Aminolevulinate Dehydratase Proteins (ALAD)

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). Additionally we are shipping Aminolevulinate Dehydratase Antibodies (66) and Aminolevulinate Dehydratase Kits (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALAD 210 P13716
ALAD 25374 P06214
ALAD 17025 P10518
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Top Aminolevulinate Dehydratase Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag 50 μg 15 to 19 Days
$553.85
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$340.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Yeast Cow His tag   1 mg 60 to 71 Days
$2,887.50
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$2,889.33
Details
Escherichia coli (E. coli) Human S tag,His tag 100 μg 15 to 18 Days
$640.00
Details
Escherichia coli (E. coli) Rat His tag 100 μg 15 to 18 Days
$720.00
Details

ALAD Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus) ,

Mouse (Murine)

More Proteins for Aminolevulinate Dehydratase (ALAD) Interaction Partners

Human Aminolevulinate Dehydratase (ALAD) interaction partners

  1. Automobile paints workers with ALAD 1-2 genotype showed the positive association of blood lead levels with diastolic blood pressure whereas, a genotypic combination of ALAD 1-2/VDR BB showed the negative association of serum uric acid with BLL.

  2. ALAD genetic polymorphisms contribute to high blood lead levels in occupational exposed workers and may predict risk of lead poisoning.

  3. The delta-aminolevulinate dehydratase activity was significantly lower in pregnant women with gestational diabetes mellitus.

  4. The ALAD gene influences bone density among lead workers.

  5. The frequencies of genotype and allelic variants of ALAD rs1800435 did not differ significantly between patients with essential tremor (ET) and controls, and were not influenced by gender. Subjects carrying the ALAD rs1800435CC genotype (wild-type) and the HMOX2 rs1051308GG genotype or the HMOX2 rs1051308G allele had significantly decreased risk for ET.

  6. ALAD SNP rs818708 is significantly associated with risk of lead poisoning.

  7. Overexpression of delta-aminolevulinate dehydratase (ALAD)suppresses breast cancer cell proliferation and invasion and inhibits the epithelial-mesenchymal transition phenotype.

  8. Delta-aminolevulinate dehydratase activity and oxidative stress markers were significantly lowered in preeclampsia.

  9. Results show statistically significant association between the maternal ALAD G177C polymorphism and placental lead levels.

  10. Maternal ALAD gene polymorphism can affect early neonatal neurobehavioral development by influencing the blood lead level.

  11. Genetic variation of ALAD is associated with blood lead level.

  12. This study investigated the delta-aminolevulinate dehydratase (delta-ALA-D) activity in whole blood as well as the parameters of oxidative stress, in lung cancer.

  13. Blood lead level affected ALAD but not GPx activities, and these were not modulated by polymorphisms in ALAD and GPx genes.

  14. Study reveals relationship between ALAD genetic polymorphisms and basic lead toxicological parameters in occupationally exposed workers.

  15. This study showed that ALAD2 and hPEPT2*2 may be valuable markers of risk, and indicate novel mechanisms of lead-induced neurotoxicity

  16. The ff carriers in VDR FokI polymorphism were more susceptible to the effect of lead on the balance system, while other VDR or ALAD genotypes did not significantly modify the effect.

  17. The results indicate that the ALAD1-2/2-2 genotype may have a protective effect in terms of urinary aminolevulinic acid for environmentally lead exposed boys.

  18. Report the effect of ALAD polymorphism on hematopoietic, hepatic and renal toxicity from lead in occupational exposure workers.

  19. Genetic variation in ALAD may modify associations between Pb and prostate cancer

  20. The results lend support to the notion that ALAD polymorphism exerts no marked impact on lead body burden.

Mouse (Murine) Aminolevulinate Dehydratase (ALAD) interaction partners

  1. this study demonstrated for the first time the involvement of striatal delta-ALA-D activity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and its correlation with the MPO activity.

  2. Similar to its role at the beta-globin promoter, KLF1 induces factor recruitment and chromatin changes at the Alad1b promoter in a temporally-specific manner

  3. The data supports the hypothesis that ALAD, an important enzyme for heme synthesis, is also important as a proteasome interacting protein.

