyde dehydrogenase 2 , liver mitochondrial ALDH , nucleus-encoded mitochondrial aldehyde dehydrogenase 2 , ALDH1 , aldehyde dehydrogenase 2, mitochondrial , mitochondrial aldehyde dehydrogenase , ALDHI , AHD-M1

GENE ID SPECIES
393462 Danio rerio
446857 Xenopus laevis
448267 Xenopus (Silurana) tropicalis
452252 Pan troglodytes
542567 Zea mays
713451 Macaca mulatta
4226489 Rhodococcus jostii RHA1
5776113 Staphylococcus aureus subsp. aureus USA300_TCH1516
5952690 Halobacterium salinarum R1
9005267 Rhodobacter capsulatus SB 1003
100171596 Pongo abelii
100217978 Taeniopygia guttata
100338523 Oryctolagus cuniculus
100388478 Callithrix jacchus
217 Homo sapiens
29539 Rattus norvegicus
610941 Canis lupus familiaris
733685 Sus scrofa
508629 Bos taurus
416880 Gallus gallus
11669 Mus musculus
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