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Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Additionally we are shipping Angiomotin Like 2 Antibodies (20) and Angiomotin Like 2 Kits (4) and many more products for this protein.
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these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP and AKT in liver size control and cancer prevention
study reports for the first time that USP9X is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP inhibition
mTORC2-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP signaling.
AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients.
Scaffold proteins angiomotin (Amot) and angiomotin-related AmotL1 and AmotL2 were recently identified as negative regulators of YAP and TAZ by preventing their nuclear translocation.
These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot family members through direct phosphorylation.
These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process.
AMOTL2 interacts with TAZ and modulates transcriptional activity of TAZ.
AMOTL2 is as a novel activator of LATS2.
Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.
Amot, Amotl1, and Amotl2 are differentially expressed in uterine cells during the peri-implantation period.
Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1.
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.
Leman coiled-coil protein
, angiomotin-like protein 2
, angiomotin like 2
, angiomotin-like protein 2-like
, angiomotin like 2b