  4. Delta-ALA-D from D. melanogaster and M.musculus has a different profile of optimum pH and different sensitivity for diphenyl diselenide and lead, two inhibitors.

Aminolevulinate Dehydratase (ALAD) Protein Profile

Protein Summary

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway\; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.

Gene names and symbols associated with ALAD

  • delta-aminolevulinate dehydratase (hemB)
  • aminolevulinate dehydratase (ALAD)
  • delta-aminolevulinic acid dehydratase (PBGS)
  • delta-aminolevulinic acid dehydratase (STY0404)
  • delta-aminolevulinic acid dehydratase (hemB)
  • delta-aminolevulinic acid dehydratase (SAS1597)
  • delta-aminolevulinic acid dehydratase (SACI_RS03725)
  • delta-aminolevulinic acid dehydratase (ALAD)
  • Delta-aminolevulinic acid dehydratase (hemB)
  • delta-aminolevulinic acid dehydratase (PAAG_00299)
  • delta-aminolevulinic acid dehydratase (VDBG_00315)
  • delta-aminolevulinic acid dehydratase (HPPC_00830)
  • delta-aminolevulinic acid dehydratase (MGYG_01952)
  • Delta-aminolevulinic acid dehydratase (hem2)
  • aminolevulinate dehydratase L homeolog (alad.L)
  • aminolevulinate dehydratase (Alad)
  • aminolevulinate dehydratase (alad)
  • aminolevulinate, delta-, dehydratase (Alad)
  • ALAD protein
  • ALADH protein
  • ALADR protein
  • aminolevulinatedelta-dehydratase protein
  • DDBDRAFT_0190269 protein
  • DDBDRAFT_0231415 protein
  • DDB_0190269 protein
  • DDB_0231415 protein
  • Lv protein
  • ncf protein
  • PBGS protein
  • zgc:110219 protein

Protein level used designations for ALAD

porphobilinogen synthase , aminolevulinate, delta-, dehydratase , delta-aminolevulinic acid dehydratase , Delta-aminolevulinic acid dehydratase , aminolevulinate dehydratase , delta-aminolevulinic acid dehydratase-like , ALADH , delta - aminolevulinic acid dehydratase

GENE ID SPECIES
8616919 Dictyostelium discoideum AX4
464675 Pan troglodytes
811963 Plasmodium falciparum 3D7
1246884 Salmonella enterica subsp. enterica serovar Typhi str. CT18
2662431 Bordetella bronchiseptica RB50
2860701 Staphylococcus aureus subsp. aureus MRSA252
2862870 Staphylococcus aureus subsp. aureus MSSA476
3092987 Burkholderia pseudomallei K96243
3233358 Ehrlichia ruminantium str. Welgevonden
3473841 Sulfolobus acidocaldarius DSM 639
4714527 Yersinia enterocolitica subsp. enterocolitica 8081
4913181 Clostridium difficile 630
5185178 Clostridium botulinum A str. ATCC 3502
5727479 Chlamydomonas reinhardtii
5858769 Chlamydia trachomatis 434/Bu
6933521 Burkholderia cenocepacia J2315
6988018 Aliivibrio salmonicida LFI1238
7758502 Laribacter hongkongensis HLHK9
8714875 Citrobacter rodentium ICC168
8865569 Helicobacter mustelae 12198
9100845 Paracoccidioides sp. 'lutzii' Pb01
9528824 Verticillium alfalfae VaMs.102
9747569 Halomonas elongata DSM 2581
9785237 Helicobacter pylori PeCan4
10033227 Arthroderma gypseum CBS 118893
10050382 Helicobacter felis ATCC 49179
100195823 Salmo salar
100393588 Callithrix jacchus
444422 Xenopus laevis
210 Homo sapiens
474808 Canis lupus familiaris
510679 Bos taurus
25374 Rattus norvegicus
550338 Danio rerio
417274 Gallus gallus
17025 Mus musculus
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