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ABTB1 encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions.
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Study showed that BPOZ-2 is a human counterpart of yeast Btb3p, which is a putative adaptor for Pcu3p-based ubiquitin ligase; BPOZ-2 bound to E3 ligase CUL3 (show CUL3 Proteins) in vitro and in vivo.
BPOZ-2 promoted eEF1A1 (show EEF1A1 Proteins) ubiquitylation and degradation, suggesting that eEF1A1 (show EEF1A1 Proteins) is a substrate of BPOZ-2.
This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants.
ankyrin repeat and BTB/POZ domain-containing protein 1
, ankyrin repeat and BTB (POZ) domain containing 1
, ankyrin repeat and BTB/POZ domain-containing protein 1-like
, elongation factor 1A-binding protein
, mFLJ00331 protein